Amitryp-Plus Tablet - Uses, Price, Side Effects, Interactions
What is amitryp-plus tablet used for?
Amitryp-Plus Tablet contains Amitriptyline (12.5mg) and Chlordiazepoxide (5mg). It is used to treat anxiety, depression, and neuropathic pain. Amitriptyline works by increasing serotonin and norepinephrine levels, while Chlordiazepoxide enhances GABA activity to produce calming effects. This combination helps relieve pain and improve mood.
- Generic Name: Amitriptyline + Chlordiazepoxide
- Manufacturer: Biologic Psychotropics India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ amitryp-plus tablet Uses & Benefits
Depression with anxiety, mixed anxiety-depressive disorder
Off-label uses: Chronic pain, fibromyalgia, insomnia, panic disorder
๐ Drug Information
| Generic Name(s) | Amitriptyline + Chlordiazepoxide |
| Brand Name | Amixide-H Tablet |
| Manufacturer | Biologic Psychotropics India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressant + Benzodiazepine |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amitriptyline inhibits reuptake of serotonin and norepinephrine; Chlordiazepoxide enhances GABA-A receptor activity
Mechanism Steps
๐ก How to Take amitryp-plus tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of amitryp-plus tablet
โ Common Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Dizziness
๐จ Serious Side Effects
- QT prolongation
- Seizures
- Serotonin syndrome
- Suicidal ideation
- Respiratory depression
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Cholestatic jaundice
- Paradoxical excitement
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CNS Depressants | Major | Increased sedation and respiratory depression |
| Anticholinergics | Moderate | Additive anticholinergic effects |
| Warfarin | Moderate | Increased anticoagulant effect |
๐จ Major Interactions
- MAOIs
- CNS depressants
- Anticholinergics
- QT-prolonging agents
โก Moderate Interactions
- CYP2D6 inhibitors
- CYP3A4 inhibitors
- Antihypertensives
โน๏ธ Minor Interactions
- Oral contraceptives
- Smoking
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice (increases chlordiazepoxide levels)
๐ท Alcohol Interaction
Enhanced CNS depression; avoid alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Recent MI, narrow-angle glaucoma, urinary retention, MAOI use within 14 days, hypersensitivity
๐ Monitoring Parameters
ECG, liver function, mental status, blood pressure, heart rate
๐คฑ Lactation Safety
Not recommended; excreted in breast milk
๐ Overdose Management
Activated charcoal, supportive care, physostigmine for anticholinergic symptoms, flumazenil for benzodiazepine reversal (use with caution)
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Good quality medicine. Satisfied with the outcome.
Effective and reliable. Worked as expected.
Found this to be a helpful product. Good results.
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.