donaz 5mg tablet - Donepezil (5mg) medicine

Aricep 5 Tablet (donepezil 5mg): Complete Medicine Guide

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🏭 Glenmark Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 28, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established
Reviewed by
SaathiMed Expert Panel | Oct 28, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Fainting or severe dizziness
  • Irregular or very slow heartbeat
  • Seizures or convulsions
  • Black, tarry stools or vomiting blood
  • Difficulty urinating or inability to urinate
  • Severe abdominal pain
  • Signs of allergic reaction such as rash, itching, swelling of face, lips, or throat
  • Fever with muscle rigidity and confusion

If experiencing severe symptoms, call emergency services immediately.

What is donaz 5mg tablet used for?

This medicine is a 5 mg donepezil tablet used to treat Alzheimer's disease. It works by increasing acetylcholine in the brain to improve memory and thinking. It is taken once daily at bedtime.

  • Generic Name: Donepezil
  • Manufacturer: Glenmark Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 donaz 5mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डोनेपेज़िल 5 मिलीग्राम टैबलेट है, जिसका उपयोग अल्जाइमर रोग के इलाज के लिए किया जाता है। यह मस्तिष्क में एसिटाइलकोलीन नामक रसायन को बढ़ाकर याददाश्त और सोचने की क्षमता में सुधार करने में मदद करती है। यह दवा अल्जाइमर रोग के लक्षणों को कम करने में सहायक हो सकती है, लेकिन यह बीमारी का इलाज नहीं है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, दस्त, उल्टी, भूख में कमी, सिरदर्द, अनिद्रा और थकान शामिल हैं। गंभीर दुष्प्रभावों में धीमी हृदय गति, दौरे, पेट में रक्तस्राव और मूत्र त्याग में कठिनाई हो सकती है। यदि आपको कोई गंभीर दुष्प्रभाव महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से हृदय रोग, पेट के अल्सर, अस्थमा या दौरे। अपनी सभी दवाओं की सूची प्रदान करें। इस दवा को डॉक्टर के निर्देशानुसार ही लें, आमतौर पर रात को सोने से पहले एक बार। यदि आपको चक्कर आते हैं या नींद आती है, तो वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 donaz 5mg tablet Uses & Benefits

  • [{"condition":"Alzheimer's disease","description":"This medicine is used to treat mild, moderate, and severe dementia of the Alzheimer's type.
  • It helps improve cognitive function and daily living activities.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Lewy body dementia","description":"Sometimes prescribed off-label to manage cognitive symptoms in Lewy body dementia.","evidence":"Limited"},{"condition":"Vascular dementia","description":"May be used off-label for cognitive impairment associated with vascular dementia, though evidence is mixed.","evidence":"Limited"},{"condition":"Traumatic brain injury","description":"Occasionally used off-label to improve cognitive function after traumatic brain injury.","evidence":"Insufficient"}]

Primary treatment for: Alzheimer's disease

Also treats: Lewy body dementia, Vascular dementia

📋 Drug Information

Generic Name(s)Donepezil
Brand NameAricep 5 Tablet
ManufacturerGlenmark Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassCholinesterase inhibitors - Alzheimer's disease
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F and 86°F). Keep away from moisture and heat.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at bedtime to reduce the risk of nausea and other gastrointestinal side effects.
2
Monitor for slow heartbeat, especially if the patient is also taking beta-blockers or has a history of heart disease.
3
Encourage the patient to stay hydrated and eat small, frequent meals if they experience loss of appetite.
4
Regularly assess cognitive function and behavioral symptoms to evaluate the effectiveness of the treatment.
5
Advise patients to avoid driving or operating heavy machinery until they know how this medicine affects them.
6
Instruct patients not to stop the medication abruptly without consulting you, as this may lead to worsening of symptoms.
7
Be cautious when prescribing this medicine to patients with a history of peptic ulcer disease or those taking NSAIDs.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Memory loss
This medicine is commonly prescribed for memory loss associated with Alzheimer's disease.
Likely Use
✅
Confusion
May help with confusion in Alzheimer's patients.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary
❌
Headache
This medicine is not indicated for headache relief.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 100%.
DistributionThis medicine is widely distributed throughout the body, including the central nervous system. It crosses the blood-brain barrier.
Protein BindingApproximately 96% of this medicine is bound to plasma proteins, primarily albumin and alpha-1-acid glycoprotein.
MetabolismThis medicine is extensively metabolized in the liver, primarily by cytochrome P450 enzymes CYP2D6 and CYP3A4, and to a lesser extent by CYP1A2. It undergoes glucuronidation as well. The main metabolites are 6-O-desmethyl donepezil and donepezil-cis-N-oxide.
Half-LifeThe elimination half-life of this medicine is approximately 70 hours.
ExcretionThis medicine and its metabolites are primarily excreted in the urine (about 57%) and feces (about 15%).
BioavailabilityThe absolute bioavailability of this medicine is approximately 100%.
Onset of ActionThe onset of action for this medicine is gradual, with clinical effects typically observed after several weeks of treatment.
Peak Plasma TimeThe peak plasma concentration of this medicine is reached approximately 3 to 4 hours after oral administration.
Duration of ActionThe duration of action of this medicine is not precisely defined, but its long half-life allows for once-daily dosing.

How It Works

This medicine is a reversible inhibitor of acetylcholinesterase, the enzyme responsible for breaking down acetylcholine in the brain. By inhibiting this enzyme, it increases the concentration of acetylcholine at cholinergic synapses, enhancing cholinergic neurotransmission. This action is thought to be responsible for the symptomatic benefits in Alzheimer's disease.

Mechanism Steps

1
Inhibition of acetylcholinesterase: This medicine binds reversibly to acetylcholinesterase, preventing the breakdown of acetylcholine.
2
Increased acetylcholine levels: As a result of enzyme inhibition, acetylcholine accumulates in the synaptic cleft.
3
Enhanced cholinergic transmission: The increased acetylcholine binds to muscarinic and nicotinic receptors, improving neuronal communication.
4
Symptomatic improvement: This enhanced transmission may lead to temporary improvements in memory, thinking, and behavior in Alzheimer's patients.

💡 How to Take donaz 5mg tablet

Strength: 5 mg immediate-release tablet

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3Take it at bedtime to minimize side effects like nausea.
4You can take it with or without food, but taking it with food may reduce stomach upset.
5Do not crush, chew, or break the tablet unless your doctor advises otherwise.
6If you miss a dose, follow the missed dose instructions.
7Do not stop taking this medicine abruptly without consulting your doctor.

Dosage Information

Adult DosageThe recommended initial dose of this medicine for adults is 5 mg taken once daily at bedtime. After 4 to 6 weeks, the dose may be increased to 10 mg once daily if tolerated and clinically indicated. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dosage adjustments are required for elderly patients based on age alone. However, elderly patients may be more sensitive to the effects of this medicine, and dose should be individualized by a qualified clinician.
Renal ImpairmentNo dosage adjustment is necessary for patients with renal impairment, as this medicine is primarily metabolized in the liver.
Hepatic ImpairmentDose adjustment may be necessary in patients with hepatic impairment. Consult a qualified clinician for individualized dosing.
Maximum Daily Dose10 mg per day

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food
Can be taken with or without food
Food does not significantly affect absorption, but taking with food may reduce nausea.
Grapefruit juice
Avoid
May increase drug levels by inhibiting CYP3A4.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of donaz 5mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Diarrhea (Common (5-10%))
Stay hydrated. If diarrhea is severe or persistent, contact your doctor.
Vomiting (Common (5-10%))
Take with food. If vomiting continues, consult your doctor.
Loss of appetite (Common (5-10%))
Eat small, frequent meals. Monitor weight.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Insomnia (Common (5-10%))
Take in the morning if insomnia occurs, but consult your doctor first.
Fatigue (Common (5-10%))
Rest when needed. If severe, consult your doctor.
Muscle cramps (Common (5-10%))
Stay hydrated and stretch gently. Consult doctor if persistent.

🚨 Serious Side Effects

Bradycardia (Uncommon (0.1-1%))
Seek immediate medical attention if you experience fainting, dizziness, or irregular heartbeat.
Seizures (Rare (<0.1%))
Call emergency services if a seizure occurs.
Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Neuroleptic malignant syndrome (Very rare (<0.01%))
Go to the emergency room if you experience fever, muscle rigidity, confusion, or autonomic instability.
Difficulty urinating (Uncommon (0.1-1%))
Consult your doctor if you have trouble urinating.

⚠️ Rare Side Effects

Hallucinations
Consult your doctor if you experience hallucinations.
Agitation
Report to your doctor for assessment.
Abnormal dreams
Discuss with your doctor if bothersome.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Anticholinergics Major
Beta-blockers Major
Cholinergic agonists Major
CYP2D6 inhibitors Moderate
CYP3A4 inhibitors Moderate
CYP3A4 inducers Moderate
NSAIDs Minor
Warfarin Minor
Grapefruit juice Moderate
Alcohol Moderate

🚨 Major Interactions

  • Anticholinergic drugs (e.g., atropine, benztropine)
  • Beta-blockers (e.g., propranolol)
  • Cholinergic agonists (e.g., bethanechol)

⚡ Moderate Interactions

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
  • CYP3A4 inducers (e.g., rifampin, carbamazepine)

🍷 Alcohol Interaction

Alcohol may increase drowsiness and dizziness caused by this medicine. It is advisable to avoid or limit alcohol consumption while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to donepezil or any component of the formulation","Sick sinus syndrome or other supraventricular cardiac conduction abnormalities, unless a pacemaker is present"]

⚠️ Warnings & Precautions

["This medicine may cause bradycardia; monitor heart rate closely.","May increase gastric acid secretion; caution in patients with a history of ulcer disease.","May cause seizures; caution in patients with a history of seizure disorder.","May cause difficulty urinating; caution in patients with urinary outflow obstruction.","May cause dizziness and drowsiness; avoid driving or operating machinery until effects are known.","Use with caution in patients with asthma or obstructive pulmonary disease.","May cause weight loss; monitor weight regularly."]

🤱 Lactation Safety

It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman.

💊 Overdose Management

Overdose with this medicine can cause cholinergic crisis, characterized by severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, and seizures. Treatment is symptomatic and supportive. Atropine may be used as an antidote for severe bradycardia or cholinergic symptoms. Immediate medical attention should be sought in case of overdose.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Before starting this medicine, inform your doctor about all your medical conditions, especially heart problems, stomach ulcers, asthma, or seizures. Also, provide a complete list of all medications you are taking, including prescription, over-the-counter, and herbal supplements. Do not start or stop this medicine without consulting your doctor. Take this medicine exactly as prescribed, usually once daily at bedtime. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. This medicine may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you. Avoid alcohol while taking this medicine as it can increase drowsiness and other side effects. Keep this medicine out of reach of children and store it at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, particularly bradycardia, nausea, and dizziness. Close monitoring is recommended. Dose adjustments should be made cautiously.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect heart rate. Your doctor may advise you to stop the medicine temporarily before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth or affect heart rate, which could impact dental treatment. Your dentist may take precautions.

💚 Lifestyle Tips for Better Results

🏃
Maintain a regular routine to help with memory and orientation.
🥗
Engage in mentally stimulating activities like puzzles or reading.
😴
Stay physically active with low-impact exercises like walking or swimming.
💧
Ensure a balanced diet rich in fruits, vegetables, and omega-3 fatty acids.
🧘
Get adequate sleep and maintain a consistent sleep schedule.
🌞
Stay socially connected with family and friends.
🚭
Use memory aids like calendars, notes, and reminders.

🏋️ Exercise Considerations

This medicine may cause dizziness or fatigue. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Gentle exercises like walking or yoga are generally safe, but consult your doctor before starting any new exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods like fish, walnuts, and flaxseeds.
Eat plenty of fruits and vegetables.
Reduce intake of processed foods and refined sugars.
Stay well hydrated throughout the day.
Limit alcohol consumption.

💼 Impact on Daily Work & Life

This medicine may cause dizziness, drowsiness, or fatigue, which can affect your ability to drive or operate machinery. It is important to assess your alertness before performing such tasks. The medicine may also cause nausea or loss of appetite, which can impact your work performance. Discuss with your doctor if you experience side effects that interfere with your daily activities.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or if the medicine is no longer effective, your doctor may decide to discontinue it. Abrupt withdrawal may lead to worsening of symptoms. Your doctor will provide a tapering schedule if needed.

📅 Long-Term Use Effects

Long-term use of this medicine may continue to provide symptomatic benefits in Alzheimer's disease. However, its effectiveness may diminish over time as the disease progresses. Regular monitoring of cognitive function, cardiac status, and gastrointestinal symptoms is recommended. Some patients may experience weight loss with long-term use. Periodic reassessment by a clinician is necessary to determine if continued treatment is appropriate.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive stimulation therapy

Can complement medication to improve cognitive function and quality of life.

Evidence: Well-established
Physical exercise

Regular physical activity may help slow cognitive decline.

Evidence: Moderate
Mediterranean diet

A diet rich in fruits, vegetables, and healthy fats may support brain health.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific vaccine interactions reported with this medicine. However, consult your doctor before receiving any vaccinations while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. This is especially important for international travel, as customs may require documentation. Keep the medicine in your carry-on luggage to avoid loss or exposure to extreme temperatures. If you are crossing time zones, consult your doctor about how to adjust the timing of your doses. Store the medicine at room temperature and avoid leaving it in hot or humid places, such as a car glove compartment.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 72-year-old man with mild Alzheimer's disease
He started taking this medicine 5 mg at bedtime as prescribed. After about 6 weeks, his family noticed he was more engaged in conversations and could remember recent events better. He experienced mild nausea initially, which subsided after a few days. His doctor later increased the dose to 10 mg, and he continued to show gradual improvement.
💡 Lesson: This medicine can take several weeks to show effects, and side effects often diminish with continued use. Regular follow-up with the doctor is important to adjust the dose.
👤 A 68-year-old woman with moderate Alzheimer's disease
She was prescribed this medicine 5 mg daily. Her caregiver reported that she became less agitated and more cooperative with daily activities. However, she developed bradycardia, and her doctor reduced the dose back to 5 mg after monitoring her heart rate. She continued to benefit from the medication without further cardiac issues.
💡 Lesson: Monitoring for cardiac side effects is crucial, especially in elderly patients. Dose adjustments can help manage side effects while maintaining benefits.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: It may take several weeks to see improvement in symptoms. Full effects may take up to 12 weeks.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Q: Is this medicine safe for long-term use?

A: Yes, it is generally safe for long-term use under medical supervision. Regular monitoring is recommended.

Q: Can I stop taking this medicine suddenly?

A: No, do not stop taking this medicine without consulting your doctor. Abrupt discontinuation may worsen symptoms.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for donaz 5mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure Alzheimer's disease.
    Fact: This medicine does not cure Alzheimer's disease; it may help manage symptoms temporarily.
  • Myth: This medicine works immediately.
    Fact: It may take several weeks to see improvement.
  • Myth: This medicine is safe for everyone.
    Fact: It is not safe for people with certain heart conditions or allergies to donepezil.

🔄 Alternative Options

Generic Alternatives

  • Donepezil 5 mg tablet

Brand Alternatives

  • Aricep 5 Tablet
  • Donecept 5 Tablet
  • Donep 5 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Donepezil","class":"Acetylcholinesterase inhibitor","half_life":"70 hours","dosing":"Once daily"},{"medicine":"Galantamine","class":"Acetylcholinesterase inhibitor","half_life":"7 hours","dosing":"Twice daily"},{"medicine":"Rivastigmine","class":"Acetylcholinesterase inhibitor","half_life":"1.5 hours","dosing":"Twice daily"},{"medicine":"Memantine","class":"NMDA receptor antagonist","half_life":"60-80 hours","dosing":"Twice daily"}]

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