Atrapan-LS 25mg/40mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Chest pain, palpitations, or difficulty breathing
- Sudden swelling of face, lips, tongue, or throat
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Uncontrolled muscle movements, tremors, or rigidity
- High fever with muscle rigidity and confusion
If experiencing severe symptoms, call emergency services immediately.
What is atrapan-ls 25mg/40mg tablet used for?
This medicine is a combination of Levosulpiride 25 mg and Pantoprazole 40 mg used to treat acid reflux, heartburn, and functional dyspepsia. It works by reducing stomach acid and improving gastric motility. It is usually taken once daily before breakfast. Do not crush or chew the tablet. Consult your doctor for proper use.
- Generic Name: Levosulpiride + Pantoprazole
- Manufacturer: Ashlife Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 atrapan-ls 25mg/40mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लेवोसल्पिराइड 25 मिलीग्राम और पैंटोप्राजोल 40 मिलीग्राम का संयोजन है। इसका उपयोग एसिड रिफ्लक्स, सीने में जलन, गैस्ट्रिक समस्याओं और अपच के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट की गतिशीलता को बढ़ाती है। इसे सुबह नाश्ते से पहले खाली पेट लेना चाहिए। इस दवा को डॉक्टर की सलाह के बिना बंद न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, दस्त, पेट दर्द, मुंह सूखना, नींद आना और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में मांसपेशियों में अकड़न, कंपन, असामान्य हरकतें, एलर्जी प्रतिक्रिया, और दिल की धड़कन में गड़बड़ी हो सकती है। अगर आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे सुबह नाश्ते से 30-60 मिनट पहले खाली पेट लें। इस दवा के साथ शराब न लें। एंटासिड को इस दवा से 2 घंटे पहले या बाद में लें। अगर आपको किडनी या लीवर की बीमारी, पार्किंसन रोग, या दौरे की समस्या है तो डॉक्टर को बताएं। दवा को बंद करने से पहले डॉक्टर से सलाह लें।
💊 atrapan-ls 25mg/40mg tablet Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD)","description":"This medicine helps reduce acid reflux and heartburn by suppressing gastric acid secretion and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"It relieves symptoms like bloating, early satiety, and upper abdominal pain by enhancing gastrointestinal motility and reducing acid.","evidence":"Well-established"},{"condition":"Gastritis","description":"Pantoprazole reduces stomach acid, allowing inflamed stomach lining to heal, while Levosulpiride helps with associated nausea and delayed emptying.","evidence":"Well-established"},{"condition":"Peptic ulcer disease","description":"Used as part of therapy to promote ulcer healing by acid suppression and improve symptoms.","evidence":"Well-established"},{"condition":"Nausea and vomiting associated with gastrointestinal disorders","description":"Levosulpiride component provides antiemetic effect by blocking dopamine receptors.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed off-label to improve gastric emptying in diabetic patients with gastroparesis.","evidence":"Limited"},{"condition":"Refractory nausea","description":"May be used off-label for nausea not responding to other antiemetics.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD) and functional dyspepsia
Also treats: Gastritis, Peptic ulcer disease, Nausea and vomiting, Diabetic gastroparesis (off-label)
📋 Drug Information
| Generic Name(s) | Levosulpiride + Pantoprazole |
| Brand Name | Aciban L 75 mg/40 mg Capsule |
| Manufacturer | Ashlife Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate unless specified. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. Guidelines for GERD and dyspepsia generally recommend proton pump inhibitors as first-line therapy; prokinetics may be added in selected cases. Consult local guidelines. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for dyspepsia and GERD may recommend PPI therapy; combination with prokinetics is considered in specific situations. Consult a healthcare professional. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Levosulpiride is a substituted benzamide that acts as a selective dopamine D2 receptor antagonist. It blocks dopamine receptors in the chemoreceptor trigger zone and gastrointestinal tract, which enhances gastric motility, accelerates gastric emptying, and exerts antiemetic effects. Pantoprazole is a proton pump inhibitor that irreversibly inhibits the H+/K+-ATPase enzyme in the parietal cells of the stomach. This enzyme is responsible for the final step of gastric acid secretion. By blocking this pump, pantoprazole reduces both basal and stimulated acid secretion, leading to decreased stomach acid and allowing healing of acid-related damage.
Mechanism Steps
💡 How to Take atrapan-ls 25mg/40mg tablet
Strength: Each immediate-release tablet contains Levosulpiride 25 mg and Pantoprazole 40 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily on an empty stomach, preferably 30-60 minutes before breakfast. However, the dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to therapy. Do not self-adjust the dose. Follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of Levosulpiride, especially extrapyramidal symptoms and drowsiness. Dose adjustment may be necessary. Use with caution and monitor closely. Pantoprazole is generally safe but long-term use may increase risk of fractures and nutrient deficiencies. Consult a doctor for appropriate dosing. |
| Renal Impairment | Levosulpiride is primarily excreted by the kidneys. In patients with renal impairment, dose reduction may be required. For creatinine clearance less than 20 mL/min, Levosulpiride is contraindicated. Pantoprazole does not require dose adjustment in renal impairment. Consult a nephrologist or your doctor for individualized dosing. |
| Hepatic Impairment | Pantoprazole is extensively metabolized in the liver. In patients with severe hepatic impairment, the dose may need to be reduced. Levosulpiride undergoes minimal hepatic metabolism. Use with caution in liver disease. Consult your doctor for appropriate dose adjustment. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (Levosulpiride 25 mg + Pantoprazole 40 mg) per day. Do not exceed this dose unless specifically instructed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of atrapan-ls 25mg/40mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Atazanavir | Major | |
| Ketoconazole | Major | |
| Methotrexate | Major | |
| Levodopa | Major | |
| Clopidogrel | Moderate | |
| Digoxin | Moderate | |
| Fluconazole | Moderate | |
| Antacids | Moderate | |
| SSRIs | Moderate |
🚨 Major Interactions
- Atazanavir, nelfinavir
- Ketoconazole, itraconazole
- Methotrexate
- Warfarin
- Levodopa
⚡ Moderate Interactions
- Clopidogrel
- Digoxin
- Fluconazole
- Antacids
- SSRIs (e.g., fluoxetine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of stomach irritation, worsen acid reflux, and enhance the drowsiness and dizziness caused by Levosulpiride. It may also increase the risk of liver problems. If you consume alcohol, discuss with your doctor about safe limits.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Levosulpiride, Pantoprazole, or any component of the formulation","Parkinson's disease (due to dopamine antagonism by Levosulpiride)","Gastrointestinal bleeding or obstruction","Prolactin-dependent tumors (e.g., pituitary adenoma, breast cancer)","Severe renal impairment (creatinine clearance < 20 mL/min) for Levosulpiride","Concomitant use with levodopa","Pregnancy and breastfeeding unless clearly needed"]
⚠️ Warnings & Precautions
["May cause drowsiness and dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol consumption as it may increase drowsiness and stomach irritation.","Use with caution in elderly patients due to increased risk of extrapyramidal symptoms and falls.","Long-term use of pantoprazole may increase risk of bone fractures, low magnesium, and vitamin B12 deficiency.","May mask symptoms of stomach cancer; rule out malignancy before starting therapy.","Do not use for immediate relief of acute asthma or allergic reactions.","Inform your doctor if you have kidney or liver disease, heart rhythm disorders, or a history of seizures.","Do not stop abruptly without consulting your doctor, especially after prolonged use."]
🤱 Lactation Safety
Not established from the available information. Levosulpiride and Pantoprazole may pass into breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor. Consult your doctor to weigh benefits and risks.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, dizziness, extrapyramidal symptoms, or gastrointestinal upset. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if taken recently. Monitor vital signs and provide supportive care. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with water. It is best taken on an empty stomach, at least 30-60 minutes before breakfast, to maximize the effect of pantoprazole. Avoid alcohol while taking this medicine as it can worsen stomach irritation and increase drowsiness. Do not take antacids within 2 hours of this medicine, as they may reduce its absorption. Inform your doctor if you have kidney or liver disease, Parkinson's disease, or a history of seizures. Do not stop taking this medicine suddenly without consulting your doctor, especially if you have been on it for a long time. Keep out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to side effects such as drowsiness, dizziness, and extrapyramidal symptoms from Levosulpiride. They are also at higher risk of bone fractures and nutrient deficiencies from long-term Pantoprazole use. Dose adjustment and close monitoring are recommended. Falls prevention strategies should be discussed.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both Levosulpiride and Pantoprazole should be used during pregnancy only if clearly needed. Discuss alternative treatments that may be safer during pregnancy and breastfeeding.
🏥 Post-Surgery Considerations
After surgery, inform your surgeon and anesthesiologist about this medicine. It may interact with anesthetic agents or affect gastric motility. Your doctor may advise temporarily stopping it before surgery. Follow your healthcare team's instructions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase the risk of bleeding or interact with medications used during dental work. Your dentist may consult your doctor for guidance.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid vigorous activities immediately after taking the medicine if you experience dizziness or drowsiness. Stay hydrated. If you have heart rhythm concerns, consult your doctor before starting intense exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is best to take it in the morning so that any drowsiness wears off during the day. Inform your employer if your job involves operating heavy machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may advise tapering or stopping. Abrupt discontinuation, especially after long-term use, may cause rebound acid hypersecretion. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine, particularly the Pantoprazole component, may lead to reduced absorption of vitamin B12, magnesium, and calcium, increasing the risk of deficiency and bone fractures. Levosulpiride long-term use may cause tardive dyskinesia or other extrapyramidal symptoms. Regular monitoring of blood levels and clinical assessment is advised. Do not use beyond the prescribed duration without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Avoiding trigger foods, eating smaller meals, and elevating the head of the bed can reduce reflux symptoms.
Evidence: Well-establishedOmeprazole, esomeprazole, or rabeprazole may be used as alternatives based on doctor's advice.
Evidence: Well-establishedRanitidine or famotidine may be used for milder acid suppression.
Evidence: Well-establishedDomperidone or metoclopramide may be used if motility is the primary issue.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medications you are taking. No specific timing adjustments are required.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking it at your usual morning time; if significant time change, consult your doctor for adjustment. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Levosulpiride starts working within 30-60 minutes, while Pantoprazole may take 1-4 days for full acid suppression. Symptom relief may be noticed within a few days.
A: It is best taken on an empty stomach, at least 30-60 minutes before breakfast, to maximize absorption of Pantoprazole.
A: If you remember within a few hours, take it. If it's almost time for the next dose, skip it and continue your regular schedule. Do not double dose.
A: Long-term use may increase risk of bone fractures, low magnesium, and vitamin B12 deficiency. Regular monitoring may be needed. Consult your doctor.
A: No, alcohol should be avoided as it can increase drowsiness, dizziness, and stomach irritation.
A: Seek immediate medical help for uncontrolled muscle movements, severe allergic reactions, black stools, or persistent vomiting.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken anytime, with or without food.
Fact: It should be taken on an empty stomach, at least 30-60 minutes before breakfast, for best effect. - Myth: It is safe to stop this medicine as soon as symptoms improve.
Fact: You should complete the prescribed course and consult your doctor before stopping, as abrupt discontinuation may cause rebound symptoms. - Myth: This medicine is a painkiller for any stomach pain.
Fact: It is specifically for acid-related and motility disorders, not for all types of abdominal pain. - Myth: Taking this medicine with alcohol is fine.
Fact: Alcohol can worsen side effects like drowsiness and stomach irritation, and should be avoided.
🔄 Alternative Options
Generic Alternatives
- Levosulpiride 25 mg + Pantoprazole 40 mg tablet (generic)
Brand Alternatives
- Not applicable. This is a generic name; brand names vary by manufacturer.