Asmabron-N Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Seizures or convulsions
- Severe chest pain or fainting
- Difficulty breathing not relieved by rescue inhaler
- Swelling of face, lips, tongue, or throat
- Yellowing of eyes or skin, or dark urine
- Severe abdominal pain with vomiting
- Irregular or very fast heartbeat
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is asmabron-n tablet used for?
This medicine is a combination of montelukast and theophylline used for long-term control of asthma and related breathing problems. It is not a rescue medicine for sudden attacks. Take it exactly as prescribed, usually once daily, and avoid caffeine and alcohol.
- Generic Name: Montelukast + Theophylline
- Manufacturer: Overseas Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 asmabron-n tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मोंटेलुकास्ट और थियोफिलिन का संयोजन है, जिसका उपयोग अस्थमा और श्वास संबंधी समस्याओं के दीर्घकालिक नियंत्रण के लिए किया जाता है। यह वायुमार्ग की सूजन कम करती है और मांसपेशियों को आराम देकर सांस लेना आसान बनाती है। यह दवा अचानक होने वाले अस्थमा अटैक के लिए नहीं है, इसलिए रेस्क्यू इनहेलर हमेशा साथ रखें। इसे डॉक्टर के बताए अनुसार ही लें और कैफीन तथा शराब से बचें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, जी मिचलाना, पेट में असहजता, बेचैनी और नींद में गड़बड़ी शामिल हैं। कुछ लोगों को धड़कन तेज होना या हल्का कंपन महसूस हो सकता है। गंभीर लक्षण जैसे दौरे पड़ना, सांस लेने में तकलीफ, चक्कर आना, पीलिया या त्वचा पर गंभीर दाने होने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर की सलाह के अनुसार ही लें और खुराक खुद से न बदलें। इसे हर दिन एक ही समय पर पानी के साथ लें। अचानक सांस फूलने पर इसका उपयोग न करें, बल्कि अपना रेस्क्यू इनहेलर इस्तेमाल करें। कैफीन और शराब से बचें क्योंकि इससे धड़कन और बेचैनी बढ़ सकती है। अन्य दवाओं के बारे में डॉक्टर को बताएं और नियमित जांच करवाएं।
💊 asmabron-n tablet Uses & Benefits
[{"condition":"Chronic asthma","description":"Used as add-on controller therapy in adults and adolescents whose asthma is not controlled by inhaled corticosteroids alone.","evidence":"Well-established"},{"condition":"Exercise-induced bronchoconstriction","description":"Helps prevent narrowing of airways triggered by physical activity when taken regularly.","evidence":"Moderate"},{"condition":"Nocturnal asthma symptoms","description":"May reduce night-time wheezing and coughing in some patients when used as part of a controller regimen.","evidence":"Moderate"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Sometimes used as add-on bronchodilator therapy in selected patients with COPD, though not a first-line treatment.","evidence":"Limited"}]
Off-label uses: [{"condition":"Allergic rhinitis with asthma","description":"Montelukast component may help allergic nasal symptoms in patients who also have asthma, but this combination is not specifically approved for isolated allergic rhinitis.","evidence":"Limited"},{"condition":"Sleep-related breathing problems in asthma","description":"Occasionally prescribed off-label to improve night-time breathing in selected asthma patients, but evidence is not strong.","evidence":"Limited"}]
Primary treatment for: Asthma
Also treats: Exercise-induced bronchoconstriction, Nocturnal asthma, COPD (selected patients)
📋 Drug Information
| Generic Name(s) | Montelukast + Theophylline |
| Brand Name | Asmabron-N Tablet |
| Manufacturer | Overseas Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Leukotriene receptor antagonist + Xanthine bronchodilator |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place. Keep the tablets in the original container, away from direct sunlight and moisture. Do not refrigerate unless specifically instructed. |
| Shelf Life | Typically 24 months from the date of manufacture, but always check the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend montelukast as add-on therapy for asthma; theophylline is considered a second-line or add-on bronchodilator in selected patients. |
| ICMR Guideline | Not established from the available information. Consult Indian guidelines for asthma management for specific recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. Montelukast selectively blocks cysteinyl leukotriene receptors in the airways, reducing leukotriene-mediated inflammation, mucus secretion, and bronchoconstriction. Theophylline inhibits phosphodiesterase enzymes, increases cyclic AMP, and blocks adenosine receptors, which relaxes bronchial smooth muscle and improves diaphragm contractility. Together they reduce airway narrowing and inflammation, making breathing easier in asthma and related conditions.
Mechanism Steps
💡 How to Take asmabron-n tablet
Strength: Each tablet contains Montelukast 10 mg and Theophylline 400 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, preferably at the same time each day. The exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, liver function, kidney function, and theophylline blood levels. Do not change the dose without medical advice. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may need a lower dose because theophylline clearance decreases with age and the risk of side effects is higher. Dose must be individualized by a qualified clinician based on liver and kidney function, other medicines, and theophylline blood levels. |
| Renal Impairment | Dose adjustment may be needed in patients with severe kidney impairment because theophylline is partly excreted unchanged by the kidneys. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Dose reduction or avoidance may be necessary in patients with liver disease because theophylline and montelukast are metabolized in the liver. Close monitoring is advised. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on theophylline blood levels and clinical response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of asmabron-n tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Clarithromycin | Major | |
| Fluconazole | Major | |
| Phenytoin | Major | |
| Rifampicin | Major | |
| Propranolol | Moderate | |
| Cimetidine | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Ciprofloxacin
- Clarithromycin
- Fluconazole
- Phenytoin
- Rifampicin
⚡ Moderate Interactions
- Beta-blockers (e.g., propranolol)
- Cimetidine
- Oral contraceptives
- Montelukast with strong CYP3A4 inducers
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the sedative and stimulant effects of theophylline, worsen stomach irritation, and may affect liver metabolism of both ingredients. It can also increase the risk of palpitations, dizziness, and liver strain.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to montelukast, theophylline, or any component of this medicine.","Active peptic ulcer disease or a history of severe gastrointestinal bleeding.","Uncontrolled seizure disorder.","Severe liver disease or cirrhosis.","Use as a rescue medicine for acute asthma attacks.","Children under 15 years of age unless specifically prescribed by a pediatrician."]
⚠️ Warnings & Precautions
["Do not use this medicine to treat sudden asthma attacks; always keep a rescue inhaler available.","Theophylline has a narrow therapeutic index; blood level monitoring may be required.","Avoid caffeine and alcohol while taking this medicine.","Tell your doctor about all other medicines, especially antibiotics and antifungals.","Use with caution in elderly patients and those with heart, liver, or kidney disease.","Report mood changes, sleep problems, or unusual behaviour to your doctor.","Do not stop this medicine suddenly without consulting your doctor."]
🤱 Lactation Safety
Both montelukast and theophylline can pass into breast milk. Theophylline may cause irritability or feeding problems in a breastfed baby. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe nausea, vomiting, restlessness, palpitations, seizures, and irregular heartbeat. If you suspect an overdose, seek emergency medical care immediately. Do not try to induce vomiting unless instructed by a healthcare professional. Treatment is supportive and may include activated charcoal, monitoring of heart rhythm, and management of seizures. Theophylline blood levels may be measured.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for the next dose. If it is more than half the dosing interval, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor and do not change the dose on your own. Swallow the tablet whole with water, preferably at the same time each day. Do not use this medicine as a rescue medicine for sudden asthma attacks; always keep your rescue inhaler with you. Avoid alcohol and reduce caffeine intake because both can increase theophylline side effects. Tell your doctor about all other medicines, especially antibiotics, antifungals, and seizure medicines, as they can interact with this product. Do not start or stop any medicine without informing your doctor. If you miss a dose, follow your doctor's instructions and never double the dose. Keep all follow-up appointments and get blood tests if advised. Seek emergency help for severe breathing difficulty, chest pain, fainting, or seizures.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to theophylline side effects and may need lower doses. Regular monitoring of heart rate, theophylline levels, and kidney function is advised. Falls and dizziness should be monitored.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before continuing this medicine. Theophylline and montelukast should be used during pregnancy only if clearly needed. Your doctor may adjust the dose or switch to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. Theophylline can interact with some anesthetic agents and may affect heart rhythm. Your doctor may advise temporary dose adjustments around surgery.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine. It may cause dry mouth or increase heart rate during dental procedures. Maintain good oral hygiene and inform your dentist about any allergies.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can trigger asthma symptoms. Warm up before exercise and carry your rescue inhaler. If exercise-induced breathing difficulty occurs, stop and use your rescue medicine. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, palpitations, or tremor in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities, but report any unusual symptoms to your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as seizures, severe allergic reactions, or liver problems, seek immediate medical advice. Your doctor may adjust or stop the medicine based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of theophylline blood levels, heart rate, and liver function. Some patients may develop tolerance to theophylline effects. Montelukast has been associated with rare neuropsychiatric effects, so mood and behaviour should be monitored. Regular follow-up helps ensure the dose remains safe and effective.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
First-line controller therapy for persistent asthma.
Evidence: Well-establishedMay be used when theophylline is not tolerated.
Evidence: ModerateCan complement medicine and improve quality of life.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Asthma patients should receive recommended vaccines such as influenza and COVID-19 as advised by their doctor. This medicine does not interact with vaccines, but consult your doctor about timing if you are unwell.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If traveling across time zones, take the dose at the usual time or adjust gradually as advised by your doctor. Store away from direct sunlight and moisture. Check customs rules for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Montelukast may take days to weeks for full effect, while theophylline can start working within 30 minutes to 1 hour. Do not expect immediate relief during an attack.
A: No, this medicine is not a rescue medicine. Use your rescue inhaler for sudden attacks and seek emergency care if breathing does not improve.
A: Avoid caffeine, alcohol, and smoking. Also avoid taking antacids at the same time; separate them by at least 2 hours.
A: Do not stop without consulting your doctor. Stopping suddenly may worsen asthma control.
🤔 Common Patient Concerns
🔄 Substitutes for asmabron-n tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used as a rescue inhaler during an asthma attack.
Fact: This medicine is a controller medicine and does not provide immediate relief. Always use your rescue inhaler for sudden attacks. - Myth: It is safe to take extra doses if breathing is difficult.
Fact: Taking extra doses can cause serious theophylline toxicity. Follow the prescribed dose strictly. - Myth: Coffee helps this medicine work better.
Fact: Caffeine can increase side effects like palpitations and tremor. Limit caffeine intake. - Myth: Once symptoms improve, the medicine can be stopped.
Fact: Do not stop without consulting your doctor; sudden stopping may worsen asthma control.
🔄 Alternative Options
Generic Alternatives
- Montelukast + Theophylline combination (generic)
Brand Alternatives
- Asmabron-N Tablet