Amexine 500mg/8mg Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Severe or bloody diarrhoea, or persistent abdominal cramps.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- A painful rash with blistering or peeling skin.
- Decreased urine output, swelling in the legs, or extreme fatigue.
- Unusual bruising or bleeding.
- High fever that does not improve after 48 to 72 hours of treatment.
- Seizures or severe confusion.
If experiencing severe symptoms, call emergency services immediately.
What is ambro 500mg/8mg capsule used for?
This medicine is a prescription antibiotic combination of amoxycillin and bromhexine used to treat bacterial respiratory infections with thick mucus. It works by killing bacteria and thinning mucus. Take it exactly as prescribed, usually every 8 hours, and complete the full course.
- Generic Name: Amoxycillin + Bromhexine
- Manufacturer: BIO Ethicals Pharma Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ambro 500mg/8mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एमोक्सिसिलिन और ब्रोमहेक्सिन का संयोजन है, जिसका उपयोग बैक्टीरियल श्वसन संक्रमण के इलाज के लिए किया जाता है, खासकर जब बलगम गाढ़ा हो और खांसी में कफ आता हो। यह ब्रोंकाइटिस, निमोनिया, साइनसाइटिस और क्रोनिक ब्रोंकाइटिस के तीव्र दौरे में प्रभावी है। एमोक्सिसिलिन बैक्टीरिया को मारता है और ब्रोमहेक्सिन बलगम को पतला करके निकालने में मदद करता है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए और पूरा कोर्स पूरा करना जरूरी है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में परेशानी, त्वचा पर चकत्ते और स्वाद में बदलाव शामिल हैं। गंभीर लेकिन दुर्लभ दुष्प्रभावों में एलर्जी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर त्वचा प्रतिक्रियाएं और दस्त शामिल हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बेहतर महसूस होने पर भी कोर्स अधूरा न छोड़ें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं, खासकर खून पतला करने वाली दवाएं, मेथोट्रेक्सेट, एलोप्यूरिनॉल और अन्य एंटीबायोटिक्स। इस दवा के साथ शराब न लें। गुर्दे या लीवर की बीमारी हो तो डॉक्टर को बताएं। बिना पर्चे के इस दवा का इस्तेमाल न करें। बच्चों की पहुंच से दूर रखें।
💊 ambro 500mg/8mg capsule Uses & Benefits
[{"condition":"Acute bacterial bronchitis","description":"Used to treat bacterial infection of the bronchi when accompanied by thick, tenacious mucus and productive cough.","evidence":"Well-established for the antibiotic component; mucolytic component has supportive evidence."},{"condition":"Acute exacerbation of chronic bronchitis","description":"Helps control bacterial infection and loosen mucus in patients with chronic obstructive pulmonary disease experiencing worsening symptoms.","evidence":"Well-established for amoxycillin; bromhexine used as adjunct."},{"condition":"Bacterial pneumonia (community-acquired, mild to moderate)","description":"May be used when a susceptible organism is suspected and mucus clearance is a concern.","evidence":"Established for amoxycillin; combination use is common in some regions."},{"condition":"Acute bacterial sinusitis","description":"Prescribed when sinus infection is bacterial and associated with thick nasal secretions.","evidence":"Established for amoxycillin; bromhexine may aid symptom relief."},{"condition":"Bronchiectasis with secondary infection","description":"Used to treat infective exacerbations and help clear purulent secretions.","evidence":"Limited to supportive; specialist supervision required."}]
Off-label uses: [{"condition":"Otitis media in adults","description":"Occasionally used off-label when a susceptible organism is confirmed and mucus thinning is desired.","evidence":"Limited"},{"condition":"Urinary tract infection","description":"Not a standard use; amoxycillin alone may be used for susceptible organisms, but bromhexine adds no benefit.","evidence":"Not recommended"}]
Primary treatment for: Bacterial respiratory tract infections
Also treats: Acute bronchitis, Chronic bronchitis exacerbation, Bacterial pneumonia, Sinusitis, Bronchiectasis
📋 Drug Information
| Generic Name(s) | Amoxycillin + Bromhexine |
| Brand Name | Amexine 500mg/8mg capsule |
| Manufacturer | BIO Ethicals Pharma Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | ANTI INFECTIVES |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Protect from light and moisture. Keep in the original container. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | Typically 24 months from the date of manufacture. Check the expiry date on the pack before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Amoxycillin is a beta-lactam antibiotic that binds to penicillin-binding proteins on the bacterial cell wall, inhibiting peptidoglycan cross-linking and causing bacterial lysis. Bromhexine is a mucolytic that reduces mucus viscosity by breaking down acidic mucopolysaccharide fibres, improving mucociliary clearance and making cough more productive.
Mechanism Steps
💡 How to Take ambro 500mg/8mg capsule
Strength: Each immediate-release capsule contains amoxycillin 500 mg and bromhexine 8 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule taken orally every 8 hours (three times a day), but the exact dose and duration depend on the type and severity of infection, your kidney and liver function, and other medical conditions. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly and complete the full course. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function and are more sensitive to the effects of amoxycillin. Dose adjustment may be necessary based on renal function. Consult your doctor for individualized dosing. |
| Renal Impairment | In patients with renal impairment, the dose of amoxycillin should be reduced or the dosing interval lengthened according to creatinine clearance. Bromhexine dose adjustment in renal impairment is not well established. Consult a nephrologist or your prescribing doctor for specific guidance. |
| Hepatic Impairment | In patients with hepatic impairment, amoxycillin is generally safe but should be used with caution. Bromhexine undergoes hepatic metabolism and may accumulate; dose reduction may be considered. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of amoxycillin for adults is typically 3 grams (3000 mg) per day, but this may vary based on the infection and renal function. The maximum daily dose of bromhexine is not well established from available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ambro 500mg/8mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Moderate | |
| Probenecid | Moderate | |
| Tetracyclines | Moderate | |
| Oral contraceptives | Moderate | |
| Aminoglycosides | Moderate | |
| Diuretics | Moderate | |
| Antitussives | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
- Probenecid
- Tetracyclines
⚡ Moderate Interactions
- Oral contraceptives
- Aminoglycosides
- Diuretics
- Bromhexine with antitussives
🍷 Alcohol Interaction
Alcohol may worsen stomach upset and liver stress while taking this medicine. It is advisable to avoid alcohol during the course of treatment, especially if you have liver disease or are taking other medications that affect the liver.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to penicillins, cephalosporins, or bromhexine.","Previous severe allergic reaction to any beta-lactam antibiotic.","Severe renal impairment without dose adjustment.","Severe hepatic impairment without specialist supervision.","Use in patients with rare hereditary galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.","Concurrent use with live typhoid vaccine (amoxycillin may inactivate it)."]
⚠️ Warnings & Precautions
["Before starting, inform your doctor about all allergies, especially to antibiotics.","Use with caution in patients with kidney or liver disease; dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May reduce the effectiveness of oral contraceptives; use backup contraception.","Do not use for viral infections; it will not help and may cause harm.","Complete the full prescribed course even if you feel better.","Avoid alcohol during treatment.","If a rash or severe diarrhoea occurs, stop the medicine and contact your doctor immediately."]
🤱 Lactation Safety
Amoxycillin is excreted in breast milk in small amounts and is generally considered compatible with breastfeeding. Bromhexine may also pass into breast milk; its effects on the nursing infant are not well established. Consult your doctor before use while breastfeeding.
💊 Overdose Management
Overdose may cause nausea, vomiting, diarrhoea, and abdominal pain. In severe cases, crystalluria, seizures, or kidney failure may occur. There is no specific antidote. Treatment is supportive and symptomatic. Maintain good hydration. If overdose is suspected, contact a poison control centre or go to the nearest emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop early even if you feel better, as this can allow the infection to return and encourage antibiotic resistance. Inform your doctor about all other medicines, especially blood thinners, methotrexate, allopurinol, probenecid, and other antibiotics. Avoid alcohol while taking this medicine because it can worsen stomach upset and liver stress. If you have kidney or liver problems, your doctor may need to adjust the dose. Do not use this medicine for a viral infection or without a prescription. Keep out of reach of children. If you experience a rash, swelling, or difficulty breathing, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can affect the elimination of amoxycillin and increase the risk of side effects. Dose adjustment may be necessary. They may also be more susceptible to severe diarrhoea and allergic reactions. Monitor closely and consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss this medicine with your doctor before conception. Amoxycillin is generally considered safe, but bromhexine is not recommended in early pregnancy. Your doctor may recommend an alternative antibiotic if needed. Do not start or stop any medicine without medical advice.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with other medications used during surgery. Your doctor may advise you to stop the medicine before surgery or adjust the dose. Follow your surgical team's instructions carefully.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may affect the choice of antibiotics or interact with other medications used. Your dentist may coordinate with your doctor to ensure safe treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel tired or weak due to the infection. Avoid strenuous exercise until you have recovered. Light activity such as walking is generally fine if you feel up to it. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. If you experience these effects, avoid driving or operating heavy machinery until you feel better. Most people can continue their usual daily activities, but adequate rest is important for recovery. Stay home if you have a fever or are feeling unwell to avoid spreading infection.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full prescribed course, even if you feel better. If you experience a severe allergic reaction, severe diarrhoea, or any other serious side effect, stop immediately and seek medical attention. Do not stop early without consulting your doctor, as this can lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless specifically directed by a doctor. Prolonged antibiotic use can lead to bacterial resistance, fungal overgrowth, and rare blood or liver abnormalities. If long-term therapy is necessary, your doctor will monitor your kidney and liver function, complete blood count, and signs of superinfection. Always discuss the risks and benefits with your doctor before extending treatment beyond the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and relieve congestion naturally.
Evidence: SupportiveCan help clear nasal passages and reduce congestion in sinusitis.
Evidence: Well-established for symptom reliefTechniques to help clear mucus from the lungs, especially in chronic lung disease.
Evidence: Well-established as adjunctCan soothe sore throat and reduce cough frequency.
Evidence: Limited but supportive💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines such as the typhoid vaccine. Avoid taking live typhoid vaccine while on this antibiotic. Inactivated vaccines are generally safe to receive. Consult your doctor for specific timing recommendations.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless specified.
✅ DO
Keep in the original container with the lid tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing times gradually to maintain even intervals, but consult your doctor for specific advice. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel better within 24 to 72 hours, but it is important to complete the full prescribed course, which is usually 5 to 10 days, to ensure the infection is fully treated.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset and nausea.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Amoxycillin is generally considered safe during pregnancy when prescribed by a doctor. Bromhexine is not recommended in the first trimester. Consult your obstetrician before taking this medicine.
A: It is best to avoid alcohol during treatment as it can worsen stomach upset and liver stress.
A: Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and out of reach of children.
🤔 Common Patient Concerns
🔄 Substitutes for ambro 500mg/8mg capsule
View AllAlternative brands with exact same active ingredient:
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mycocin forte capsuleAdcock Ingram Healthcare Pvt Ltd ₹37.75 41.9% CHEAPER
-
bromolin 500 mg/8 mg capsuleCipla Ltd ₹51.88 20.2% CHEAPER
-
amexine 500mg/8mg capsulePfizer Ltd ₹55.57 14.5% CHEAPER
-
Trimox BX 500mg/8mg TabletMapra Laboratories Pvt Ltd ₹59.50 8.5% CHEAPER
-
ambrox forte 500mg/8mg capsuleCyper Drugs & Pharmaceuticals Pvt Ltd ₹65.00 SAME PRICE
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: The common cold is usually viral, and this antibiotic combination does not work against viruses. It is only effective for bacterial infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full prescribed course to ensure all bacteria are killed and to prevent resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription-only antibiotic. Misuse can lead to resistance and side effects. Always consult a doctor. - Myth: Taking antibiotics with alcohol is always dangerous.
Fact: While alcohol does not directly interact with amoxycillin, it can worsen stomach upset and liver stress. It is best to avoid alcohol during treatment.
🔄 Alternative Options
Generic Alternatives
- Amoxycillin + Bromhexine generic
Brand Alternatives
- Amexine 500mg/8mg capsule