Atease ES 0.5 mg/10 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Seizures or convulsions after stopping the medicine suddenly
- Severe allergic reaction with swelling of face, lips, or throat
- Chest pain, palpitations, or fainting
- Confusion, hallucinations, or extreme agitation
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Difficulty breathing or severe drowsiness
- Thoughts of self-harm or suicide
If experiencing severe symptoms, call emergency services immediately.
What is atease es 0.5 mg/10 mg tablet used for?
This medicine is a prescription combination of etizolam 0.5 mg and escitalopram 10 mg used to treat anxiety disorders with depressive symptoms. Etizolam provides rapid anxiety relief, while escitalopram works gradually to improve mood and emotional balance. It should be taken exactly as prescribed and never stopped suddenly.
- Generic Name: Etizolam + Escitalopram Oxalate
- Manufacturer: Aurum Life Science Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 atease es 0.5 mg/10 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एटिजोलम 0.5 मिलीग्राम और एस्सिटालोप्राम 10 मिलीग्राम का संयोजन है। इसका उपयोग चिंता विकार और अवसाद के इलाज के लिए किया जाता है। एटिजोलम तुरंत चिंता और घबराहट को कम करता है, जबकि एस्सिटालोप्राम धीरे-धीरे मूड को बेहतर बनाता है और मानसिक संतुलन लाता है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए और इसे अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, थकान, मुँह सूखना, जी मिचलाना और सिरदर्द शामिल हैं। ये आमतौर पर शुरुआत में होते हैं और धीरे-धीरे कम हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको तेज बुखार, मांसपेशियों में अकड़न, धड़कन तेज होना, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे अपने आप बंद या कम न करें, क्योंकि अचानक बंद करने से दौरे, बेचैनी और अनिद्रा जैसी समस्याएँ हो सकती हैं। दवा लेते समय गाड़ी चलाने या मशीन चलाने से बचें। शराब का सेवन बिल्कुल न करें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। नियमित जांच के लिए डॉक्टर के पास जाते रहें।
💊 atease es 0.5 mg/10 mg tablet Uses & Benefits
[{"condition":"Generalized anxiety disorder with depressive symptoms","description":"This medicine helps reduce excessive worry, restlessness, and low mood when anxiety and depression occur together.","evidence":"Moderate"},{"condition":"Panic disorder with agoraphobia","description":"The etizolam component provides rapid relief of panic attacks while escitalopram addresses underlying anxiety and avoidance behavior.","evidence":"Moderate"},{"condition":"Mixed anxiety and depressive disorder","description":"Used short-term to stabilize mood and reduce anxiety while long-term therapy takes effect.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premenstrual dysphoric disorder","description":"Sometimes prescribed off-label for severe premenstrual mood symptoms, but evidence is limited.","evidence":"Limited"},{"condition":"Insomnia with anxiety","description":"The sedative effect of etizolam may be used off-label for short-term sleep difficulties related to anxiety.","evidence":"Limited"}]
Primary treatment for: Generalized anxiety disorder with depressive symptoms
Also treats: Panic disorder, Mixed anxiety and depressive disorder, Social anxiety disorder
📋 Drug Information
| Generic Name(s) | Etizolam + Escitalopram Oxalate |
| Brand Name | Atease ES |
| Manufacturer | Aurum Life Science Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepine + SSRI |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep in the original container, tightly closed, away from direct sunlight, moisture, and heat. Do not refrigerate unless specified. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture. Do not use after the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Etizolam enhances the inhibitory neurotransmitter GABA at GABA-A receptors, producing rapid anxiolytic, sedative, and muscle-relaxant effects. Escitalopram selectively inhibits the reuptake of serotonin in the brain, increasing serotonin availability and gradually improving mood and anxiety over weeks.
Mechanism Steps
💡 How to Take atease es 0.5 mg/10 mg tablet
Strength: Tablet containing etizolam 0.5 mg and escitalopram oxalate 10 mg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once daily, preferably at the same time each day. The dose may be adjusted by your doctor based on your response and tolerability. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the sedative effects of etizolam and may require a lower starting dose. Escitalopram clearance may be reduced. Start with the lowest effective dose and monitor closely for falls, confusion, and excessive sedation. |
| Renal Impairment | No specific dose adjustment is established for mild to moderate renal impairment. In severe renal impairment, use with caution and monitor closely. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In mild to moderate hepatic impairment, a lower starting dose is recommended. This medicine is contraindicated in severe hepatic impairment. Regular monitoring of liver function is advised. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (etizolam 0.5 mg + escitalopram 10 mg). Do not exceed this dose without medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of atease es 0.5 mg/10 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Warfarin | Major | |
| Opioids | Major | |
| Ketoconazole | Moderate | |
| Omeprazole | Moderate | |
| Ibuprofen | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (opioids, alcohol, barbiturates)
- Warfarin
⚡ Moderate Interactions
- CYP3A4 inhibitors (ketoconazole, clarithromycin)
- CYP2C19 inhibitors (omeprazole, fluoxetine)
- NSAIDs (ibuprofen, naproxen)
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. It enhances the sedative effects of etizolam and can lead to dangerous respiratory depression, severe drowsiness, and impaired coordination. Alcohol may also worsen depression and anxiety, counteracting the therapeutic benefits of escitalopram.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to etizolam, escitalopram, or any component of this medicine","Concurrent use with MAO inhibitors or within 14 days of stopping an MAOI","Severe hepatic impairment","Narrow-angle glaucoma","Myasthenia gravis","Severe respiratory insufficiency","Pregnancy and breastfeeding unless specifically advised by a specialist"]
⚠️ Warnings & Precautions
["This medicine can cause dependence and withdrawal symptoms. Do not stop abruptly.","Avoid driving or operating machinery until you know how this medicine affects you.","Do not consume alcohol while taking this medicine.","Inform your doctor if you have a history of substance abuse, liver disease, kidney disease, or heart problems.","Escitalopram may increase the risk of bleeding, especially when taken with NSAIDs or blood thinners.","Children and adolescents may experience increased suicidal thoughts when starting antidepressants. Close monitoring is required.","This medicine may impair judgment and coordination. Use caution with activities requiring alertness."]
🤱 Lactation Safety
Both etizolam and escitalopram are excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless specifically advised by your doctor after weighing the benefits and risks.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, respiratory depression, seizures, and cardiac arrhythmias. If you suspect an overdose, seek emergency medical care immediately. Treatment is supportive and may include activated charcoal, airway management, and monitoring of vital signs. There is no specific antidote for etizolam, but flumazenil may be used cautiously in benzodiazepine overdose. Escitalopram overdose may require ECG monitoring and management of serotonin syndrome.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you miss multiple doses, contact your doctor for guidance.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not increase, decrease, or stop the dose on your own, because abrupt withdrawal of etizolam can cause seizures, anxiety rebound, or insomnia. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness and slow reaction times. Do not drink alcohol while taking this medicine, as it increases sedation and impairs judgment. Inform your doctor about all other medicines, supplements, and herbal products you use, especially pain relievers, blood thinners, and other antidepressants. Keep all follow-up appointments so your doctor can monitor your response and adjust treatment safely. Store this medicine in its original container, away from children and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative effects of etizolam and may experience increased drowsiness, confusion, and falls. Escitalopram clearance may be reduced. Start with the lowest effective dose and monitor closely. Regular review of the need for continued treatment is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine should be used during pregnancy only if clearly needed. Your doctor may consider switching to a safer alternative or adjusting the dose. Do not stop suddenly without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and increase sedation. Your doctor may advise temporary dose adjustments or monitoring during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may increase drowsiness and interact with sedatives or anesthetics used during dental work. Your dentist may recommend additional precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your balance and coordination. Avoid high-risk activities such as heavy weightlifting, contact sports, or activities requiring sharp focus until you know how the medicine affects you. Light to moderate exercise is generally safe and beneficial.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, dizziness, and impaired concentration, especially during the first few weeks. Avoid driving, operating heavy machinery, or performing tasks that require alertness until you know how it affects you. Inform your employer if your job involves safety-sensitive duties. With time, most people adjust and can resume normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will gradually reduce the dose to prevent withdrawal symptoms and relapse. If you experience severe side effects, contact your doctor immediately for guidance on safe discontinuation.
📅 Long-Term Use Effects
Long-term use of this medicine, particularly the etizolam component, can lead to tolerance, dependence, and withdrawal symptoms. Escitalopram is generally safe for long-term use but requires periodic monitoring of mood, liver function, and electrolytes. Regular follow-up with your doctor is essential to assess the ongoing need for the combination and to taper etizolam when appropriate.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A structured talking therapy that helps change negative thought patterns and behaviors related to anxiety and depression.
Evidence: Well-establishedPractices that reduce stress and improve emotional regulation.
Evidence: ModeratePhysical activity has been shown to reduce symptoms of anxiety and depression.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, consult your doctor about adjusting the timing of your dose. Do not pack it in checked baggage. Check local customs regulations regarding prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Etizolam starts reducing anxiety within 30 to 60 minutes, while escitalopram takes 1 to 2 weeks for initial effects and 4 to 6 weeks for full benefit.
A: No. Stopping suddenly can cause withdrawal symptoms such as seizures, anxiety rebound, and insomnia. Always taper under your doctor's supervision.
A: This medicine can cause drowsiness and slow reaction times. Avoid driving or operating machinery until you know how it affects you.
A: Take it as soon as you remember if it is not close to your next dose. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for atease es 0.5 mg/10 mg tablet
View AllAlternative brands with exact same active ingredient:
-
stayhappi etizolam+escitalopram oxalate 0.5mg/10mg tabletSarvagunaushdhi Pvt Ltd ₹62.50 19.7% CHEAPER
-
etilam fort 0.5mg/10mg tabletLemford Biotech Pvt Ltd ₹65.63 15.7% CHEAPER
-
s vocita e 0.5mg/10mg tabletShine Pharmaceuticals Ltd ₹75.00 3.6% CHEAPER
-
cipam plus tabletTas Med India Pvt Ltd ₹79.69 2.4% COSTLIER
-
etidale plus 0.5mg/10mg tabletAllen Dale Biosciences ₹79.69 2.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is primarily used for anxiety and depression, though it may cause drowsiness as a side effect. - Myth: I can stop this medicine whenever I feel better.
Fact: Stopping suddenly can cause withdrawal symptoms and relapse. Always taper under medical supervision. - Myth: This medicine will make me addicted for life.
Fact: Dependence can occur with long-term etizolam use, but proper tapering and medical supervision minimize this risk.
🔄 Alternative Options
Generic Alternatives
- Etizolam + Escitalopram Oxalate
Brand Alternatives
- Atease ES 0.5 mg/10 mg Tablet