alight plus gel - Adapalene (0.1% w/w) + Clindamycin (1% w/w) medicine

alight plus gel

No reviews yet
🏭 Leeford Healthcare Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is alight plus gel used for?

This medicine contains Adapalene (0.1% w/w) + Clindamycin (1% w/w) and is used to treat DERMA. Adapalene binds to retinoic acid receptors (RARs) to normalize follicular keratinization; Clindamyci. Always consult your doctor before use.

  • Generic Name: Adapalene + Clindamycin
  • Manufacturer: Leeford Healthcare Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 alight plus gel Uses & Benefits

Acne vulgaris (inflammatory and non-inflammatory lesions)

Off-label uses: Keratosis pilaris, Photodamage, Melasma

📋 Drug Information

Generic Name(s)Adapalene + Clindamycin
Brand NameAcnesol A Nano Gel
ManufacturerLeeford Healthcare Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassRetinoid + Antibiotic
Route of AdministrationTopical
StorageStore at 20-25°C (68-77°F); protect from light and heat
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMinimal systemic absorption; primarily local cutaneous absorption
DistributionNot extensively studied; limited systemic distribution
Protein BindingAdapalene: >95% bound to plasma proteins; Clindamycin: ~60-94% bound
MetabolismAdapalene: Hepatic via CYP2C9 and CYP3A4; Clindamycin: Hepatic via CYP3A4
Half-LifeAdapalene: ~7-12 hours; Clindamycin: ~2-3 hours
ExcretionAdapalene: Biliary; Clindamycin: Renal and biliary
BioavailabilityLow systemic bioavailability due to topical application
Onset of Action2-4 weeks
Peak Plasma TimeNot applicable for topical use
Duration of ActionNot specified; applied once daily

How It Works

Adapalene binds to retinoic acid receptors (RARs) to normalize follicular keratinization; Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal subunit

Mechanism Steps

1Adapalene binds to RAR-β and RAR-γ receptors in keratinocytes
2Modulates gene expression to normalize follicular keratinization
3Reduces microcomedone formation and comedogenesis
4Clindamycin penetrates bacterial cell wall
5Binds to 50S ribosomal subunit
6Inhibits peptide bond formation and protein synthesis
7Exerts bacteriostatic effect against Propionibacterium acnes
8Reduces bacterial load and inflammation

💡 How to Take alight plus gel

Follow your doctor's prescription exactly.

⚠️ Side Effects of alight plus gel

✅ Common Side Effects

Skin dryness
Erythema
Peeling
Burning
Stinging
Pruritus

🚨 Serious Side Effects

Pseudomembranous colitis
Severe allergic reactions
Photosensitivity

⚠️ Rare Side Effects

Contact dermatitis
Hyperpigmentation
Hypopigmentation

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Erythromycin Major Antagonism of clindamycin antibacterial effect
Tetracyclines Major Increased risk of pseudomembranous colitis
Systemic retinoids Major Increased risk of hypervitaminosis A
Neuromuscular blocking agents Major Enhanced neuromuscular blockade
Topical corticosteroids Moderate May reduce efficacy of adapalene
Topical benzoyl peroxide Moderate May cause skin irritation; use with caution
Other topical antibiotics Moderate Possible cross-resistance or irritation

🚨 Major Interactions

  • Erythromycin
  • Tetracyclines
  • Systemic retinoids
  • Neuromuscular blocking agents

⚡ Moderate Interactions

  • Topical corticosteroids
  • Topical benzoyl peroxide
  • Other topical antibiotics

🍷 Alcohol Interaction

No known interaction

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to adapalene, clindamycin, or any component; history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis

🤱 Lactation Safety

Caution; not recommended during breastfeeding

💊 Overdose Management

Excessive topical application may cause severe irritation; treat symptomatically; accidental ingestion may cause gastrointestinal effects; supportive care

⏰ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose; do not double dose

🔄 Substitutes for alight plus gel

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory