Aroximat Plus 12.5mg/0.5mg Tablet CR: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe drowsiness, confusion, or unresponsiveness
- Seizures or convulsions
- Unusual bleeding or bruising
- Yellowing of the skin or eyes
- Chest pain or irregular heartbeat
- Suicidal thoughts or self-harm
If experiencing severe symptoms, call emergency services immediately.
What is arotine cr 12.5mg/0.5mg tablet used for?
This medicine is a controlled-release tablet combining paroxetine (12.5 mg) and clonazepam (0.5 mg). It is used for anxiety disorders. Paroxetine is an SSRI that increases serotonin, while clonazepam is a benzodiazepine that enhances GABA. It is taken once daily, usually at bedtime. Do not stop abruptly.
- Generic Name: Paroxetine + Clonazepam
- Manufacturer: Matias Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 arotine cr 12.5mg/0.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पैरोक्सेटीन और क्लोनाज़ेपम का संयोजन है, जिसका उपयोग चिंता विकार, पैनिक डिसऑर्डर और अवसाद के इलाज के लिए किया जाता है। पैरोक्सेटीन मस्तिष्क में सेरोटोनिन के स्तर को बढ़ाकर मूड को स्थिर करता है, जबकि क्लोनाज़ेपम तुरंत चिंता और घबराहट को कम करता है। यह दवा आमतौर पर रात में सोने से पहले ली जाती है। इसे डॉक्टर के परामर्श के बिना अचानक बंद नहीं करना चाहिए, क्योंकि इससे withdrawal के लक्षण हो सकते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, जी मिचलाना, कब्ज और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, दौरे, या असामान्य रक्तस्राव हो सकते हैं। यदि आपको कोई भी गंभीर लक्षण दिखे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं, पूरा निगल लें। शराब का सेवन बिल्कुल न करें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। दवा अचानक बंद न करें।
💊 arotine cr 12.5mg/0.5mg tablet Uses & Benefits
- [{"condition":"Panic Disorder","description":"This medicine helps reduce the frequency and intensity of panic attacks and anticipatory anxiety.
- The paroxetine component provides long-term control, while clonazepam offers rapid relief during the initial weeks.","evidence":"Well-established"},{"condition":"Generalized Anxiety Disorder","description":"It is used to manage excessive, uncontrollable worry and tension.
- The combination helps stabilize mood and reduce acute anxiety symptoms.","evidence":"Well-established"},{"condition":"Social Anxiety Disorder","description":"This medicine can reduce fear and avoidance in social situations.
- Paroxetine is approved for this condition, and clonazepam may be added short-term for severe anxiety.","evidence":"Moderate"},{"condition":"Major Depressive Disorder with Anxiety","description":"When depression is accompanied by significant anxiety, this combination may be prescribed to address both conditions simultaneously.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Post-Traumatic Stress Disorder","description":"Sometimes prescribed off-label to manage anxiety and sleep disturbances associated with PTSD.","evidence":"Limited"},{"condition":"Obsessive-Compulsive Disorder","description":"Paroxetine is approved for OCD, but the addition of clonazepam is off-label and used only short-term for severe anxiety.","evidence":"Limited"}]
Primary treatment for: Anxiety disorders
Also treats: Panic disorder, Generalized anxiety disorder, Social anxiety disorder, Major depressive disorder with anxiety
📋 Drug Information
| Generic Name(s) | Paroxetine + Clonazepam |
| Brand Name | Aroximat Plus 12.5mg/0.5mg Tablet CR |
| Manufacturer | Matias Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Selective Serotonin Reuptake Inhibitor (SSRI) + Benzodiazepine |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container, tightly closed. Do not store in the bathroom. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Paroxetine selectively inhibits the reuptake of serotonin at the neuronal membrane, thereby increasing serotonin availability in the synaptic cleft. This enhances serotonergic neurotransmission, which over time leads to adaptive changes in mood and anxiety regulation. Clonazepam enhances the inhibitory effect of gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased chloride conductance and hyperpolarization of neurons. This results in rapid calming, muscle relaxation, and anticonvulsant effects. Together, paroxetine provides sustained relief from anxiety and depression, while clonazepam offers immediate symptom control.
Mechanism Steps
💡 How to Take arotine cr 12.5mg/0.5mg tablet
Strength: Controlled-release tablet containing Paroxetine 12.5 mg and Clonazepam 0.5 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to treatment. Typically, treatment is started with a low dose and gradually increased. The usual starting dose is one tablet once daily, preferably at bedtime to minimize daytime drowsiness. The dose may be adjusted based on clinical response and tolerability. Do not exceed the prescribed dose. This medicine is intended for short-term use of the clonazepam component, and the clinician will determine the duration of therapy and tapering schedule. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the sedative and cognitive effects of this medicine. Start with a lower dose and titrate slowly. Monitor closely for falls, confusion, and excessive sedation. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be necessary in patients with renal impairment. Paroxetine and clonazepam are excreted partly by the kidneys. Consult your doctor for appropriate dosing. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Dose reduction is recommended in patients with hepatic impairment. Both paroxetine and clonazepam are metabolized in the liver. Monitor liver function closely. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose of this specific combination is not established from the available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of arotine cr 12.5mg/0.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Thioridazine | Major | |
| Pimozide | Major | |
| Alcohol | Major | |
| Opioids | Major | |
| Warfarin | Moderate | |
| NSAIDs | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| CYP3A4 inhibitors | Moderate | |
| Antihypertensives | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Thioridazine
- Pimozide
- Alcohol
- Opioids
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Warfarin
- CYP2D6 inhibitors (e.g., fluoxetine, quinidine)
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- Antihypertensives
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. The combination can cause severe drowsiness, respiratory depression, impaired judgment, and increased risk of accidents. It can also worsen anxiety and depression in the long run.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to paroxetine, clonazepam, or any component of the formulation","Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI","Concurrent use of thioridazine or pimozide","Narrow-angle glaucoma","Severe respiratory insufficiency","Myasthenia gravis","Severe hepatic impairment","Acute porphyria","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine can cause severe drowsiness. Do not drive or operate machinery until you know how it affects you.","Do not stop this medicine abruptly. Withdrawal symptoms may occur. Taper gradually under medical supervision.","Concomitant use with alcohol or other CNS depressants can cause respiratory depression, coma, or death.","Paroxetine may increase the risk of suicidal thoughts and behaviors, especially in young adults. Monitor closely.","Clonazepam has a high potential for abuse and dependence. Use with caution in patients with a history of substance abuse.","This medicine may impair cognitive and motor function. Avoid activities requiring alertness.","Use with caution in elderly patients due to increased risk of falls, confusion, and sedation.","Inform your doctor if you have a history of seizures, liver disease, kidney disease, or heart disease.","Do not crush, chew, or break the controlled-release tablet. Swallow it whole.","Keep out of reach of children. Store securely to prevent accidental ingestion."]
🤱 Lactation Safety
Both paroxetine and clonazepam are excreted in human breast milk. Paroxetine levels in breast milk are relatively low, but clonazepam can accumulate in the infant and cause sedation, poor feeding, and weight loss. Breastfeeding is not recommended while taking this medicine unless advised by a specialist.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, coma, respiratory depression, seizures, and cardiac arrhythmias. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, gastric lavage, and monitoring of vital signs. Flumazenil, a benzodiazepine antagonist, may be used cautiously for clonazepam toxicity, but it can precipitate seizures in dependent patients. There is no specific antidote for paroxetine. Hemodialysis is not effective for removing paroxetine or clonazepam.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you miss multiple doses, contact your doctor for guidance.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the controlled-release tablet; swallow it whole with a glass of water. Avoid alcohol completely while taking this medicine, as it can intensify drowsiness and impair your ability to drive or operate machinery. Do not drive or engage in hazardous activities until you know how this medicine affects you. Inform your doctor about all other medications you are taking, especially MAO inhibitors, blood thinners, and other sedatives. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not stop this medicine abruptly, as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose. Keep this medicine out of reach of children and store it at room temperature away from moisture and heat. Regular follow-up with your doctor is essential to monitor your response and adjust the dose if needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of sedation, confusion, falls, and cognitive impairment. Start with a lower dose and monitor closely. Avoid concomitant use with other CNS depressants. Regular assessment of renal and hepatic function is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Paroxetine and clonazepam may harm the fetus. Your doctor may switch you to a safer alternative or adjust the dose. Do not stop the medicine abruptly without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It can interact with anesthetic agents and increase the risk of sedation and respiratory depression. Your doctor may advise temporary discontinuation or dose adjustment before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause dry mouth, which may increase the risk of dental problems. Additionally, the sedative effect may interact with dental anesthetics. Your dentist may take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that require balance until you know how this medicine affects you. Drowsiness and dizziness can increase the risk of falls. Light to moderate exercise is generally safe and beneficial for anxiety.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and impaired concentration, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. Avoid these activities until you know how the medicine affects you. Inform your employer if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will gradually reduce the dose to prevent withdrawal symptoms. If you experience severe side effects or allergic reactions, seek immediate medical attention. Long-term use should be reassessed periodically.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and withdrawal symptoms, especially with the clonazepam component. Paroxetine may cause sexual dysfunction, weight changes, and emotional blunting. Regular monitoring of mood, cognitive function, and liver/kidney function is recommended. The clinician will periodically assess the need for continued treatment and may taper the clonazepam after the initial period.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
CBT is highly effective for anxiety disorders and can complement or replace medication in some cases.
Evidence: Well-establishedThese practices can help reduce anxiety and improve emotional regulation.
Evidence: ModeratePhysical activity has been shown to reduce anxiety symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Do not pack it in checked baggage. Carry enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Clonazepam starts working within 30-60 minutes, but paroxetine takes 1-4 weeks for full therapeutic effect.
A: No, abrupt discontinuation can cause withdrawal symptoms. Always taper under medical supervision.
A: Yes, clonazepam has a high potential for dependence. Use only as prescribed and for the shortest duration possible.
A: It is not recommended during pregnancy unless clearly needed. Consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for arotine cr 12.5mg/0.5mg tablet
View AllAlternative brands with exact same active ingredient:
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oxitin plus 12.5mg/0.5mg tablet crPsycormedies ₹84.38 29.7% CHEAPER
-
paroxta plus 12.5 mg/0.5 mg tabletArinna Lifescience Pvt Ltd ₹100.00 16.7% CHEAPER
-
freshika px 12.5mg/0.5mg tabletAmwin Pharmaceuticals ₹103.13 14.1% CHEAPER
-
paro cr plus tabletD D Pharmaceuticals ₹103.13 14.1% CHEAPER
-
patroxta plus 12.5 tablet crArinna Lifescience Pvt Ltd ₹105.00 12.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is primarily used for anxiety disorders. While it can cause drowsiness, it is not a primary sleep aid. - Myth: I can stop this medicine whenever I want.
Fact: Abrupt discontinuation can cause severe withdrawal symptoms. Always taper under medical supervision. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol can dangerously increase sedation and respiratory depression. Avoid completely. - Myth: This medicine works immediately.
Fact: Clonazepam works within hours, but paroxetine takes 1-4 weeks for full effect.
🔄 Alternative Options
Generic Alternatives
- Paroxetine 12.5 mg controlled-release tablet
- Clonazepam 0.5 mg tablet