asparget 10000iu injection

4.5 (15 reviews)

Asparaginase (10000IU)

🏭 GLS Pharma Ltd. 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is asparget 10000iu injection used for?

Asginase (Asparaginase) is used to treat ANTI NEOPLASTICS. It contains Asparaginase (10000IU), which Depletes extracellular asparagine by catalyzing its conversion to aspartic acid . Always consult your doctor before use. Take as prescribed.

Generic Name: Asparaginase
Manufacturer: GLS Pharma Ltd.
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 asparget 10000iu injection Uses & Benefits

Acute lymphoblastic leukemia (ALL), especially in combination chemotherapy.

Off-label uses: Some lymphomas, acute myeloid leukemia (limited data).

📋 Drug Information

Generic Name(s)	Asparaginase
Brand Name	Asginase
Manufacturer	GLS Pharma Ltd.
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Anticancer-others
Route of Administration	Intravenous or intramuscular injection.
Storage	Store at 2-8°C; do not freeze.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntramuscular or intravenous administration results in rapid absorption.

DistributionDistributes primarily in the intravascular space; limited penetration into cerebrospinal fluid.

Protein BindingMinimal protein binding.

MetabolismMetabolized by the liver via degradation to ammonia and aspartic acid.

Half-Life8-30 hours (varies by formulation and route).

ExcretionExcreted in urine as metabolites.

BioavailabilityNot applicable (parenteral administration).

Onset of ActionRapid (within hours).

Peak Plasma TimeIntravenous: immediately; Intramuscular: 14-24 hours.

Duration of ActionSeveral days to weeks.

How It Works

Depletes extracellular asparagine by catalyzing its conversion to aspartic acid and ammonia, inhibiting protein synthesis in leukemic cells.

Mechanism Steps

1Asparaginase hydrolyzes extracellular asparagine to aspartic acid and ammonia.

2Depletion of asparagine inhibits protein synthesis in leukemic cells.

3Leukemic cells lack asparagine synthetase and are dependent on exogenous asparagine.

💡 How to Take asparget 10000iu injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of asparget 10000iu injection

✅ Common Side Effects

Nausea
Vomiting
Fever
Chills
Anorexia

🚨 Serious Side Effects

Pancreatitis
Thrombosis
Hemorrhage
Hepatotoxicity
Allergic reactions

⚠️ Rare Side Effects

Hyperglycemia
Seizures
Encephalopathy
Renal failure

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Methotrexate	Major	Increased toxicity
Vincristine	Major	Increased neurotoxicity
Prednisone	Major	Increased hyperglycemia
Warfarin	Moderate	Altered anticoagulation
Heparin	Moderate	Increased bleeding risk
Oral contraceptives	Moderate	Reduced efficacy
Allopurinol	Minor	Increased uric acid levels
Loop diuretics	Minor	Electrolyte imbalance

🚨 Major Interactions

Methotrexate
Vincristine
Prednisone

⚡ Moderate Interactions

Warfarin
Heparin
Oral contraceptives

ℹ️ Minor Interactions

Allopurinol
Loop diuretics

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

Avoid alcohol due to increased hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to asparaginase, pancreatitis, history of thrombosis or bleeding disorders.

📊 Monitoring Parameters

Liver function tests, serum amylase, coagulation profile, blood glucose, uric acid.

🤱 Lactation Safety

Not recommended; excreted in breast milk.

💊 Overdose Management

Supportive care; monitor for pancreatitis, coagulopathy, and hepatotoxicity.

⏰ Missed Dose

Administer as soon as possible; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for asparget 10000iu injection

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Alternative brands with exact same active ingredient (Asparaginase (10000IU)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.