Artifegnil 60mg Injection - Uses, Price, Side Effects
What is artifegnil 60mg injection used for?
Artifegnil 60mg Injection contains Artesunate, an antimalarial used for severe malaria. It works by killing the malaria parasite in the blood. It is given as an injection under medical supervision for rapid action.
- Generic Name: Artesunate
- Manufacturer: Dr Lee & Morris Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ artifegnil 60mg injection Uses & Benefits
Severe malaria (IV/IM); uncomplicated malaria (oral combination therapy); multidrug-resistant malaria.
Off-label uses: Babesiosis (in combination with other agents); some autoimmune diseases (investigational).
๐ Drug Information
| Generic Name(s) | Artesunate |
| Brand Name | Azunate |
| Manufacturer | Dr Lee & Morris Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial- Artemisinin and derivatives |
| Route of Administration | Intravenous, intramuscular, oral. |
| Storage | Store at room temperature (20-25ยฐC); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Artesunate is a prodrug that is converted to dihydroartemisinin, which generates free radicals that damage parasite proteins and membranes.
Mechanism Steps
๐ก How to Take artifegnil 60mg injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of artifegnil 60mg injection
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Fever
๐จ Serious Side Effects
- Severe allergic reactions
- Hemolytic anemia
- QT prolongation
- Seizures
โ ๏ธ Rare Side Effects
- Neurotoxicity (ataxia, tremors)
- Hepatitis
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Mefloquine | Major | Increased risk of seizures |
| Warfarin | Moderate | Decreased anticoagulant effect |
| Rifampin | Moderate | Reduced artesunate efficacy |
๐จ Major Interactions
- Mefloquine
- Rifampin
- Carbamazepine
- Phenytoin
โก Moderate Interactions
- Warfarin
- Anticoagulants
- Antiplatelet agents
โน๏ธ Minor Interactions
- Grapefruit juice
- Cimetidine
๐ฝ๏ธ Food Interactions
No significant food interactions; absorption may be slightly delayed with high-fat meals.
๐ท Alcohol Interaction
Avoid alcohol; may increase hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to artesunate or any component; first trimester of pregnancy (unless no alternative).
๐ Monitoring Parameters
Parasitemia levels, complete blood count, liver function tests, ECG if co-administered with QT-prolonging drugs.
๐คฑ Lactation Safety
Excreted in breast milk in small amounts; caution advised.
๐ Overdose Management
Supportive care; no specific antidote. Monitor for neurotoxicity (rare).
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
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Medical Note: Always consult your doctor before switching medications.