auxen d 500mg/10mg tablet

4.4 (16 reviews)

Naproxen (500mg) Domperidone (10mg)

🏭 Aurum Life Science Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is auxen d 500mg/10mg tablet used for?

Auxen D 500mg/10mg Tablet (Naproxen + Domperidone) is used to treat PAIN ANALGESICS. It contains Naproxen (500mg) + Domperidone (10mg), which Naproxen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Domperidone. Always consult your doctor before use. Take as prescribed.

Generic Name: Naproxen + Domperidone
Manufacturer: Aurum Life Science Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 auxen d 500mg/10mg tablet Uses & Benefits

Pain management with nausea/vomiting, dysmenorrhea, migraine, osteoarthritis, rheumatoid arthritis

Off-label uses: Diabetic gastroparesis, chemotherapy-induced nausea

📋 Drug Information

Generic Name(s)	Naproxen + Domperidone
Brand Name	Auxen D 500mg/10mg Tablet
Manufacturer	Aurum Life Science Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	PAIN ANALGESICS
Action Class	NSAID + Prokinetic agent
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from light and moisture
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionNaproxen: Well absorbed orally; Domperidone: Rapidly absorbed orally

DistributionNaproxen: Widely distributed; Domperidone: Distributed in tissues, low CNS penetration

Protein BindingNaproxen: >99% bound to albumin; Domperidone: 91-93% bound

MetabolismNaproxen: Hepatic via CYP2C9; Domperidone: Hepatic via CYP3A4

Half-LifeNaproxen: 12-17 hours; Domperidone: 7-9 hours

ExcretionNaproxen: Renal (95%); Domperidone: Renal (31%) and fecal (66%)

BioavailabilityNaproxen: ~95%; Domperidone: ~15%

Onset of ActionNaproxen: 1 hour; Domperidone: 30-60 minutes

Peak Plasma TimeNaproxen: 2-4 hours; Domperidone: 1-2 hours

Duration of ActionNaproxen: Up to 12 hours; Domperidone: 4-6 hours

How It Works

Naproxen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Domperidone blocks dopamine D2 receptors in the GI tract, enhancing motility and antiemetic effect

Mechanism Steps

1Naproxen inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis from arachidonic acid.

2Decreased prostaglandins lead to reduced pain, inflammation, and fever.

3Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract.

💡 How to Take auxen d 500mg/10mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of auxen d 500mg/10mg tablet

✅ Common Side Effects

Nausea
Dyspepsia
Abdominal pain
Constipation
Headache
Dizziness
Somnolence

🚨 Serious Side Effects

GI bleeding
Peptic ulcer
Renal failure
Hepatotoxicity
QT prolongation
Torsades de pointes
Anaphylaxis
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Pancreatitis
Agranulocytosis
Aplastic anemia
Gynecomastia
Galactorrhea

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Methotrexate	Major	Increased methotrexate toxicity
Lithium	Major	Increased lithium levels and toxicity
Aspirin	Major	Increased GI ulcer risk
Corticosteroids	Major	Increased GI ulcer risk
SSRIs	Major	Increased bleeding risk
Anticoagulants	Major	Increased bleeding risk
CYP2C9 inhibitors	Major	Increased naproxen levels
CYP3A4 inhibitors	Major	Increased domperidone levels
ACE inhibitors	Moderate	Reduced antihypertensive effect
Diuretics	Moderate	Reduced diuretic effect
Digoxin	Moderate	Increased digoxin levels
Cyclosporine	Moderate	Increased nephrotoxicity
Tacrolimus	Moderate	Increased nephrotoxicity
Antidiabetic agents	Moderate	Enhanced hypoglycemic effect
Phenytoin	Moderate	Increased phenytoin levels
Antacids	Minor	Reduced absorption of naproxen
Cholestyramine	Minor	Reduced absorption of naproxen
Probenecid	Minor	Increased naproxen levels

🚨 Major Interactions

Warfarin
Methotrexate
Lithium
Aspirin
Corticosteroids
SSRIs
Anticoagulants
CYP2C9 inhibitors
CYP3A4 inhibitors

⚡ Moderate Interactions

ACE inhibitors
Diuretics
Digoxin
Cyclosporine
Tacrolimus
Antidiabetic agents
Phenytoin

ℹ️ Minor Interactions

Antacids
Cholestyramine
Probenecid

🍽️ Food Interactions

Naproxen: Food may delay absorption; Domperidone: Food reduces absorption

🍷 Alcohol Interaction

Increased risk of GI bleeding and hepatotoxicity

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, history of GI bleeding, severe renal/hepatic impairment, coronary artery bypass graft surgery, QT prolongation, electrolyte disturbances

📊 Monitoring Parameters

Renal function, hepatic function, blood pressure, signs of GI bleeding, ECG for QT prolongation

🤱 Lactation Safety

Naproxen: Excreted in milk, avoid; Domperidone: Excreted in milk, caution

💊 Overdose Management

Gastric lavage, activated charcoal, supportive care; monitor for GI bleeding, renal function, QT prolongation

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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⭐ User Reviews

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.