apriglim-mv 303 tablet sr - Glimepiride (3mg) + Metformin (500mg) medicine

apriglim-mv 303 tablet sr

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🏭 Aprica Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is apriglim-mv 303 tablet sr used for?

This medicine contains Glimepiride (3mg) + Metformin (500mg) and is used to treat ANTI DIABETIC. Glimepiride: Stimulates insulin release from pancreatic beta cells; Metformin: Decreases hepatic glu. Always consult your doctor before use.

  • Generic Name: Glimepiride + Metformin
  • Manufacturer: Aprica Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 apriglim-mv 303 tablet sr Uses & Benefits

Type 2 diabetes mellitus when diet and exercise alone are inadequate

Off-label uses: Polycystic ovary syndrome (metformin component)

📋 Drug Information

Generic Name(s)Glimepiride + Metformin
Brand NameAmaryl M 1mg Tablet PR
ManufacturerAprica Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI DIABETIC
Action ClassSulfonylurea + Biguanide
Route of AdministrationOral
StorageStore at 25°C (77°F); excursions permitted to 15-30°C (59-86°F); protect from moisture
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionGlimepiride: Rapidly and completely absorbed; Metformin: Absorbed mainly from small intestine
DistributionGlimepiride: High protein binding, distributed to breast milk; Metformin: Low protein binding, distributed to erythrocytes
Protein BindingGlimepiride: >99.5%; Metformin: Negligible
MetabolismGlimepiride: Hepatic via CYP2C9; Metformin: Not metabolized
Half-LifeGlimepiride: 5-9 hours; Metformin: 6.2 hours
ExcretionGlimepiride: 60% renal, 40% fecal; Metformin: 90% renal unchanged
BioavailabilityGlimepiride: 100%; Metformin: 50-60%
Onset of ActionGlimepiride: 1 hour; Metformin: 2-3 hours
Peak Plasma TimeGlimepiride: 2-3 hours; Metformin: 2-3 hours
Duration of ActionGlimepiride: 24 hours; Metformin: 8-12 hours

How It Works

Glimepiride: Stimulates insulin release from pancreatic beta cells; Metformin: Decreases hepatic glucose production, increases insulin sensitivity

Mechanism Steps

1Glimepiride binds to SUR1 on pancreatic beta cells
2Closes ATP-sensitive potassium channels
3Depolarizes cell membrane
4Opens voltage-gated calcium channels
5Increases intracellular calcium
6Stimulates insulin exocytosis
7Metformin activates AMPK in liver
8Inhibits gluconeogenesis
9Increases peripheral glucose uptake
10Decreases intestinal glucose absorption

💡 How to Take apriglim-mv 303 tablet sr

Follow your doctor's prescription exactly.

⚠️ Side Effects of apriglim-mv 303 tablet sr

✅ Common Side Effects

Hypoglycemia
Nausea
Diarrhea
Abdominal pain
Headache
Dizziness

🚨 Serious Side Effects

Lactic acidosis
Severe hypoglycemia
Hepatic injury
Pancreatitis

⚠️ Rare Side Effects

Megaloblastic anemia
Photosensitivity
Disulfiram-like reaction
Cholestatic jaundice

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Insulin Major Increased risk of hypoglycemia
Miconazole Major Enhanced hypoglycemic effect
Alcohol Major Increased risk of lactic acidosis and hypoglycemia
ACE inhibitors Moderate Enhanced hypoglycemic effect
Beta-blockers Moderate Mask hypoglycemia symptoms
Corticosteroids Moderate Hyperglycemia
Diuretics Moderate Hyperglycemia
NSAIDs Moderate Enhanced hypoglycemic effect
Cimetidine Minor Increased metformin levels
Nifedipine Minor Increased metformin absorption

🚨 Major Interactions

  • Insulin
  • Other sulfonylureas
  • Miconazole
  • Phenylbutazone
  • Alcohol

⚡ Moderate Interactions

  • ACE inhibitors
  • Beta-blockers
  • Clarithromycin
  • Corticosteroids
  • Diuretics
  • NSAIDs

🍷 Alcohol Interaction

Increased risk of hypoglycemia and lactic acidosis

🛡️ Safety & Warnings

🚫 Contraindications

Type 1 diabetes, diabetic ketoacidosis, severe renal impairment (eGFR

🤱 Lactation Safety

Contraindicated; glimepiride excreted in milk, metformin excreted in milk

💊 Overdose Management

Monitor blood glucose; treat hypoglycemia with oral glucose or IV dextrose; for metformin overdose, consider hemodialysis

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose

🔄 Substitutes for apriglim-mv 303 tablet sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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