Antop-DSR Capsule - Uses, Price, Side Effects, Dosage
What is antop-dsr capsule used for?
Antop-DSR Capsule is a combination medicine containing Domperidone (30mg) and Pantoprazole (40mg) used to treat gastroesophageal reflux disease (GERD), acidity, and heartburn. Domperidone helps in preventing nausea and vomiting by increasing stomach motility, while Pantoprazole reduces stomach acid production by inhibiting the proton pump in the stomach lining. This dual action provides relief from acid reflux and associated symptoms.
- Generic Name: Domperidone + Pantoprazole
- Manufacturer: Rhophic Health Care
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ antop-dsr capsule Uses & Benefits
Gastroesophageal reflux disease (GERD), dyspepsia, gastroparesis, peptic ulcer disease, Zollinger-Ellison syndrome (pantoprazole component).
Off-label uses: Domperidone: Lactation stimulation (not approved in many countries); Pantoprazole: Prevention of stress ulcers, eosinophilic esophagitis.
๐ Drug Information
| Generic Name(s) | Domperidone + Pantoprazole |
| Brand Name | Anleo-DSR Capsule |
| Manufacturer | Rhophic Health Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone is a dopamine D2 receptor antagonist that enhances gastric motility and accelerates gastric emptying. Pantoprazole is a proton pump inhibitor that irreversibly inhibits H+/K+ ATPase in gastric parietal cells, reducing gastric acid secretion.
Mechanism Steps
๐ก How to Take antop-dsr capsule
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of antop-dsr capsule
โ Common Side Effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Flatulence
- Dry mouth
- Dizziness
๐จ Serious Side Effects
- QT prolongation
- Ventricular arrhythmias
- Extrapyramidal symptoms (domperidone)
- Clostridium difficile infection
- Bone fracture (long-term)
- Hypomagnesemia
- Interstitial nephritis
โ ๏ธ Rare Side Effects
- Gynecomastia
- Galactorrhea
- Jaundice
- Hepatitis
- Anaphylaxis
- Stevens-Johnson syndrome
- Agranulocytosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | May increase INR and bleeding risk |
| Ketoconazole | Moderate | Increased risk of QT prolongation |
| Methotrexate | Major | Increased methotrexate toxicity |
๐จ Major Interactions
- Ketoconazole
- Itraconazole
- Voriconazole
- Clarithromycin
- Erythromycin
- Ritonavir
- Saquinavir
- Amiodarone
- Quinidine
- Methotrexate
โก Moderate Interactions
- Warfarin
- Cilostazol
- Citalopram
- Escitalopram
- Fluoxetine
- Paroxetine
- Sertraline
- Tacrolimus
- Cyclosporine
- Digoxin
โน๏ธ Minor Interactions
- Sucralfate
- Antacids
- Iron supplements
- Calcium carbonate
๐ฝ๏ธ Food Interactions
Food delays absorption of domperidone; pantoprazole should be taken before meals for optimal effect.
๐ท Alcohol Interaction
Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component; gastrointestinal hemorrhage, obstruction, or perforation; prolactinoma; concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole) causing QT prolongation; severe hepatic impairment.
๐ Monitoring Parameters
Liver function tests, ECG (QT interval), serum electrolytes, magnesium levels (long-term use), renal function.
๐คฑ Lactation Safety
Domperidone is excreted in breast milk; pantoprazole is excreted in small amounts. Caution advised.
๐ Overdose Management
Supportive care; domperidone overdose may cause extrapyramidal symptoms; pantoprazole overdose unlikely to cause serious effects.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next dose; do not double dose.