apcold tablet - Caffeine (30mg) + Diphenhydramine (25mg) medicine

Apcold Tablet - Uses, Price, Side Effects

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๐Ÿญ Aanika Pharma ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is apcold tablet used for?

Apcold Tablet is a combination medicine used for the symptomatic relief of the common cold and allergies. It contains Caffeine (a stimulant) and Diphenhydramine (an antihistamine). Diphenhydramine blocks histamine to reduce sneezing, runny nose, and watery eyes, while Caffeine counteracts drowsiness caused by the antihistamine, helping you stay alert.

  • Generic Name: Caffeine + Diphenhydramine
  • Manufacturer: Aanika Pharma
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š apcold tablet Uses & Benefits

Symptomatic relief of common cold, allergic rhinitis, sinusitis

Off-label uses: Motion sickness, insomnia (diphenhydramine alone)

๐Ÿ“‹ Drug Information

Generic Name(s)Caffeine + Diphenhydramine
Brand NameAnti Cold Tablet
ManufacturerAanika Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + CNS Stimulant
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally
DistributionDistributes widely; crosses blood-brain barrier
Protein BindingCaffeine: 35-36%; Diphenhydramine: 78-85%
MetabolismCaffeine: Hepatic (CYP1A2); Diphenhydramine: Hepatic (CYP2D6, others)
Half-LifeCaffeine: 3-5 hours; Diphenhydramine: 2.4-9.3 hours
ExcretionRenal (urine)
BioavailabilityCaffeine: ~100%; Diphenhydramine: ~50-70%
Onset of Action30-60 minutes
Peak Plasma TimeCaffeine: 30-60 min; Diphenhydramine: 1-3 hours
Duration of Action4-6 hours

How It Works

Diphenhydramine blocks histamine H1 receptors; Caffeine antagonizes adenosine receptors

Mechanism Steps

1Diphenhydramine binds to H1 receptors, blocking histamine action
2Caffeine blocks adenosine receptors, reducing sedation
3Combination reduces allergy symptoms while counteracting drowsiness

๐Ÿ’ก How to Take apcold tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of apcold tablet

โœ… Common Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Nervousness

๐Ÿšจ Serious Side Effects

  • Seizures
  • Arrhythmias
  • Hallucinations

โš ๏ธ Rare Side Effects

  • Blood dyscrasias
  • Anaphylaxis
  • Liver injury

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Alcohol Moderate Increased drowsiness and dizziness
MAOIs Major Risk of hypertensive crisis
CNS Depressants Moderate Additive sedative effects

๐Ÿšจ Major Interactions

  • MAOIs
  • CNS depressants

โšก Moderate Interactions

  • CYP1A2 inhibitors
  • CYP2D6 inhibitors

โ„น๏ธ Minor Interactions

  • Anticholinergics
  • Other CNS stimulants

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase caffeine levels

๐Ÿท Alcohol Interaction

Increased CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypersensitivity, severe hypertension, narrow-angle glaucoma, MAOI use

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, CNS effects

๐Ÿคฑ Lactation Safety

Not recommended; excreted in breast milk

๐Ÿ’Š Overdose Management

Activated charcoal, supportive care; for severe symptoms: benzodiazepines for seizures

โฐ Missed Dose

Take as soon as remembered; skip if near next dose; do not double

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

๐Ÿ”— View Profile

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