What is agra 50mg tablet used for?

This medicine is a prescription tablet containing sildenafil 50 mg, used to treat erectile dysfunction in men. It works by increasing blood flow to the penis during sexual stimulation. It should not be taken with nitrates.

Generic Name: Sildenafil
Manufacturer: Alliaance Biotech
Form: Allopathy
Pregnancy Category: Consult doctor
Prescription Required: Yes

🇮🇳 agra 50mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा सिल्डेनाफिल 50 मिलीग्राम की एक प्रिस्क्रिप्शन टैबलेट है, जिसका उपयोग पुरुषों में स्तंभन दोष (इरेक्टाइल डिसफंक्शन) के इलाज के लिए किया जाता है। यह दवा यौन उत्तेजना के दौरान लिंग में रक्त के प्रवाह को बढ़ाकर काम करती है, जिससे इरेक्शन प्राप्त करने और बनाए रखने में मदद मिलती है। यह दवा अपने आप इरेक्शन नहीं करती है और इसे यौन उत्तेजना की आवश्यकता होती है। यह दवा उन पुरुषों के लिए नहीं है जो नाइट्रेट या रियोसिगुआट का उपयोग करते हैं, क्योंकि इससे रक्तचाप में खतरनाक गिरावट हो सकती है। इस दवा का उपयोग केवल डॉक्टर के पर्चे के साथ ही करना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चेहरे पर लालिमा, नाक बंद होना, अपच और चक्कर आना शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें प्रियापिज्म (4 घंटे से अधिक समय तक इरेक्शन), अचानक दृष्टि हानि, अचानक सुनने की हानि और गंभीर निम्न रक्तचाप शामिल हो सकते हैं। यदि इनमें से कोई भी लक्षण दिखे तो तुरंत चिकित्सा सहायता लें।

सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। एक दिन में एक से अधिक खुराक न लें। शराब से बचें, क्योंकि इससे निम्न रक्तचाप का खतरा बढ़ सकता है और दवा का प्रभाव कम हो सकता है। नाइट्रेट, रियोसिगुआट या अल्फा-ब्लॉकर्स के साथ इस दवा को बिना डॉक्टर की सलाह के न लें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। यदि सीने में दर्द हो तो यौन गतिविधि रोकें और तुरंत आपातकालीन सहायता लें।

💊 agra 50mg tablet Uses & Benefits

[{"condition":"Erectile Dysfunction","description":"This medicine is used to treat erectile dysfunction in adult men by improving blood flow to the penis during sexual stimulation.","evidence":"Well-established"},{"condition":"Pulmonary Arterial Hypertension","description":"Sildenafil is also used to treat pulmonary arterial hypertension, but this 50 mg immediate-release tablet is not the standard formulation for that indication.","evidence":"Well-established for specific formulations"}]

Off-label uses: [{"condition":"Raynaud's Phenomenon","description":"Sometimes prescribed off-label to improve blood flow in Raynaud's phenomenon.","evidence":"Limited"},{"condition":"High Altitude Pulmonary Edema","description":"Occasionally used off-label for prevention of high altitude pulmonary edema.","evidence":"Limited"}]

Primary treatment for: Erectile Dysfunction

Also treats: Pulmonary Arterial Hypertension

📋 Drug Information

Generic Name(s)	Sildenafil
Brand Name	Assurans Tablet
Manufacturer	Alliaance Biotech
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	SEX STIMULANTS REJUVENATORS
Action Class	Phosphodiesterase-V inhibitors
Route of Administration	Oral
Storage	Store at room temperature (15-30°C) away from moisture and direct sunlight. Keep out of reach of children.
Shelf Life	24 months from the date of manufacture.
WHO Guideline	Not established from the available information.
ICMR Guideline	Not established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1

Take this medicine about 1 hour before sexual activity for best results.

2

Avoid taking this medicine with a high-fat meal as it may delay the onset of action.

3

Do not take this medicine if you are using nitrates or riociguat.

4

Limit alcohol consumption as it can increase the risk of dizziness and low blood pressure.

5

If you experience an erection lasting more than 4 hours, seek immediate medical help.

6

Inform your doctor about all other medications you are taking, especially for blood pressure or fungal infections.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅

Erectile dysfunction

This medicine is commonly prescribed for this condition.

Likely Use

❌

Pulmonary arterial hypertension

This formulation is not typically used for this; other formulations are available.

Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed after oral administration. The absolute bioavailability is approximately 40%. Food does not significantly affect the extent of absorption, but a high-fat meal may delay the onset of action.

DistributionThis medicine is widely distributed in the body. The volume of distribution is approximately 105 liters. It is about 96% bound to plasma proteins.

Protein BindingApproximately 96% bound to plasma proteins.

MetabolismThis medicine is primarily metabolized in the liver by the cytochrome P450 enzymes CYP3A4 and CYP2C9. Its main metabolite is N-desmethyl sildenafil, which has about 50% of the potency of the parent drug.

Half-LifeThe elimination half-life is approximately 4 hours.

ExcretionThis medicine is excreted mainly in the feces (about 80%) and urine (about 13%) as metabolites.

BioavailabilityApproximately 40%

Onset of ActionUsually within 30 to 60 minutes after oral administration.

Peak Plasma Time30 to 120 minutes (median 60 minutes) in the fasted state.

Duration of ActionThe effect typically lasts for about 4 hours, but can be longer in some individuals.

How It Works

This medicine works by selectively inhibiting the phosphodiesterase type 5 (PDE5) enzyme. This enzyme is responsible for breaking down cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. When cGMP levels increase, the smooth muscle relaxes, allowing more blood to flow into the penis, which leads to an erection. This medicine requires sexual stimulation to release nitric oxide, which initiates the cascade.

Mechanism Steps

1

Sexual stimulation: Sexual arousal causes the release of nitric oxide (NO) in the corpus cavernosum.

2

cGMP production: Nitric oxide activates guanylate cyclase, which increases the production of cyclic guanosine monophosphate (cGMP).

3

PDE5 inhibition: This medicine inhibits the PDE5 enzyme, preventing the breakdown of cGMP.

4

Smooth muscle relaxation: Elevated cGMP levels cause relaxation of smooth muscle in the penile arteries, leading to increased blood flow and erection.

💡 How to Take agra 50mg tablet

Strength: 50 mg immediate-release tablet

1Take this medicine orally with a glass of water.

2Take it about 1 hour before sexual activity.

3Do not take more than one dose in 24 hours.

4Avoid taking with a high-fat meal as it may delay the effect.

5Do not take with nitrates or riociguat.

Dosage Information

Adult Dosage	The recommended dose for erectile dysfunction is 50 mg taken orally about 1 hour before sexual activity. The dose may be adjusted to 25 mg or 100 mg based on efficacy and tolerability. Do not take more than once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric Dosage	Pediatric dosing is not established from available information. Consult a pediatrician.
Elderly Dosage	In elderly patients (above 65 years), the starting dose should be 25 mg due to reduced clearance. Dose must be individualized by a qualified clinician.
Renal Impairment	No dose adjustment is needed for mild to moderate renal impairment. In severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 25 mg is recommended. Dose must be individualized by a qualified clinician.
Hepatic Impairment	In patients with hepatic impairment (Child-Pugh A and B), a starting dose of 25 mg is recommended. This medicine is contraindicated in severe hepatic impairment. Dose must be individualized by a qualified clinician.
Maximum Daily Dose	100 mg per day.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

High-fat meal

Avoid taking immediately after

May delay the onset of action.

Grapefruit juice

Avoid large amounts

May increase sildenafil levels.

⏰ What to Do If You Miss a Dose

📌 This medicine is taken as needed

→ If you miss a dose, take it when you remember before sexual activity.

💡 Do not take more than one dose in 24 hours.

⚠️ Side Effects of agra 50mg tablet

✅ Common Side Effects

Headache (Common (10-20%))

Usually resolves on its own. If persistent or severe, consult your doctor.

Flushing (Common (10-20%))

Usually temporary. Avoid alcohol to reduce flushing.

Nasal congestion (Common (5-10%))

Usually resolves without treatment. Consult doctor if bothersome.

Indigestion (Common (5-10%))

Take with food if it upsets your stomach. Consult doctor if persistent.

Dizziness (Common (2-5%))

Avoid driving or operating machinery if you feel dizzy.

🚨 Serious Side Effects

Priapism (prolonged erection) (Rare (<0.1%))

Seek immediate medical attention if erection lasts more than 4 hours.

Sudden vision loss (Rare (<0.1%))

Stop taking this medicine and seek emergency care immediately.

Sudden hearing loss (Rare (<0.1%))

Stop taking this medicine and consult your doctor promptly.

Severe hypotension (Rare (<0.1%))

Seek emergency help if you experience fainting, chest pain, or severe dizziness.

⚠️ Rare Side Effects

Seizures

Seek immediate medical attention.

Anxiety

Consult your doctor if it persists.

Epistaxis

Usually self-limiting. Consult doctor if recurrent.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
Nitrates	Major
Riociguat	Major
Alpha-blockers	Major
CYP3A4 inhibitors	Major
CYP3A4 inducers	Moderate
Alcohol	Moderate
Grapefruit juice	Moderate
Antacids	Minor
H2 blockers	Minor

🚨 Major Interactions

Nitrates (e.g., nitroglycerin, isosorbide mononitrate)
Riociguat
Alpha-blockers (e.g., doxazosin, terazosin)
CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)

⚡ Moderate Interactions

CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
Grapefruit juice
Alcohol

🍷 Alcohol Interaction

Alcohol can increase the risk of low blood pressure, dizziness, and can reduce the ability to get an erection. It is advisable to limit or avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Concomitant use of nitrates","Concomitant use of riociguat","Severe cardiovascular disease where sexual activity is inadvisable","Recent stroke or myocardial infarction","Severe hypotension","Known hypersensitivity to sildenafil"]

⚠️ Warnings & Precautions

["This medicine should be used with caution in patients with anatomical deformation of the penis or conditions predisposing to priapism.","Patients with bleeding disorders or active peptic ulcers should use this medicine with caution.","This medicine may cause a sudden decrease in blood pressure, especially in patients taking alpha-blockers.","This medicine should not be used in patients with hereditary degenerative retinal disorders.","This medicine may impair the ability to drive or operate machinery if dizziness occurs."]

🤱 Lactation Safety

Not applicable. This medicine is not indicated for use in women.

💊 Overdose Management

Overdose of this medicine may cause severe hypotension, syncope, and priapism. Treatment should be supportive and symptomatic. Dialysis is not expected to be helpful because sildenafil is highly protein-bound.

⏰ Missed Dose

This medicine is taken on an as-needed basis, so a missed dose is not applicable. Do not take more than one dose per day.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not take more than one dose per day. Avoid alcohol, as it can increase the risk of low blood pressure and reduce the effectiveness of this medicine. Do not take this medicine with nitrates, riociguat, or alpha-blockers without consulting your doctor. Inform your doctor about all other medicines you are taking, especially for blood pressure, HIV, or fungal infections. If you experience chest pain, stop sexual activity and seek emergency help. Do not share this medicine with others.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine. A lower starting dose of 25 mg is recommended. Monitor blood pressure closely.

🤰 Pregnancy Planning (TTC)

This medicine is not indicated for use in women. If you are planning pregnancy, consult your doctor for appropriate advice.

🏥 Post-Surgery Considerations

Consult your doctor before resuming this medicine after surgery, especially if you have undergone cardiovascular or urological procedures.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with certain medications used during dental procedures. No specific precautions are usually needed.

💚 Lifestyle Tips for Better Results

🏃

Maintain a healthy weight to improve overall cardiovascular health.

🥗

Exercise regularly to improve blood flow and erectile function.

😴

Reduce stress through relaxation techniques like meditation or yoga.

💧

Avoid smoking, as it can worsen erectile dysfunction.

🧘

Get adequate sleep to support hormonal balance.

🏋️ Exercise Considerations

Avoid strenuous exercise immediately after taking this medicine if you experience dizziness or low blood pressure. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include fruits and vegetables rich in antioxidants.

Reduce intake of processed and high-fat foods.

Stay well hydrated.

Limit alcohol and caffeine.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or vision changes in some individuals. Avoid driving or operating heavy machinery if you experience these effects. It does not affect your ability to work otherwise.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects, seek immediate medical attention. Your doctor may adjust the dose or switch to an alternative.

📅 Long-Term Use Effects

Long-term use of this medicine is generally well-tolerated. However, regular monitoring of blood pressure and cardiovascular health is advised. There is no evidence of tolerance or dependence with long-term use. Consult your doctor for periodic evaluation.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Weight loss, exercise, and stress reduction can improve erectile function.

Evidence: Well-established

Psychotherapy

Counseling can help if psychological factors contribute to erectile dysfunction.

Evidence: Well-established

Vacuum erection devices

Mechanical devices can help achieve erection.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccination considerations are associated with this medicine. However, maintain routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. When traveling across time zones, take the medicine as needed for sexual activity, but do not exceed one dose per day. Check local customs regulations regarding prescription medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with erectile dysfunction

He was prescribed this medicine 50 mg. He took it about an hour before sexual activity and noticed significant improvement in his ability to achieve and maintain an erection. He experienced mild headache initially, which resolved after a few doses. He was advised to avoid alcohol and to take the medicine on an empty stomach for faster effect.

💡 Lesson: Taking this medicine as prescribed and avoiding alcohol can improve both efficacy and tolerability.

👤 A 62-year-old man with hypertension and erectile dysfunction

He was started on this medicine 25 mg due to his age and blood pressure medications. He was advised to separate the doses of his alpha-blocker and this medicine by at least 4 hours. He experienced mild dizziness initially but it subsided. His erectile function improved significantly without any serious side effects.

💡 Lesson: Dose adjustment and timing of administration are important in elderly patients and those on blood pressure medications.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after taking it.

Q: Can I take this medicine daily?

A: This medicine is taken as needed, not daily. Do not take more than one dose in 24 hours.

Q: Is it safe to take with alcohol?

A: Alcohol can increase the risk of low blood pressure and dizziness. It is best to avoid or limit alcohol.

Q: What should I do if I get an erection lasting more than 4 hours?

A: Seek immediate medical attention to prevent permanent damage.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

Can I take this medicine long-term?
Will it affect my heart?
Can I drive after taking this medicine?
Does it interact with my blood pressure medicine?
What if I miss a dose?
Can I drink alcohol while taking this?

🔄 Substitutes for agra 50mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

Myth: This medicine is an aphrodisiac.
Fact: This medicine does not cause sexual arousal; it requires sexual stimulation to work.
Myth: This medicine can be taken with nitrates.
Fact: This medicine is contraindicated with nitrates due to the risk of severe hypotension.
Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for men with certain heart conditions or those taking nitrates.

🔄 Alternative Options

Generic Alternatives

Sildenafil 50 mg tablet

Brand Alternatives

Penegra 50 mg tablet
Manforce 50 mg tablet
Suhagra 50 mg tablet
Vigora 50 mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Sildenafil","onset":"30-60 minutes","duration":"4 hours","food_effect":"High-fat meal delays onset"},{"medicine":"Tadalafil","onset":"30-120 minutes","duration":"Up to 36 hours","food_effect":"No significant effect"},{"medicine":"Vardenafil","onset":"25-60 minutes","duration":"4-5 hours","food_effect":"High-fat meal delays onset"}]

Caverta 50 Tablet: Comprehensive Guide to Uses, Side Effects, and Safety

When to Call Your Doctor IMMEDIATELY

What is agra 50mg tablet used for?

🇮🇳 agra 50mg tablet के बारे में (Hindi Summary)

💊 agra 50mg tablet Uses & Benefits

📋 Drug Information

👨‍⚕️ Doctor's Practical Tips

🔍 Is This Medicine Right for Your Symptom?

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take agra 50mg tablet

Dosage Information

Dosage Timeline

🍽️ Food Timing Guide

⏰ What to Do If You Miss a Dose

⚠️ Side Effects of agra 50mg tablet

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🔎 Check Your Other Medicines

🛡️ Safety & Warnings

🚫 Contraindications

⚠️ Warnings & Precautions

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

Additional Safety Advice

👴 Special Considerations for Elderly

💡 For Patients Above 65

🤰 Pregnancy Planning (TTC)

🏥 Post-Surgery Considerations

🦷 Dental Procedures

💚 Lifestyle Tips for Better Results

🏋️ Exercise Considerations

🥗 Diet Recommendations

💼 Impact on Daily Work & Life

🛑 When to Stop This Medicine

📅 Long-Term Use Effects

🌿 Non-Medicine Approaches

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

📦 Storage Guide

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✈️ Traveling with This Medicine

💰 Cost Analysis & Savings

👥 Real Patient Stories

💬 Questions Patients Often Ask

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

🔄 Substitutes for agra 50mg tablet

🛑 Myths vs. Facts

🔄 Alternative Options

Generic Alternatives

Brand Alternatives

📊 Comparison with Similar Medicines

😊 Was this information helpful?

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