cachmik 500mg injection

4.7 (10 reviews)

Amikacin (500mg)

🏭 Cachet Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is cachmik 500mg injection used for?

Amikacin Sulphate 500mg Injection (Amikacin) is used to treat OPHTHAL. It contains Amikacin (500mg), which Binds to 30S ribosomal subunit, causing misreading of mRNA and inhibition of pro. Always consult your doctor before use. Take as prescribed.

Generic Name: Amikacin
Manufacturer: Cachet Pharmaceuticals Pvt Ltd
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 cachmik 500mg injection Uses & Benefits

Serious Gram-negative infections (sepsis, pneumonia, complicated UTI, intra-abdominal infections); adjunct in tuberculosis; neonatal sepsis.

Off-label uses: Brucellosis, Plague, Tularemia

📋 Drug Information

Generic Name(s)	Amikacin
Brand Name	Amikacin Sulphate 500mg Injection
Manufacturer	Cachet Pharmaceuticals Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	OPHTHAL
Action Class	Aminoglycosides
Route of Administration	Intramuscular, Intravenous
Storage	Store at 20-25°C; protect from light; do not freeze.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intramuscular injection; peak plasma concentrations achieved within 1 hour.

DistributionDistributes widely into extracellular fluids; high concentrations in urine, bile, and synovial fluid; crosses placenta; minimal penetration into cerebrospinal fluid unless meninges inflamed.

Protein Binding0-11%

MetabolismMinimal hepatic metabolism; primarily excreted unchanged.

Half-Life2-3 hours (normal renal function); up to 30-60 hours in renal impairment.

ExcretionRenal excretion (90-98% unchanged) via glomerular filtration.

Bioavailability100% (IM); not absorbed orally.

Onset of ActionRapid (within 1 hour for IM).

Peak Plasma Time1 hour (IM); end of infusion (IV).

Duration of Action8-12 hours (dose-dependent).

How It Works

Binds to 30S ribosomal subunit, causing misreading of mRNA and inhibition of protein synthesis.

Mechanism Steps

1Binds to 30S ribosomal subunit

2Interferes with initiation complex

3Causes misreading of mRNA codons

💡 How to Take cachmik 500mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of cachmik 500mg injection

✅ Common Side Effects

Nephrotoxicity
Ototoxicity (vestibular and cochlear)
Nausea
Vomiting
Rash

🚨 Serious Side Effects

Acute renal failure
Irreversible hearing loss
Neuromuscular blockade
Anaphylaxis

⚠️ Rare Side Effects

Superinfection
Clostridium difficile colitis
Hypomagnesemia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Neuromuscular blocking agents	Major	Enhanced neuromuscular blockade, respiratory depression
Cisplatin	Major	Increased nephrotoxicity and ototoxicity
Loop diuretics	Major	Increased ototoxicity
Vancomycin	Major	Increased nephrotoxicity
Penicillins	Moderate	Synergistic antibacterial effect
NSAIDs	Moderate	Increased nephrotoxicity risk

🚨 Major Interactions

Neuromuscular blocking agents
Other aminoglycosides
Cisplatin
Loop diuretics
Vancomycin

⚡ Moderate Interactions

Penicillins (synergy)
Cephalosporins
NSAIDs
Methoxyflurane

ℹ️ Minor Interactions

Dimercaprol
Indomethacin

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to amikacin or other aminoglycosides; myasthenia gravis; pre-existing severe renal impairment.

📊 Monitoring Parameters

Renal function (serum creatinine, BUN), urine output, audiometry, serum drug levels (peak and trough).

🤱 Lactation Safety

Caution; small amounts excreted in breast milk; monitor infant for diarrhea, candidiasis.

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination; monitor renal function and hearing.

⏰ Missed Dose

Administer as soon as remembered; if near next dose, skip missed dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for cachmik 500mg injection

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Alternative brands with exact same active ingredient (Amikacin (500mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.