amcro 500mg injection - Amikacin (500mg) medicine

Amcro 500mg Injection - Uses, Price, Side Effects

4.5 (17 reviews)
Amikacin (500mg)
๐Ÿญ Cronus Biotech Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 23, 2026

What is amcro 500mg injection used for?

Amcro 500mg Injection contains Amikacin, an aminoglycoside antibiotic that treats serious bacterial infections by stopping bacteria from producing essential proteins, leading to bacterial death. It is used for infections like septicemia, respiratory tract infections, and complicated urinary tract infections when other antibiotics are ineffective.

  • Generic Name: Amikacin
  • Manufacturer: Cronus Biotech Ltd
  • Form: Allopathy
  • Pregnancy Category: D
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š amcro 500mg injection Uses & Benefits

Serious Gram-negative infections (sepsis, pneumonia, complicated UTI, intra-abdominal infections); adjunct in tuberculosis; neonatal sepsis.

Off-label uses: Brucellosis, Plague, Tularemia

๐Ÿ“‹ Drug Information

Generic Name(s)Amikacin
Brand NameAmikacin Sulphate 500mg Injection
ManufacturerCronus Biotech Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action ClassAminoglycosides
Route of AdministrationIntramuscular, Intravenous
StorageStore at 20-25ยฐC; protect from light; do not freeze.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intramuscular injection; peak plasma concentrations achieved within 1 hour.
DistributionDistributes widely into extracellular fluids; high concentrations in urine, bile, and synovial fluid; crosses placenta; minimal penetration into cerebrospinal fluid unless meninges inflamed.
Protein Binding0-11%
MetabolismMinimal hepatic metabolism; primarily excreted unchanged.
Half-Life2-3 hours (normal renal function); up to 30-60 hours in renal impairment.
ExcretionRenal excretion (90-98% unchanged) via glomerular filtration.
Bioavailability100% (IM); not absorbed orally.
Onset of ActionRapid (within 1 hour for IM).
Peak Plasma Time1 hour (IM); end of infusion (IV).
Duration of Action8-12 hours (dose-dependent).

How It Works

Binds to 30S ribosomal subunit, causing misreading of mRNA and inhibition of protein synthesis.

Mechanism Steps

1Binds to 30S ribosomal subunit
2Interferes with initiation complex
3Causes misreading of mRNA codons

๐Ÿ’ก How to Take amcro 500mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of amcro 500mg injection

โœ… Common Side Effects

  • Nephrotoxicity
  • Ototoxicity (vestibular and cochlear)
  • Nausea
  • Vomiting
  • Rash

๐Ÿšจ Serious Side Effects

  • Acute renal failure
  • Irreversible hearing loss
  • Neuromuscular blockade
  • Anaphylaxis

โš ๏ธ Rare Side Effects

  • Superinfection
  • Clostridium difficile colitis
  • Hypomagnesemia

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Loop Diuretics Moderate Increased nephrotoxicity
Neuromuscular Blockers Major Enhanced neuromuscular blockade

๐Ÿšจ Major Interactions

  • Neuromuscular blocking agents
  • Other aminoglycosides
  • Cisplatin
  • Loop diuretics
  • Vancomycin

โšก Moderate Interactions

  • Penicillins (synergy)
  • Cephalosporins
  • NSAIDs
  • Methoxyflurane

โ„น๏ธ Minor Interactions

  • Dimercaprol
  • Indomethacin

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Moderate
Heart
Low
Pregnancy
Category D

๐Ÿšซ Contraindications

Hypersensitivity to amikacin or other aminoglycosides; myasthenia gravis; pre-existing severe renal impairment.

๐Ÿ“Š Monitoring Parameters

Renal function (serum creatinine, BUN), urine output, audiometry, serum drug levels (peak and trough).

๐Ÿคฑ Lactation Safety

Caution; small amounts excreted in breast milk; monitor infant for diarrhea, candidiasis.

๐Ÿ’Š Overdose Management

Supportive care; hemodialysis may enhance elimination; monitor renal function and hearing.

โฐ Missed Dose

Administer as soon as remembered; if near next dose, skip missed dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for amcro 500mg injection

View All

Alternative brands with exact same active ingredient (Amikacin (500mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

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