anatryl plus tablet - Paracetamol (500mg) + Chlorpheniramine Maleate (4mg) medicine

anatryl plus tablet

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🏭 Aan Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is anatryl plus tablet used for?

This medicine contains Paracetamol (500mg) + Chlorpheniramine Maleate (4mg) and is used to treat RESPIRATORY. Paracetamol: Inhibits COX in CNS, reducing prostaglandin synthesis; Chlorpheniramine: H1-receptor an. Always consult your doctor before use.

  • Generic Name: Paracetamol + Chlorpheniramine Maleate
  • Manufacturer: Aan Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 anatryl plus tablet Uses & Benefits

Fever, headache, common cold symptoms, allergic rhinitis

Off-label uses: None commonly reported

📋 Drug Information

Generic Name(s)Paracetamol + Chlorpheniramine Maleate
Brand NameAnatryl Plus Tablet
ManufacturerAan Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntipyretic, Analgesic, Antihistamine
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly and completely absorbed from the gastrointestinal tract
DistributionWidely distributed throughout body fluids; crosses placenta
Protein BindingParacetamol: 10-25%; Chlorpheniramine: 70%
MetabolismParacetamol: Hepatic via glucuronidation and sulfation; Chlorpheniramine: Hepatic via CYP450
Half-LifeParacetamol: 1-4 hours; Chlorpheniramine: 12-15 hours
ExcretionParacetamol: Renal (mostly metabolites); Chlorpheniramine: Renal
BioavailabilityParacetamol: 60-90%; Chlorpheniramine: 25-50%
Onset of ActionParacetamol: 30-60 min; Chlorpheniramine: 1-2 hours
Peak Plasma TimeParacetamol: 0.5-2 hours; Chlorpheniramine: 2-6 hours
Duration of ActionParacetamol: 4-6 hours; Chlorpheniramine: 4-6 hours

How It Works

Paracetamol: Inhibits COX in CNS, reducing prostaglandin synthesis; Chlorpheniramine: H1-receptor antagonist

Mechanism Steps

1Paracetamol inhibits cyclooxygenase (COX) in the central nervous system, reducing prostaglandin synthesis
2Decreased prostaglandins lead to reduced pain perception and fever
3Chlorpheniramine competitively blocks histamine H1 receptors
4Blockade of H1 receptors reduces allergic symptoms such as sneezing, rhinorrhea, and itching
5Chlorpheniramine also has anticholinergic and sedative effects

💡 How to Take anatryl plus tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of anatryl plus tablet

✅ Common Side Effects

Drowsiness
Dry mouth
Nausea
Dizziness
Headache

🚨 Serious Side Effects

Hepatotoxicity
Hypersensitivity reactions
Blood dyscrasias
Respiratory depression

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Pancreatitis
Agranulocytosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major Hypertensive crisis
Alcohol Major Increased hepatotoxicity risk
Warfarin Major Increased INR and bleeding risk
Isoniazid Major Increased hepatotoxicity risk
Anticholinergics Moderate Additive anticholinergic effects
CNS depressants Moderate Enhanced sedation
Phenytoin Moderate Decreased paracetamol efficacy
Oral contraceptives Minor Decreased chlorpheniramine efficacy
Probenecid Minor Increased paracetamol levels

🚨 Major Interactions

  • MAOIs
  • Alcohol
  • Warfarin
  • Isoniazid

⚡ Moderate Interactions

  • Anticholinergics
  • CNS depressants
  • Phenytoin

🍷 Alcohol Interaction

Increased risk of hepatotoxicity with paracetamol

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, severe hepatic impairment, MAOI use, acute asthma attack

🤱 Lactation Safety

Excreted in breast milk; use with caution

💊 Overdose Management

Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care

⏰ Missed Dose

Take as soon as remembered; skip if near next dose; do not double

🔄 Substitutes for anatryl plus tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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