alsigra 25mg tablet

4.8 (14 reviews)

Sildenafil (25mg)

🏭 Alembic Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is alsigra 25mg tablet used for?

Assurans Tablet (Sildenafil) is used to treat SEX STIMULANTS REJUVENATORS. It contains Sildenafil (25mg), which Inhibits phosphodiesterase type 5 (PDE5), increasing cGMP levels in corpus caver. Always consult your doctor before use. Take as prescribed.

Generic Name: Sildenafil
Manufacturer: Alembic Pharmaceuticals Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 alsigra 25mg tablet Uses & Benefits

Treatment of erectile dysfunction; pulmonary arterial hypertension (as Revatio).

Off-label uses: Raynaud's phenomenon, altitude sickness, female sexual arousal disorder.

📋 Drug Information

Generic Name(s)	Sildenafil
Brand Name	Assurans Tablet
Manufacturer	Alembic Pharmaceuticals Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	SEX STIMULANTS REJUVENATORS
Action Class	Phosphodiesterase-V inhibitors
Route of Administration	Oral.
Storage	Store at 20-25°C (68-77°F); protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration, with absolute bioavailability of about 40%.

DistributionVolume of distribution approximately 105 L, distributed into tissues.

Protein BindingApproximately 96% bound to plasma proteins.

MetabolismPrimarily metabolized by CYP3A4 (major) and CYP2C9 (minor) to an active N-desmethyl metabolite.

Half-LifeApproximately 3-5 hours.

ExcretionPrimarily excreted in feces (80%) and urine (13%) as metabolites.

Bioavailability40% (oral).

Onset of Action30-60 minutes.

Peak Plasma Time30-120 minutes (median 60 minutes) under fasting conditions.

Duration of Action4-6 hours.

How It Works

Inhibits phosphodiesterase type 5 (PDE5), increasing cGMP levels in corpus cavernosum, leading to smooth muscle relaxation and increased blood flow.

Mechanism Steps

1Sexual stimulation releases nitric oxide (NO) in corpus cavernosum.

2NO activates guanylate cyclase, increasing cGMP synthesis.

3cGMP relaxes smooth muscle, increasing blood flow to penis.

💡 How to Take alsigra 25mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of alsigra 25mg tablet

✅ Common Side Effects

Headache
Flushing
Dyspepsia
Nasal congestion
Visual disturbances (blurred vision, blue tinge)

🚨 Serious Side Effects

Priapism (prolonged erection >4 hours)
Sudden hearing loss
Non-arteritic anterior ischemic optic neuropathy (NAION)
Hypotension

⚠️ Rare Side Effects

Seizures
Anaphylaxis
Stevens-Johnson syndrome
Prolonged QT interval

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Nitroglycerin	Major	Severe hypotension, syncope, myocardial infarction risk
Ritonavir	Moderate	Increased sildenafil exposure (AUC up to 11-fold)
Doxazosin	Moderate	Additive hypotensive effect
Grapefruit juice	Minor	Slight increase in sildenafil levels

🚨 Major Interactions

Nitrates (e.g., nitroglycerin, isosorbide mononitrate)
Nitric oxide donors (e.g., amyl nitrite)
Guanylate cyclase stimulators (e.g., riociguat)

⚡ Moderate Interactions

CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin)
CYP3A4 inducers (e.g., rifampin, phenytoin)
Alpha-blockers (e.g., doxazosin, tamsulosin)

ℹ️ Minor Interactions

Antacids (aluminum/magnesium hydroxide)
Grapefruit juice

🍽️ Food Interactions

High-fat meals delay absorption and reduce peak plasma concentration.

🍷 Alcohol Interaction

Alcohol may transiently impair erectile function; no direct pharmacokinetic interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Concurrent use of nitrates or nitric oxide donors; hypersensitivity; severe hepatic impairment; hypotension; recent stroke or MI; retinitis pigmentosa.

📊 Monitoring Parameters

Blood pressure, heart rate, visual symptoms, hearing loss.

🤱 Lactation Safety

Not recommended; excreted in breast milk in animal studies.

💊 Overdose Management

Supportive care; consider gastric lavage; monitor for hypotension; no specific antidote.

⏰ Missed Dose

Take as needed; do not take more than once daily.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for alsigra 25mg tablet

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Alternative brands with exact same active ingredient (Sildenafil (25mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.