Antrima DS 800mg/160mg Tablet - Uses, Price, Side Effects
What is antrima ds 800mg/160mg tablet used for?
Antrima DS 800mg/160mg Tablet is a combination antibiotic containing Sulfamethoxazole and Trimethoprim. It works by stopping the growth of bacteria and is used to treat various infections such as urinary tract infections, respiratory infections, and ear infections.
- Generic Name: Sulfamethoxazole + Trimethoprim
- Manufacturer: Abbott
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ antrima ds 800mg/160mg tablet Uses & Benefits
Urinary tract infections, Acute otitis media, Pneumocystis jirovecii pneumonia, Traveler's diarrhea, Shigellosis, Bronchitis
Off-label uses: Toxoplasmosis, Nocardiosis, Whipple's disease
๐ Drug Information
| Generic Name(s) | Sulfamethoxazole + Trimethoprim |
| Brand Name | Antrima DS |
| Manufacturer | Abbott |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Sulfonamide + Folate antagonist |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Sequential inhibition of folate synthesis: Sulfamethoxazole inhibits dihydropteroate synthase; Trimethoprim inhibits dihydrofolate reductase
Mechanism Steps
๐ก How to Take antrima ds 800mg/160mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of antrima ds 800mg/160mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Photosensitivity
๐จ Serious Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Aplastic anemia
- Agranulocytosis
- Hepatitis
- Interstitial nephritis
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Pancreatitis
- Serum sickness
- Lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| ACE inhibitors | Moderate | Increased risk of hyperkalemia |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Phenytoin
- Sulfonylureas
- Cyclosporine
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Procainamide
- Amantadine
โน๏ธ Minor Interactions
- Oral contraceptives
- Rifampin
๐ฝ๏ธ Food Interactions
Folate-rich foods may reduce efficacy
๐ท Alcohol Interaction
Avoid alcohol; may cause disulfiram-like reaction
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to sulfonamides or trimethoprim, Severe hepatic or renal impairment, Megaloblastic anemia due to folate deficiency, Pregnancy (especially 1st and 3rd trimester), Infants <2 months
๐ Monitoring Parameters
Renal function, Hepatic function, CBC with differential, Serum potassium, Signs of hypersensitivity
๐คฑ Lactation Safety
Caution; excreted in breast milk; avoid in nursing infants <2 months
๐ Overdose Management
Gastric lavage, activated charcoal, supportive care; folate supplementation for trimethoprim toxicity
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose