asacol 400mg tablet - Mesalazine (400mg) medicine

Asacol 400mg Tablet - Uses, Price, Side Effects

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Mesalazine (400mg)
🏭 Win-Medicare Pvt Ltd 📩 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is asacol 400mg tablet used for?

Asacol 400mg Tablet contains Mesalazine, an anti-inflammatory medicine used to treat ulcerative colitis. It works by reducing inflammation in the colon, helping to control symptoms like diarrhea, abdominal pain, and rectal bleeding. It is typically taken twice daily as directed by a doctor.

  • Generic Name: Mesalazine
  • Manufacturer: Win-Medicare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category B
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 asacol 400mg tablet Uses & Benefits

Treatment of mild to moderate ulcerative colitis, maintenance of remission in ulcerative colitis.

Off-label uses: Crohn's disease, diverticulitis, radiation proctitis.

📋 Drug Information

Generic Name(s)Mesalazine
Brand NameAsacus Sachet
ManufacturerWin-Medicare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class5- Aminosalicylic acid (5-ASA)
Route of AdministrationOral
StorageStore at room temperature (20-25°C) in a dry place, protect from moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMesalazine is released in the colon where it is absorbed. Approximately 20-30% of the dose is absorbed systemically.
DistributionDistributes into tissues, crosses placenta, and enters breast milk in small amounts.
Protein BindingApproximately 40-50% bound to plasma proteins.
MetabolismMetabolized in the intestinal mucosa and liver to N-acetyl-5-aminosalicylic acid (Ac-5-ASA) via N-acetyltransferase.
Half-Life0.5-2 hours for mesalazine; 5-10 hours for its metabolite.
ExcretionPrimarily excreted in urine (as metabolites) and feces (unabsorbed drug).
Bioavailability20-30% after oral administration.
Onset of ActionWithin 3-7 days for symptomatic improvement.
Peak Plasma Time4-6 hours after oral administration.
Duration of ActionUp to 24 hours.

How It Works

Mesalazine inhibits cyclooxygenase and lipoxygenase pathways, reducing prostaglandin and leukotriene synthesis. It also scavenges reactive oxygen species and inhibits nuclear factor-kappa B (NF-ÎșB), leading to decreased inflammatory cytokine production.

Mechanism Steps

1Inhibition of cyclooxygenase (COX) and lipoxygenase pathways
2Reduction of prostaglandin and leukotriene synthesis
3Scavenging of reactive oxygen species
4Inhibition of nuclear factor-kappa B (NF-ÎșB) activation
5Decreased production of pro-inflammatory cytokines (IL-1, IL-6, TNF-α)
6Activation of PPAR-Îł receptors in colonic epithelial cells
7Reduction of mucosal inflammation and tissue damage

💡 How to Take asacol 400mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠ Side Effects of asacol 400mg tablet

✅ Common Side Effects

Nausea
Diarrhea
Headache
Abdominal pain
Flatulence

🚹 Serious Side Effects

Interstitial nephritis
Pancreatitis
Hepatotoxicity
Blood dyscrasias (agranulocytosis, aplastic anemia)
Pericarditis

⚠ Rare Side Effects

Alopecia
Stevens-Johnson syndrome
Lupus-like syndrome
Pulmonary fibrosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Moderate May decrease anticoagulant effect
Azathioprine Moderate Increased risk of myelosuppression
NSAIDs Minor Increased risk of renal toxicity

🚹 Major Interactions

  • Warfarin
  • Azathioprine
  • Mercaptopurine
  • Methotrexate

⚡ Moderate Interactions

  • NSAIDs
  • Corticosteroids
  • Anticoagulants

đŸ· Alcohol Interaction

Alcohol may increase gastrointestinal irritation and worsen side effects.

đŸ›Ąïž Safety & Warnings

đŸš« Contraindications

Hypersensitivity to mesalazine or salicylates, severe renal impairment (eGFR

đŸ€± Lactation Safety

Caution advised; small amounts excreted in breast milk.

💊 Overdose Management

Gastric lavage, activated charcoal, supportive care; monitor renal function.

⏰ Missed Dose

Take as soon as remembered unless close to next dose; skip missed dose if near next dose.

🔄 Substitutes for asacol 400mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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