Combither Forte 80mg/480mg Tablet: Complete Guide to Uses, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Fainting or loss of consciousness
- Irregular or very fast heartbeat
- Severe skin rash or blistering
- Yellowing of the eyes or skin
- Dark urine or decreased urine output
- Persistent vomiting preventing oral intake
- High fever not responding to treatment after 48 hours
If experiencing severe symptoms, call emergency services immediately.
What is alm 80 tablet used for?
This medicine is a combination antimalarial tablet containing artemether 80 mg and lumefantrine 480 mg. It is used to treat acute uncomplicated Plasmodium falciparum malaria in adults and children weighing 35 kg or more. It works by killing the malaria parasites in the blood. It must be taken with fatty food for best absorption.
- Generic Name: Artemether + Lumefantrine
- Manufacturer: Makers Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 alm 80 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा आर्टेमेथर और लुमेफैंट्रिन का संयोजन है, जिसका उपयोग मलेरिया (प्लास्मोडियम फाल्सीपेरम) के इलाज के लिए किया जाता है। यह मलेरिया परजीवी को मारती है और बुखार, ठंड लगना, पसीना आना, सिरदर्द और मांसपेशियों में दर्द जैसे लक्षणों से राहत दिलाती है। इसे भोजन के साथ लेना चाहिए ताकि यह अच्छी तरह से अवशोषित हो सके।
साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, चक्कर आना, मतली, उल्टी, पेट दर्द, धड़कन तेज होना और नींद में गड़बड़ी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, दिल की धड़कन में अनियमितता और लीवर की समस्या हो सकती है। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या बेहोशी महसूस हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें, और इसे भोजन या दूध के साथ लें। उपचार का पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। इलाज के दौरान शराब न पिएं। यदि आपको दिल, लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। दवा लेने के बाद चक्कर आ सकते हैं, इसलिए वाहन चलाने से बचें।
💊 alm 80 tablet Uses & Benefits
[{"condition":"Acute uncomplicated Plasmodium falciparum malaria","description":"First-line treatment for uncomplicated falciparum malaria in adults and children weighing 35 kg or more, as per WHO guidelines.","evidence":"Well-established"},{"condition":"Malaria in travelers returning from endemic areas","description":"Effective for treating uncomplicated falciparum malaria acquired in endemic regions.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Plasmodium vivax malaria","description":"Sometimes used in combination with primaquine for vivax malaria, but not the standard first-line treatment.","evidence":"Limited"}]
Primary treatment for: Acute uncomplicated Plasmodium falciparum malaria
Also treats: Malaria in travelers, Mixed malaria infections (with caution)
📋 Drug Information
| Generic Name(s) | Artemether + Lumefantrine |
| Brand Name | Artether L |
| Manufacturer | Makers Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in the original packaging, away from moisture and direct sunlight. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | WHO recommends artemether-lumefantrine as a first-line treatment for uncomplicated Plasmodium falciparum malaria in adults and children weighing 35 kg or more. |
| ICMR Guideline | ICMR guidelines also recommend artemether-lumefantrine as a first-line ACT for uncomplicated falciparum malaria in India. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimalarial agents with complementary mechanisms. Artemether, an artemisinin derivative, is activated by heme iron within the parasite's food vacuole, generating free radicals that alkylate and damage parasite proteins and membranes, leading to rapid parasite clearance. Lumefantrine, a aryl-amino alcohol, inhibits the formation of beta-hematin (hemozoin) in the food vacuole, preventing the detoxification of heme and causing toxic heme accumulation that kills the parasite. Together, they provide rapid symptom relief and prevent recrudescence.
Mechanism Steps
💡 How to Take alm 80 tablet
Strength: Tablet containing artemether 80 mg and lumefantrine 480 mg.
Dosage Information
| Adult Dosage | The standard adult dose for uncomplicated falciparum malaria is 4 tablets (each containing artemether 80 mg and lumefantrine 480 mg) taken orally at 0, 8, 24, 36, 48, and 60 hours. This medicine must be taken with fatty food or milk. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients, but use with caution due to potential cardiac and hepatic issues. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is required for mild to moderate renal impairment. Use with caution in severe renal impairment. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is required for mild to moderate hepatic impairment. Avoid in severe hepatic impairment. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is 4 tablets (artemether 320 mg and lumefantrine 1920 mg) per day, given as a split dose on the first day (0 and 8 hours). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of alm 80 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Amiodarone | Major | |
| Warfarin | Major | |
| Rifampicin | Moderate | |
| Carbamazepine | Moderate | |
| Phenytoin | Moderate | |
| Hormonal contraceptives | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
- Warfarin
⚡ Moderate Interactions
- CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- Hormonal contraceptives
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol may increase the risk of liver toxicity, dizziness, and gastrointestinal side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to artemether or lumefantrine","Severe malaria (requires parenteral therapy)","First trimester of pregnancy (unless no alternative)","Congenital long QT syndrome","Severe hepatic impairment","Severe renal impairment","Use with strong CYP3A4 inhibitors that prolong QT"]
⚠️ Warnings & Precautions
["Take with fatty food to ensure absorption.","Avoid in patients with known QT prolongation.","Monitor for signs of allergic reactions.","Use with caution in elderly and those with cardiac disease.","Do not use for malaria prevention.","Complete the full course to prevent resistance.","Avoid alcohol during treatment."]
🤱 Lactation Safety
Limited data. Artemether and lumefantrine are excreted in breast milk in small amounts. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
There is no specific antidote. Treatment is symptomatic and supportive. Monitor ECG for QT prolongation. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, with a fatty meal or a glass of milk to improve absorption. Do not skip doses or stop treatment early, even if you feel better, as this can lead to treatment failure and drug resistance. Avoid alcohol during treatment as it may increase the risk of liver problems and dizziness. Inform your doctor if you have heart, liver, or kidney disease, or if you are taking other medications, especially those that affect heart rhythm. This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. Store in the original packaging at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to cardiac side effects such as QT prolongation. Use with caution and monitor ECG if risk factors are present.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is generally avoided in the first trimester. Use effective contraception during treatment and for 1 month after.
🏥 Post-Surgery Considerations
No specific restrictions, but inform your surgeon and anesthesiologist about this medicine as it may interact with other drugs.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. No specific precautions are usually needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment as you may feel weak and dizzy. Gradually resume activities as you recover.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and fatigue. Avoid driving or operating heavy machinery until you know how it affects you. Take rest and stay hydrated.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full prescribed course even if you feel better. If you experience serious side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term effects are not well established as this medicine is typically used for short courses. However, repeated use may increase the risk of drug resistance. Monitoring for liver and heart function may be needed in patients with underlying conditions.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative first-line treatments for uncomplicated falciparum malaria.
Evidence: Well-establishedAlternative for treatment and prophylaxis.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. Ensure routine vaccinations are up to date.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If crossing time zones, adjust dosing times to maintain the 8-hour intervals as prescribed. Check customs regulations for carrying prescription medicines into your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within hours, but fever and other symptoms typically improve within 24-48 hours. Complete the full course for a cure.
A: No, this medicine must be taken with fatty food or milk to ensure proper absorption. Taking it without food may reduce its effectiveness.
A: If you vomit within 1 hour of taking a dose, consult your doctor as you may need to repeat the dose.
A: This medicine is generally considered safe in the second and third trimesters, but should be used only if clearly needed and under medical supervision. Avoid in the first trimester unless no alternative is available.
🤔 Common Patient Concerns
🔄 Substitutes for alm 80 tablet
View AllAlternative brands with exact same active ingredient:
-
Falcyrid 80 mg/480 mg TabletPrayas Pharmaceuticals ₹59.46 58.4% CHEAPER
-
lumex forte 80 mg/480 mg tabletLeo Life Science Pvt Ltd ₹64.28 55% CHEAPER
-
Thereco 80mg/480mg TabletReco Drugs ₹70.31 50.8% CHEAPER
-
macito-lf 80mg/480mg tabletUnikind Pharma ₹77.50 45.7% CHEAPER
-
Tartlum 80mg/480mg TabletTusker Pharma Pvt Ltd ₹82.01 42.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used to prevent malaria.
Fact: This medicine is only for treating confirmed malaria, not for prevention. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course to prevent relapse and resistance. - Myth: This medicine works for all types of malaria.
Fact: It is specifically for Plasmodium falciparum malaria and not for other species like vivax.
🔄 Alternative Options
Generic Alternatives
- Artemether 80 mg + Lumefantrine 480 mg tablet (generic)
Brand Alternatives
- Coartem 80/480
- Lumether Forte
- Falcigo 80/480