zathrin gel - Adapalene (0.1% w/w) + Clindamycin (1% w/w) medicine

Adamycin Gel: Complete Guide to Uses, Side Effects, and Safety

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🏭 FDC Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
🤰 Pregnancy Category Adapalene: FDA pregnancy category C. Clindamycin: FDA pregnancy category B. However, topical use has minimal systemic absorption. Consult your doctor before use. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for acne vulgaris.
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction: swelling of face, lips, throat, difficulty breathing.
  • Severe diarrhea, abdominal cramps, or blood in stool.
  • Severe skin blistering, peeling, or swelling.
  • Signs of infection: pus, fever, increased pain.
  • No improvement after 12 weeks of consistent use.
  • Sudden worsening of acne with severe redness and pain.

If experiencing severe symptoms, call emergency services immediately.

What is zathrin gel used for?

This medicine is a topical gel containing adapalene 0.1% and clindamycin 1%, used to treat acne vulgaris. It works by unclogging pores and reducing acne-causing bacteria. Apply a thin layer once daily in the evening.

  • Generic Name: Adapalene (0.1% w/w) + Clindamycin (1% w/w)
  • Manufacturer: FDC Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 zathrin gel के बारे में (Hindi Summary)

उपयोग: यह दवा मुँहासे (एक्ने) के इलाज के लिए एक टॉपिकल जेल है। इसमें एडापेलीन और क्लिंडामाइसिन दो सक्रिय तत्व हैं। यह मुँहासे, ब्लैकहेड्स और व्हाइटहेड्स को कम करने में मदद करती है। यह त्वचा के छिद्रों को खोलती है और मुँहासे पैदा करने वाले बैक्टीरिया को कम करती है। इसे रात में एक बार पतली परत में लगाएं।

साइड इफेक्ट्स: आम दुष्प्रभावों में त्वचा का सूखना, छीलना, लालिमा, जलन और खुजली शामिल हैं। ये आमतौर पर हल्के होते हैं और उपयोग जारी रखने पर कम हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन गंभीर एलर्जी प्रतिक्रिया या लगातार दस्त हो सकते हैं। यदि ऐसा हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: केवल बाहरी उपयोग के लिए। आँखों, होंठों और श्लेष्मा झिल्ली से बचें। साफ और सूखी त्वचा पर पतली परत लगाएं। उपयोग से पहले और बाद में हाथ धोएं। धूप से बचें और सनस्क्रीन का उपयोग करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 zathrin gel Uses & Benefits

[{"condition":"Acne vulgaris","description":"Reduces both inflammatory and non-inflammatory acne lesions by combining comedolytic and antibacterial actions.","evidence":"Well-established"}]

Off-label uses: []

Primary treatment for: Acne vulgaris

📋 Drug Information

Generic Name(s)Adapalene (0.1% w/w) + Clindamycin (1% w/w)
Brand Namezathrin gel
ManufacturerFDC Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action Class
Route of AdministrationTopical
StorageStore at room temperature (15-30°C). Protect from light and moisture. Keep the tube tightly closed when not in use.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply a thin layer only; using more can cause irritation without faster results.
2
Use a pea-sized amount for the entire face if treating widespread acne.
3
Wait 20-30 minutes after washing your face before applying to reduce stinging.
4
Use a non-comedogenic moisturizer to manage dryness.
5
Apply sunscreen every morning, as adapalene increases sun sensitivity.
6
Avoid using other irritating skincare products like scrubs or astringents.
7
Be patient; it may take 8-12 weeks to see full improvement.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Acne (pimples, blackheads, whiteheads)
This medicine is commonly prescribed for this.
Likely Use
❌
Skin dryness
This medicine may cause dryness as a side effect.
Not Primary
❌
Severe diarrhea
This is a potential serious side effect; seek medical attention.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAdapalene: minimal percutaneous absorption after topical application; systemic levels are very low. Clindamycin: after topical application, clindamycin can be absorbed through the skin, but systemic absorption is generally low (approximately 1-5% of a dose).
DistributionNot established from the available information.
Protein BindingAdapalene: >99% bound to plasma proteins. Clindamycin: approximately 90% bound to plasma proteins.
MetabolismAdapalene: metabolized primarily in the liver via cytochrome P450 enzymes. Clindamycin: metabolized in the liver to active and inactive metabolites.
Half-LifeAdapalene: terminal half-life approximately 7-12 hours after oral administration; topical data not established. Clindamycin: half-life approximately 2-3 hours.
ExcretionAdapalene: primarily excreted in bile and feces. Clindamycin: excreted in urine and bile.
BioavailabilityNot established from the available information for the topical gel.
Onset of ActionInitial improvement may be seen within 2-4 weeks, but maximum benefit may take 8-12 weeks of regular use.
Peak Plasma TimeNot established from the available information for topical use.
Duration of ActionNot established from the available information.

How It Works

Adapalene is a third-generation topical retinoid that modulates cell differentiation, keratinization, and inflammatory processes. It binds selectively to retinoic acid receptors (RAR-beta and RAR-gamma) in the skin, leading to normalization of follicular keratinization and decreased formation of microcomedones. Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby reducing the population of Cutibacterium acnes (formerly Propionibacterium acnes) on the skin. The combination provides complementary mechanisms: adapalene addresses comedogenesis and inflammation, while clindamycin targets bacterial colonization.

Mechanism Steps

1
Adapalene binding to RAR: Adapalene binds selectively to retinoic acid receptors in the skin, modulating gene expression.
2
Normalization of keratinization: This leads to reduced microcomedone formation and unclogging of pores.
3
Clindamycin inhibition of bacterial protein synthesis: Clindamycin binds to the 50S ribosomal subunit of Cutibacterium acnes, inhibiting protein synthesis and reducing bacterial load.
4
Reduction of inflammation: Both agents contribute to decreased inflammatory mediators in the skin, leading to fewer red, swollen pimples.

💡 How to Take zathrin gel

Strength: Gel containing adapalene 0.1% w/w and clindamycin 1% w/w.

1Wash your hands before application.
2Cleanse the affected area with a mild cleanser and pat dry.
3Apply a thin layer of the gel to the affected area, avoiding eyes, lips, and mucous membranes.
4Wash your hands after application.
5Use once daily in the evening unless directed otherwise by your doctor.

Dosage Information

Adult DosageApply a thin layer of this medicine to the affected areas once daily in the evening, after washing and drying the skin. Avoid applying to unaffected areas. The dose and duration must be individualized by a qualified clinician based on the severity of acne and response to treatment. Do not use more than prescribed.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dosage adjustments are required for elderly patients. However, consult a doctor before use.
Renal ImpairmentNo dosage adjustment is required for renal impairment when used topically, as systemic absorption is minimal.
Hepatic ImpairmentNo dosage adjustment is required for hepatic impairment when used topically, as systemic absorption is minimal.
Maximum Daily DoseApply once daily. Do not exceed the recommended frequency.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Apply the missed dose as soon as you remember.
💡 Continue with your regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not apply a double dose.

⚠️ Side Effects of zathrin gel

✅ Common Side Effects

Dry skin (Common (10-30%))
Apply a moisturizer if needed. If dryness persists, consult your doctor.
Peeling (Common (10-30%))
Avoid using other irritating products. Consult doctor if severe.
Redness (Common (10-30%))
Usually subsides with continued use. If it worsens, stop and consult doctor.
Burning or stinging (Common (5-15%))
Apply a gentle moisturizer. If severe, discontinue and consult doctor.
Itching (Common (5-15%))
Avoid scratching. Consult doctor if persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, throat, or difficulty breathing.
Antibiotic-associated colitis (Rare (<0.1%))
Seek immediate medical attention if you develop severe or persistent diarrhea, abdominal cramps, or blood in stool.
Severe skin irritation or dermatitis (Uncommon (0.1-1%))
Discontinue use and consult a doctor if you experience severe redness, blistering, or swelling.

⚠️ Rare Side Effects

Photosensitivity reaction
Use sunscreen and avoid sun exposure. Consult doctor if reaction occurs.
Skin discoloration
Usually reversible. Consult doctor if concerned.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Tretinoin Major
Erythromycin (topical) Major
Neuromuscular blockers Moderate
Kaolin-pectin Moderate
Benzoyl peroxide Minor

🚨 Major Interactions

  • Other topical retinoids (e.g., tretinoin, tazarotene)
  • Topical antibiotics (e.g., erythromycin)

⚡ Moderate Interactions

  • Neuromuscular blocking agents
  • Kaolin-pectin antidiarrheal

🍷 Alcohol Interaction

No known interaction between this topical gel and alcohol. However, alcohol consumption may worsen acne and should be limited.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to adapalene, clindamycin, or any component of the gel","Use on broken or eczematous skin","Use in patients with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis"]

⚠️ Warnings & Precautions

["For external use only. Avoid contact with eyes, lips, and mucous membranes.","Do not apply to cuts, abrasions, or irritated skin.","Avoid excessive sun exposure and use sunscreen.","Discontinue if severe irritation or allergic reaction occurs.","Consult doctor before use if pregnant, planning pregnancy, or breastfeeding.","Keep out of reach of children.","Do not use for prolonged periods without medical supervision."]

🤱 Lactation Safety

It is not known whether adapalene or clindamycin is excreted in human milk after topical application. Because many drugs are excreted in human milk, caution should be exercised when this medicine is used by a nursing woman. Consult your doctor.

💊 Overdose Management

This medicine is for topical use. Accidental ingestion may cause systemic effects. If ingested, seek medical attention immediately. Overapplication on the skin may cause severe irritation; wash off with water and consult a doctor if symptoms persist.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Additional Safety Advice

General Safety

For external use only. Avoid contact with eyes, lips, and mucous membranes. If accidental contact occurs, rinse thoroughly with water. Apply a thin layer to clean, dry skin. Wash your hands before and after application. Do not cover the treated area with tight dressings or bandages unless directed by a doctor. Use sunscreen daily and avoid excessive sun exposure, as adapalene can increase sun sensitivity. Do not use other topical acne products unless advised by your doctor. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children. Do not use after the expiry date.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Acne is less common in the elderly, but if prescribed, use with caution. Monitor for skin irritation and consult a doctor regularly.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before using this medicine. Topical adapalene and clindamycin have low systemic absorption, but the safety profile is not fully established. Your doctor may recommend alternative treatments.

🏥 Post-Surgery Considerations

If you have recently had surgery, consult your doctor before using this medicine on the affected area. Avoid applying to surgical wounds.

🦷 Dental Procedures

No specific precautions for dental procedures. Inform your dentist about all medicines you are using.

💚 Lifestyle Tips for Better Results

🏃
Cleanse your face gently twice daily with a mild cleanser.
🥗
Avoid picking or squeezing pimples to prevent scarring.
😴
Use a non-comedogenic moisturizer to manage dryness.
💧
Apply sunscreen daily to protect against sun sensitivity.
🧘
Maintain a healthy diet and stay hydrated.
🌞
Manage stress, as it can worsen acne.

🏋️ Exercise Considerations

Exercise is generally safe while using this medicine. However, sweat may irritate the skin, so wash your face gently after exercising. Avoid sharing towels or equipment that may come into contact with treated areas.

🥗 Diet Recommendations

Include fruits and vegetables rich in antioxidants.
Reduce intake of high-glycemic foods and dairy if they worsen your acne.
Stay well hydrated.
Limit processed and sugary foods.

💼 Impact on Daily Work & Life

This medicine does not affect your ability to drive or operate machinery. It may cause mild skin irritation, but this should not impact your daily activities. If you experience severe irritation, consult your doctor.

🛑 When to Stop This Medicine

Do not stop using this medicine without consulting your doctor. If you experience severe side effects, discontinue use and seek medical advice. Your doctor may adjust the treatment or recommend an alternative.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe. However, prolonged use of topical antibiotics like clindamycin may lead to bacterial resistance. Regular follow-up with your doctor is recommended to assess continued need. If used for extended periods, monitor for any signs of irritation or secondary infections.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Oral antibiotics

For moderate to severe acne, oral antibiotics like doxycycline may be prescribed.

Evidence: Well-established
Chemical peels

Professional chemical peels can complement topical treatments.

Evidence: Moderate
Laser therapy

May be used for resistant acne or scarring.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. Continue routine vaccinations as scheduled.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from extreme heat or cold. When flying, keep it in your carry-on luggage. If crossing time zones, continue applying once daily in the evening local time. Customs may require documentation for prescription medicines, so keep your prescription handy.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 22-year-old college student with moderate acne
She started using this medicine as prescribed every night. After 4 weeks, she noticed fewer pimples and less oiliness. She experienced mild dryness, which was managed with a moisturizer. By 10 weeks, her skin was significantly clearer.
💡 Lesson: Consistent use and proper skincare (moisturizer and sunscreen) are key to success.
👤 A 30-year-old professional with persistent acne
He had tried many over-the-counter products without success. His dermatologist prescribed this medicine. He applied it every evening and avoided picking at his skin. After 3 months, his acne was well-controlled, and he continued as maintenance therapy twice a week.
💡 Lesson: Prescription treatment and patience can lead to significant improvement even in stubborn acne.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start seeing improvement in 2-4 weeks, but full benefits may take 8-12 weeks of consistent use.

Q: Can I use this medicine with other acne treatments?

A: Consult your doctor before combining with other acne treatments, as it may increase irritation.

Q: Is this medicine safe during pregnancy?

A: Consult your doctor. Topical adapalene and clindamycin have low systemic absorption, but safety is not fully established.

Q: What should I do if I miss a dose?

A: Apply it as soon as you remember if less than 12 hours have passed. Otherwise, skip and continue with your regular schedule.

Q: Can I apply makeup over this medicine?

A: Yes, but wait until the gel has dried completely. Use non-comedogenic makeup.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine long-term?
  • Will it make my skin sensitive to the sun?
  • Can I apply makeup over this medicine?
  • Does it interact with my other skincare products?
  • What if I miss a dose?
  • Can I use it during pregnancy?

🔄 Substitutes for zathrin gel

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine works overnight.
    Fact: It may take several weeks to see improvement.
  • Myth: More application means faster results.
    Fact: Applying more than a thin layer can cause severe irritation without added benefit.
  • Myth: You can stop using it once acne clears.
    Fact: Acne may recur; maintenance therapy may be needed as advised by your doctor.

🔄 Alternative Options

Generic Alternatives

  • Adapalene 0.1% + Clindamycin 1% gel (generic)

📊 Comparison with Similar Medicines

[{"medicine":"Adapalene 0.1% + Clindamycin 1% gel","active_ingredients":"Adapalene, Clindamycin","primary_use":"Acne vulgaris","route":"Topical"},{"medicine":"Adapalene 0.1% gel","active_ingredients":"Adapalene","primary_use":"Acne vulgaris","route":"Topical"},{"medicine":"Clindamycin 1% gel","active_ingredients":"Clindamycin","primary_use":"Acne vulgaris","route":"Topical"}]

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