arotine cr 12.5mg/0.5mg tablet
What is arotine cr 12.5mg/0.5mg tablet used for?
Aroximat Plus 12.5mg/0.5mg Tablet CR (Paroxetine + Clonazepam) is used to treat NEURO CNS. It contains Paroxetine (12.5mg) + Clonazepam (0.5mg), which Paroxetine: Inhibits serotonin reuptake; Clonazepam: Enhances GABA-A receptor ac. Always consult your doctor before use. Take as prescribed.
- Generic Name: Paroxetine + Clonazepam
- Manufacturer: Matias Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ arotine cr 12.5mg/0.5mg tablet Uses & Benefits
Major depressive disorder, panic disorder, generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder
Off-label uses: Premenstrual dysphoric disorder, post-traumatic stress disorder, chronic pain
๐ Drug Information
| Generic Name(s) | Paroxetine + Clonazepam |
| Brand Name | Aroximat Plus 12.5mg/0.5mg Tablet CR |
| Manufacturer | Matias Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Selective Serotonin Reuptake Inhibitor (SSRI) + Benzodiazepine |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Paroxetine: Inhibits serotonin reuptake; Clonazepam: Enhances GABA-A receptor activity
Mechanism Steps
๐ก How to Take arotine cr 12.5mg/0.5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of arotine cr 12.5mg/0.5mg tablet
โ Common Side Effects
- Nausea
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Fatigue
- Weight gain
๐จ Serious Side Effects
- Serotonin syndrome
- Suicidal thoughts
- Seizures
- Severe hypotension
- Respiratory depression
โ ๏ธ Rare Side Effects
- Hyponatremia
- QT prolongation
- Hepatic failure
- Stevens-Johnson syndrome
- Blood dyscrasias
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Serotonin syndrome risk |
| Warfarin | Moderate | Increased bleeding risk |
| Alcohol | Major | Enhanced sedation and CNS depression |
๐จ Major Interactions
- MAOIs
- Linezolid
- Methylene Blue
- CNS Depressants
- CYP2D6 Inhibitors
- CYP3A4 Inhibitors
โก Moderate Interactions
- Anticoagulants
- NSAIDs
- Antiplatelet agents
- Other SSRIs
- Triptans
โน๏ธ Minor Interactions
- Cimetidine
- Omeprazole
- Oral Contraceptives
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice (increases clonazepam levels); take with or without food
๐ท Alcohol Interaction
Avoid alcohol; increased CNS depression
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, concurrent MAOI use, narrow-angle glaucoma, severe respiratory insufficiency, myasthenia gravis
๐ Monitoring Parameters
Liver function, renal function, ECG, suicidal ideation, serotonin syndrome symptoms, sedation level
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk
๐ Overdose Management
Activated charcoal, supportive care, flumazenil for clonazepam (caution in mixed overdose), serotonin syndrome management
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
This medicine was effective for me. I followed the doctor's advice.
Helpful and effective medicine as per my experience. Always consult a doctor.
This medicine was effective for me. I followed the doctor's advice.
This medicine was effective for me. I followed the doctor's advice.
Helpful and effective medicine as per my experience. Always consult a doctor.