ampi 1000mg injection

4.7 (13 reviews)

Ampicillin (1000mg)

🏭 Shalina Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is ampi 1000mg injection used for?

Ampilin (Ampicillin) is used to treat ANTI INFECTIVES. It contains Ampicillin (1000mg), which Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Always consult your doctor before use. Take as prescribed.

Generic Name: Ampicillin
Manufacturer: Shalina Laboratories Pvt Ltd
Form: Allopathy
Pregnancy Category: B
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 ampi 1000mg injection Uses & Benefits

Respiratory tract infections, urinary tract infections, meningitis, septicemia, endocarditis, skin and soft tissue infections.

Off-label uses: Prophylaxis for bacterial endocarditis, Lyme disease

📋 Drug Information

Generic Name(s)	Ampicillin
Brand Name	Ampilin
Manufacturer	Shalina Laboratories Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Cell wall active agent -Extended spectrum Penicillin
Route of Administration	Intramuscular (IM) or Intravenous (IV)
Storage	Store at 20-25°C (68-77°F); reconstituted solution stable for 1 hour at room temperature.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after intramuscular injection; oral absorption is variable but not applicable for injection.

DistributionDistributes widely into body tissues and fluids, including cerebrospinal fluid (inflamed meninges).

Protein Binding15-25%

MetabolismPartially metabolized in the liver to penicilloic acid.

Half-Life1-1.8 hours (prolonged in renal impairment)

ExcretionPrimarily excreted unchanged in urine (90%) via glomerular filtration and tubular secretion.

Bioavailability100% (IM/IV)

Onset of ActionRapid (within minutes after IV)

Peak Plasma Time30-60 minutes after IM injection

Duration of Action6-8 hours

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis.

Mechanism Steps

1Binds to penicillin-binding proteins (PBPs) on bacterial cell wall

2Inhibits transpeptidase activity, preventing cross-linking of peptidoglycan

3Activates autolytic enzymes (autolysins) in bacterial cell wall

💡 How to Take ampi 1000mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of ampi 1000mg injection

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Rash
Injection site pain

🚨 Serious Side Effects

Anaphylaxis
Pseudomembranous colitis
Seizures
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Hemolytic anemia
Interstitial nephritis
Agranulocytosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Methotrexate	Major	Increased methotrexate toxicity
Warfarin	Major	Increased bleeding risk
Oral contraceptives	Major	Reduced contraceptive efficacy
Probenecid	Major	Increased ampicillin levels
Allopurinol	Moderate	Increased risk of skin rash
Aminoglycosides	Moderate	Synergistic effect, but incompatible in same IV solution
Chloramphenicol	Moderate	Antagonistic effect
Tetracyclines	Minor	Possible reduced efficacy
Sulfonamides	Minor	Possible reduced efficacy

🚨 Major Interactions

Methotrexate
Warfarin
Oral contraceptives
Probenecid

⚡ Moderate Interactions

Allopurinol
Aminoglycosides
Chloramphenicol

ℹ️ Minor Interactions

Tetracyclines
Sulfonamides

🍽️ Food Interactions

No significant food interactions with injection

🍷 Alcohol Interaction

No direct interaction, but alcohol may reduce immune response.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to penicillins, cephalosporins, or any component of the formulation.

📊 Monitoring Parameters

Renal function, hepatic function, CBC, signs of hypersensitivity, superinfection.

🤱 Lactation Safety

Compatible; excreted in small amounts in breast milk, unlikely to harm infant.

💊 Overdose Management

Supportive care; hemodialysis may help remove ampicillin.

⏰ Missed Dose

Administer as soon as possible; skip if almost time for next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for ampi 1000mg injection

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Alternative brands with exact same active ingredient (Ampicillin (1000mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.