Amazil 5mg Tablet - Uses, Price, Side Effects
What is amazil 5mg tablet used for?
Amazil 5mg Tablet contains Donepezil, a cholinesterase inhibitor used to treat symptoms of Alzheimer's disease. It works by increasing levels of acetylcholine in the brain, which helps improve memory, awareness, and cognitive function. It is typically taken once daily at bedtime.
- Generic Name: Donepezil
- Manufacturer: Emcure Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amazil 5mg tablet Uses & Benefits
Mild to moderate Alzheimer's disease; also used for severe Alzheimer's disease.
Off-label uses: Vascular dementia, Lewy body dementia, cognitive impairment in Parkinson's disease.
๐ Drug Information
| Generic Name(s) | Donepezil |
| Brand Name | Aricep 5 Tablet |
| Manufacturer | Emcure Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Cholinesterase inhibitors - Alzheimer's disease |
| Route of Administration | Oral. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Reversible inhibition of acetylcholinesterase, increasing acetylcholine levels in the brain.
Mechanism Steps
๐ก How to Take amazil 5mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of amazil 5mg tablet
โ Common Side Effects
- Nausea
- Diarrhea
- Insomnia
- Fatigue
- Muscle cramps
- Anorexia
๐จ Serious Side Effects
- Bradycardia
- Syncope
- Gastrointestinal bleeding
- Seizures
- QT prolongation
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Neuroleptic malignant syndrome
- Rhabdomyolysis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| NSAIDs | Moderate | Increased risk of gastrointestinal bleeding |
| Anticholinergics | Moderate | Reduced efficacy of donepezil |
| Succinylcholine | Major | Prolonged neuromuscular blockade |
๐จ Major Interactions
- Anticholinergic drugs
- Cholinergic agonists
- Succinylcholine
- NSAIDs
โก Moderate Interactions
- CYP2D6 inhibitors
- CYP3A4 inhibitors
- CYP2D6 inducers
- CYP3A4 inducers
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
๐ฝ๏ธ Food Interactions
Food delays absorption but does not affect overall bioavailability.
๐ท Alcohol Interaction
Alcohol may increase CNS depression; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to donepezil or piperidine derivatives; history of gastrointestinal bleeding; sick sinus syndrome or other supraventricular conduction abnormalities.
๐ Monitoring Parameters
Cognitive function, behavior, heart rate, gastrointestinal symptoms, weight.
๐คฑ Lactation Safety
Not recommended; excreted in animal milk, unknown in humans.
๐ Overdose Management
Supportive care; atropine for cholinergic crisis; monitor for bradycardia and seizures.
โฐ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose; do not double.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for amazil 5mg tablet
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Medical Note: Always consult your doctor before switching medications.