acreva ms 0.1% cream - Adapalene (0.1% w/w) medicine

Acreva MS 0.1% Cream - Uses, Price, Side Effects

4.4 (14 reviews)

Adapalene (0.1% w/w)

🏭 Zee Laboratories 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is acreva ms 0.1% cream used for?

Acreva MS 0.1% Cream contains Adapalene, a retinoid that treats acne by regulating skin cell turnover and reducing inflammation. It is applied once daily at night to clean, dry skin. Common side effects include dryness, redness, and peeling. It is for external use only.

Generic Name: Adapalene
Manufacturer: Zee Laboratories
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 acreva ms 0.1% cream Uses & Benefits

Acne vulgaris (comedonal, inflammatory, and mixed acne).

Off-label uses: Photoaging, Keratosis pilaris, Melasma

📋 Drug Information

Generic Name(s)	Adapalene
Brand Name	Adaferin Gel
Manufacturer	Zee Laboratories
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Retinoids- Third generation
Route of Administration	Topical
Storage	Store at 20-25°C (68-77°F); protect from light and heat.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionApproximately 2.5% of topically applied adapalene is absorbed through the skin.

DistributionDistributed into skin layers; systemic distribution is minimal due to low absorption.

Protein Binding>99% bound to plasma proteins.

MetabolismMetabolized primarily by cytochrome P450 enzymes, mainly CYP2C9 and CYP3A4.

Half-LifeApproximately 7-10 hours (topical); systemic half-life not well defined.

ExcretionPrimarily excreted in feces (biliary) and to a lesser extent in urine.

BioavailabilityLow systemic bioavailability (<5%) due to minimal percutaneous absorption.

Onset of ActionClinical improvement may be seen within 2-4 weeks of regular use.

Peak Plasma TimeNot applicable for topical use; systemic levels are negligible.

Duration of ActionSustained effect with once-daily application; continuous use required for maintenance.

How It Works

Binds to retinoic acid receptors (RARs), modulating gene expression to normalize follicular keratinization and reduce inflammation.

Mechanism Steps

1Binds to retinoic acid receptors (RAR-β and RAR-γ) in keratinocytes

2Modulates gene expression involved in cell differentiation and proliferation

3Normalizes follicular keratinization, reducing microcomedone formation

💡 How to Take acreva ms 0.1% cream

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of acreva ms 0.1% cream

✅ Common Side Effects

Skin dryness
Erythema
Peeling
Burning sensation
Pruritus

🚨 Serious Side Effects

Severe allergic reaction
Angioedema
Stevens-Johnson syndrome (rare)

⚠️ Rare Side Effects

Hyperpigmentation
Hypopigmentation
Photosensitivity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Benzoyl Peroxide	Moderate	May cause skin irritation if used together
Sulfur	Minor	Increased skin dryness
Salicylic Acid	Moderate	Enhanced skin peeling

🚨 Major Interactions

Other topical retinoids
Benzoyl peroxide (concomitant use may cause irritation)

⚡ Moderate Interactions

Topical corticosteroids
Topical antibiotics (e.g., clindamycin)

ℹ️ Minor Interactions

Sunscreens
Cosmetics with drying agents

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction; however, alcohol may increase skin dryness.

🛡️ Safety & Warnings

Liver

Low

Kidney

Low

Heart

Low

Pregnancy

Category C

🚫 Contraindications

Hypersensitivity to adapalene or any component; pregnancy (category C); eczema; sunburn.

📊 Monitoring Parameters

Skin irritation, dryness, peeling; therapeutic response (reduction in acne lesions).

🤱 Lactation Safety

Not recommended; unknown if excreted in breast milk.

💊 Overdose Management

Topical overdose unlikely; if ingested, treat symptomatically.

⏰ Missed Dose

Apply as soon as remembered; if close to next dose, skip missed dose. Do not double.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for acreva ms 0.1% cream

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Alternative brands with exact same active ingredient (Adapalene (0.1% w/w)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.