aptric 12.5mg/5mg tablet
What is aptric 12.5mg/5mg tablet used for?
Amixide-H Tablet (Amitriptyline + Chlordiazepoxide) is used to treat NEURO CNS. It contains Amitriptyline (12.5mg) + Chlordiazepoxide (5mg), which Amitriptyline inhibits reuptake of serotonin and norepinephrine; Chlordiazepoxid. Always consult your doctor before use. Take as prescribed.
- Generic Name: Amitriptyline + Chlordiazepoxide
- Manufacturer: Aps Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ aptric 12.5mg/5mg tablet Uses & Benefits
Depression with anxiety, mixed anxiety-depressive disorder
Off-label uses: Chronic pain, fibromyalgia, insomnia, panic disorder
๐ Drug Information
| Generic Name(s) | Amitriptyline + Chlordiazepoxide |
| Brand Name | Amixide-H Tablet |
| Manufacturer | Aps Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressant + Benzodiazepine |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amitriptyline inhibits reuptake of serotonin and norepinephrine; Chlordiazepoxide enhances GABA-A receptor activity
Mechanism Steps
๐ก How to Take aptric 12.5mg/5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of aptric 12.5mg/5mg tablet
โ Common Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Dizziness
๐จ Serious Side Effects
- QT prolongation
- Seizures
- Serotonin syndrome
- Suicidal ideation
- Respiratory depression
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Cholestatic jaundice
- Paradoxical excitement
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CNS depressants | Major | Additive sedation, respiratory depression |
| Warfarin | Moderate | Increased anticoagulant effect |
| Grapefruit juice | Moderate | Increased chlordiazepoxide levels |
๐จ Major Interactions
- MAOIs
- CNS depressants
- Anticholinergics
- QT-prolonging agents
โก Moderate Interactions
- CYP2D6 inhibitors
- CYP3A4 inhibitors
- Antihypertensives
โน๏ธ Minor Interactions
- Oral contraceptives
- Smoking
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice (increases chlordiazepoxide levels)
๐ท Alcohol Interaction
Enhanced CNS depression; avoid alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Recent MI, narrow-angle glaucoma, urinary retention, MAOI use within 14 days, hypersensitivity
๐ Monitoring Parameters
ECG, liver function, mental status, blood pressure, heart rate
๐คฑ Lactation Safety
Not recommended; excreted in breast milk
๐ Overdose Management
Activated charcoal, supportive care, physostigmine for anticholinergic symptoms, flumazenil for benzodiazepine reversal (use with caution)
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Helpful and effective medicine as per my experience. Always consult a doctor.
Effective and reliable. Worked as expected.
Good quality medicine. Satisfied with the outcome.
This medicine was effective for me. I followed the doctor's advice.
Helpful and effective medicine as per my experience. Always consult a doctor.