antazer rd 30mg/40mg tablet allopathy (Domperidone (30mg) + Rabeprazole (40mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India
antazer rd 30mg/40mg tablet allopathy (Domperidone (30mg) + Rabeprazole (40mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Crassula Pharmaceuticals Pvt Ltd. Contains Domperidone (30mg) + Rabeprazole (40mg).

antazer rd 30mg/40mg tablet - Uses, Price, Side Effects & Substitutes

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🏭 Crassula Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 21, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is antazer rd 30mg/40mg tablet used for?

Acera-D Capsule SR (Domperidone + Rabeprazole) is used to treat Gastroesophageal reflux disease (GERD). It contains Domperidone (30mg) + Rabeprazole (40mg), which Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and . Always consult your doctor before use. Take as prescribed.

  • Generic Name: Domperidone + Rabeprazole
  • Manufacturer: Crassula Pharmaceuticals Pvt Ltd
  • Medicine Form: Allopathy
  • Pregnancy Category: A

🇮🇳 antazer rd 30mg/40mg tablet के बारे में संक्षिप्त जानकारी (Hindi Summary)

antazer rd 30mg/40mg tablet का उपयोग मुख्य रूप से gastro intestinal और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Domperidone (30mg) + Rabeprazole (40mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

📋 Drug Information

Generic Name(s)Domperidone + Rabeprazole
Brand NameAcera-D Capsule SR
ManufacturerCrassula Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProkinetic agent + Proton pump inhibitor
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionDomperidone: Rapidly absorbed after oral administration; Rabeprazole: Well absorbed, peak plasma concentration at 2-4 hours.
DistributionDomperidone: Widely distributed, crosses blood-brain barrier minimally; Rabeprazole: Volume of distribution ~0.3 L/kg.
Protein BindingDomperidone: 91-93%; Rabeprazole: 96%.
MetabolismDomperidone: Hepatic via CYP3A4; Rabeprazole: Hepatic via CYP2C19 and CYP3A4.
Half-LifeDomperidone: 7-9 hours; Rabeprazole: 1-2 hours.
ExcretionDomperidone: Urine (31%) and feces (66%); Rabeprazole: Urine (90%) as metabolites.
BioavailabilityDomperidone: 13-17%; Rabeprazole: 52%.
Onset of ActionDomperidone: 30-60 minutes; Rabeprazole: 1-2 hours.
Peak Plasma TimeDomperidone: 1-2 hours; Rabeprazole: 2-4 hours.
Duration of ActionDomperidone: 4-6 hours; Rabeprazole: Up to 24 hours.

Pharmacodynamics

Mechanism of ActionDomperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Rabeprazole: Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells, reducing gastric acid secretion.
Target ReceptorDomperidone: Dopamine D2 receptor; Rabeprazole: H+/K+ ATPase (proton pump).
Pharmacodynamic EffectsDomperidone: Increases lower esophageal sphincter pressure, enhances gastric peristalsis, and accelerates gastric emptying. Rabeprazole: Suppresses basal and stimulated gastric acid secretion, raising intragastric pH.

💡 How and when to take antazer rd 30mg/40mg tablet?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Store at room temperature (20-25°C), protect from light and moisture.

⚙️ How antazer rd 30mg/40mg tablet Works

Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Rabeprazole: Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells, reducing gastric acid secretion.

1 Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone and GI tract.
⬇️
2 This increases lower esophageal sphincter pressure and enhances gastric motility.
⬇️
3 Rabeprazole accumulates in the acidic environment of gastric parietal cells.
⬇️
4 It binds irreversibly to the H+/K+ ATPase enzyme, inhibiting proton transport.
⬇️
5 This leads to a sustained reduction in gastric acid secretion.

💊 antazer rd 30mg/40mg tablet Uses in Hindi (Ke Fayde), Benefits & Indications

Gastroesophageal reflux disease (GERD), dyspepsia, gastroparesis, nausea and vomiting.

Off-label uses: Diabetic gastroparesis, cyclic vomiting syndrome, migraine-associated nausea.

⚠️ What are the side effects of antazer rd 30mg/40mg tablet?

✅ Common Side Effects

  • Headache
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Nausea
  • Dry mouth

🚨 Serious Side Effects

  • QT prolongation
  • Ventricular arrhythmias
  • Torsades de pointes
  • Gynecomastia
  • Galactorrhea
  • Liver injury

⚠️ Rare Side Effects

  • Extrapyramidal symptoms
  • Hyperprolactinemia
  • Interstitial nephritis
  • Clostridium difficile infection

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug Severity Effect
Ketoconazole Major Increased risk of QT prolongation and arrhythmias
Warfarin Moderate Increased INR and bleeding risk
Digoxin Moderate Increased digoxin levels
Antacids Minor Reduced absorption of rabeprazole

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
  • CYP2C19 inhibitors (e.g., fluconazole)
  • QT-prolonging drugs (e.g., amiodarone, moxifloxacin)

⚡ Moderate Interactions

  • Antacids
  • Sucralfate
  • Digoxin
  • Methotrexate

ℹ️ Minor Interactions

  • Caffeine
  • Theophylline

🍽️ Food Interactions

Food may delay absorption of domperidone; rabeprazole absorption unaffected by food.

🍷 Alcohol Interaction

Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to domperidone or rabeprazole; gastrointestinal hemorrhage, obstruction, or perforation; prolactinoma; concomitant use with QT-prolonging drugs or strong CYP3A4 inhibitors.

📊 Monitoring Parameters

ECG for QT interval; liver function tests; renal function; serum electrolytes.

🤱 Lactation Safety

Domperidone: Excreted in breast milk, may cause adverse effects; Rabeprazole: Excreted in breast milk, use with caution.

💊 Overdose Management

Symptomatic and supportive treatment; gastric lavage; monitoring of ECG for QT prolongation.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

🛑 Myths vs. Facts about antazer rd 30mg/40mg tablet

  • Myth: Generic substitutes of antazer rd 30mg/40mg tablet are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Domperidone (30mg) + Rabeprazole (40mg)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of antazer rd 30mg/40mg tablet can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

💬 Real Patient Experiences (Astitva)

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Read real stories and discussions from our patient community regarding similar health conditions.

Migraine Relief: Triggers, Treatment & Home Remedies

Namaste, and welcome to the Astitva Health Community. As your doctor, I understand how debilitating a migraine or a severe headache can be. It’s not just a “headache”—it’s a neurological storm that can stop your life in its tracks. Whether it’s the throbbing pain on one side of your head, sensitivity to light, or that nauseating feeling, you deserve relief. Let’s dive deep into understanding your triggers and the medical management that can help you regain control. Understanding Your Triggers: The Root Cause Migraines are often triggered by specific factors. Identifying these is your first step toward prevention. Common triggers in the Indian context include: Dietary Triggers: Skipping meals, eating too much masala (spices), or consuming aged cheese, processed meats, or fermented foods. Even chai or coffee withdrawal can be a trigger. Hormonal Changes: Many women experience migraines around their menstrual cycle due to fluctuating estrogen levels. Environmental Factors: Bright sunlight, strong smells (like agarbatti or perfumes), pollution, or sudden weather changes. Stress & Sleep: High stress from work, family, or exams, along with irregular sleep patterns (sleeping too little or too much), are major triggers. Dehydration & Heat: Not drinking enough water, especially during Indian summers, can easily trigger a headache. Medical Management: What Actually Works? When a migraine strikes, don’t just “bear the pain.” Here’s a step-by-step medical approach: Immediate Relief (Acute Treatment) Over-the-Counter (OTC) Medications: Paracetamol (Crocin) or Ibuprofen (Brufen) can help for mild attacks. But for severe migraines, these may not be enough. Prescription Medications: Your doctor may prescribe Triptans (like Sumatriptan or Rizatriptan) which are gold-standard for migraines. They work by constricting blood vessels in the brain. Anti-nausea drugs: If vomiting is a problem, Domperidone or Metoclopramide can help. Rest in a Dark, Quiet Room: This is not a luxury—it’s essential. Close the curtains, avoid screens, and apply a cold compress to your forehead or neck. Preventive (Prophylactic) Treatment If you have 4 or more migraine attacks per month, your doctor may recommend daily preventive medications. These include: Beta-blockers like Propranolol (often used for high BP but excellent for migraines). Antidepressants like Amitriptyline (in low doses). Antiepileptics like Topiramate or Valproate. Botox injections for chronic migraines (approved by experts). Home Remedies & Diet: Your Daily Shield Alongside medical treatment, these simple Indian remedies can make a huge difference: Stay Hydrated: Drink at least 8-10 glasses of water daily. Add a pinch of sendha namak (rock salt) and lemon for electrolytes. Ginger Tea: Boil fresh ginger in water. Ginger has anti-inflammatory properties and can reduce nausea. Adrak ki chai is a powerful ally. Magnesium-Rich Foods: Eat pumpkin seeds, almonds, spinach, and bananas. Magnesium deficiency is linked to migraines. Cold Compress: Wrap ice in a cloth and place it on your forehead or temples for 15 minutes. It numbs the pain and reduces blood flow. Peppermint Oil: Apply a drop of peppermint oil diluted with coconut oil on your temples. It has a cooling, pain-relieving effect. Avoid Processed Foods: Cut down on maida (refined flour), packaged chips, and sugary drinks. These can trigger inflammation. When to See a Doctor Immediately While most headaches are benign, you must seek urgent medical help if you experience: A sudden, explosive headache (like a “thunderclap”). Headache with fever, stiff neck, or rash. Headache after a head injury. Weakness on one side of the body, slurred speech, or vision loss. New headaches after age 50. Remember, you are not alone. Migraine is a medical condition, not a character flaw. With the right triggers management and medical plan, you can live a full, pain-free life. Stay strong, stay informed, and always consult your doctor before starting any new treatment. Take care of your astitva—your existence—because your health is your greatest wealth.

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