auxen d 250mg/10mg tablet
What is auxen d 250mg/10mg tablet used for?
Auxen D 500mg/10mg Tablet (Naproxen + Domperidone) is used to treat PAIN ANALGESICS. It contains Naproxen (250mg) + Domperidone (10mg), which Naproxen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Domperidone. Always consult your doctor before use. Take as prescribed.
- Generic Name: Naproxen + Domperidone
- Manufacturer: Aurum Life Science Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ auxen d 250mg/10mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Naproxen + Domperidone |
| Brand Name | Auxen D 500mg/10mg Tablet |
| Manufacturer | Aurum Life Science Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Prokinetic agent |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Naproxen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Domperidone blocks dopamine D2 receptors in the GI tract, enhancing motility and antiemetic effect
Mechanism Steps
๐ก How to Take auxen d 250mg/10mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of auxen d 250mg/10mg tablet
โ Common Side Effects
- Nausea
- Dyspepsia
- Abdominal pain
- Constipation
- Headache
- Dizziness
- Somnolence
๐จ Serious Side Effects
- GI bleeding
- Peptic ulcer
- Renal failure
- Hepatotoxicity
- QT prolongation
- Torsades de pointes
- Anaphylaxis
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Pancreatitis
- Agranulocytosis
- Aplastic anemia
- Gynecomastia
- Galactorrhea
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels and toxicity |
| Aspirin | Major | Increased GI ulcer risk |
| Corticosteroids | Major | Increased GI ulcer risk |
| SSRIs | Major | Increased bleeding risk |
| Anticoagulants | Major | Increased bleeding risk |
| CYP2C9 inhibitors | Major | Increased naproxen levels |
| CYP3A4 inhibitors | Major | Increased domperidone levels |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Diuretics | Moderate | Reduced diuretic effect |
| Digoxin | Moderate | Increased digoxin levels |
| Cyclosporine | Moderate | Increased nephrotoxicity |
| Tacrolimus | Moderate | Increased nephrotoxicity |
| Antidiabetic agents | Moderate | Enhanced hypoglycemic effect |
| Phenytoin | Moderate | Increased phenytoin levels |
| Antacids | Minor | Reduced absorption of naproxen |
| Cholestyramine | Minor | Reduced absorption of naproxen |
| Probenecid | Minor | Increased naproxen levels |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
- Corticosteroids
- SSRIs
- Anticoagulants
- CYP2C9 inhibitors
- CYP3A4 inhibitors
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Digoxin
- Cyclosporine
- Tacrolimus
- Antidiabetic agents
- Phenytoin
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
- Probenecid
๐ฝ๏ธ Food Interactions
Naproxen: Food may delay absorption; Domperidone: Food reduces absorption
๐ท Alcohol Interaction
Increased risk of GI bleeding and hepatotoxicity
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, history of GI bleeding, severe renal/hepatic impairment, coronary artery bypass graft surgery, QT prolongation, electrolyte disturbances
๐ Monitoring Parameters
Renal function, hepatic function, blood pressure, signs of GI bleeding, ECG for QT prolongation
๐คฑ Lactation Safety
Naproxen: Excreted in milk, avoid; Domperidone: Excreted in milk, caution
๐ Overdose Management
Gastric lavage, activated charcoal, supportive care; monitor for GI bleeding, renal function, QT prolongation
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Found this to be a helpful product. Good results.
Effective and reliable. Worked as expected.
Effective and reliable. Worked as expected.
Good quality medicine. Satisfied with the outcome.
Helpful and effective medicine as per my experience. Always consult a doctor.