aldrate 480mg/20mg tablet - Magaldrate (480mg) + Simethicone (20mg) medicine

Aciloc-S Sugar Free Suspension: Complete Medicine Guide

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🏭 Osho Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 16, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for symptomatic relief of acid indigestion and gas.
Reviewed by
SaathiMed Expert Panel | Oct 16, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in vomit or black, tarry stools
  • Severe abdominal pain
  • Difficulty breathing or swelling of face, lips, or throat
  • Chest pain or irregular heartbeat
  • Confusion or muscle weakness
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is aldrate 480mg/20mg tablet used for?

This medicine is a sugar-free antacid and anti-gas suspension containing magaldrate and simethicone. It provides fast relief from heartburn, acid indigestion, and bloating by neutralizing stomach acid and breaking down gas bubbles.

  • Generic Name: Magaldrate + Simethicone
  • Manufacturer: Osho Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 aldrate 480mg/20mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा मैगल्ड्रेट और सिमेथिकोन का संयोजन है, जिसका उपयोग एसिडिटी, सीने में जलन, गैस और पेट की असुविधा से राहत के लिए किया जाता है। यह शुगर-फ्री है, इसलिए मधुमेह रोगी भी इसका उपयोग कर सकते हैं। यह दवा पेट में एसिड को कम करती है और गैस के बुलबुले को तोड़कर बाहर निकालने में मदद करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में कब्ज, दस्त, मतली और चॉकी स्वाद शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही मापने वाले कप का उपयोग करें। अन्य दवाओं के साथ लेने से पहले 2 घंटे का अंतराल रखें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 aldrate 480mg/20mg tablet Uses & Benefits

[{"condition":"Acid indigestion and heartburn","description":"Provides rapid relief from burning discomfort in the chest and upper abdomen caused by stomach acid.","evidence":"Well-established"},{"condition":"Gas and bloating","description":"Helps relieve abdominal discomfort, bloating, and pressure caused by trapped gas.","evidence":"Well-established"},{"condition":"Gastroesophageal reflux disease (GERD) symptom relief","description":"Used as an adjunct to reduce mild symptoms of acid reflux, though not a primary treatment for severe GERD.","evidence":"Moderate"},{"condition":"Peptic ulcer symptom relief","description":"May be used to alleviate pain and discomfort associated with peptic ulcers, but does not treat the underlying cause.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Prevention of medication-induced stomach upset","description":"Sometimes used to prevent stomach irritation from other medications, but this is not a standard approved use.","evidence":"Limited"}]

Primary treatment for: Acid indigestion

Also treats: Heartburn, Gas and bloating, Gastroesophageal reflux disease (GERD), Peptic ulcer disease

📋 Drug Information

Generic Name(s)Magaldrate + Simethicone
Brand NameAciloc-S Suspension Sugar Free
ManufacturerOsho Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassAntacid + Antiflatulent
Route of AdministrationOral
StorageStore at room temperature (15-30°C). Protect from direct sunlight and moisture. Do not freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine 1 hour after meals and at bedtime for best effect.
2
Shake the bottle well before each use to ensure proper mixing.
3
Use a measuring cup or spoon to get the correct dose; do not use a regular spoon.
4
Separate this medicine from other medications by at least 2 hours to avoid interactions.
5
Do not use for more than 2 weeks without consulting a doctor.
6
If you have kidney disease, consult your doctor before using this medicine.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heartburn
This medicine is commonly used for this symptom.
Likely Use
✅
Bloating and gas
Simethicone helps relieve gas.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMagaldrate is minimally absorbed systemically; its action is primarily local in the stomach. Simethicone is not absorbed from the gastrointestinal tract and is excreted unchanged in the feces.
DistributionSystemic distribution is negligible for both ingredients because they act locally in the gut and are not absorbed into the bloodstream to a significant extent.
Protein BindingNot established from the available information.
MetabolismNeither magaldrate nor simethicone undergoes significant metabolic transformation in the body. Magaldrate is converted to soluble salts in the stomach, and simethicone is chemically inert.
Half-LifeNot applicable, as the medicine acts locally and is not absorbed systemically.
ExcretionMagaldrate's soluble salts may be partially absorbed and excreted renally, but the majority is excreted in the feces. Simethicone is excreted unchanged in the feces.
BioavailabilityNot applicable, as the medicine is intended for local action in the gastrointestinal tract and systemic bioavailability is negligible.
Onset of ActionRelief typically begins within minutes after oral administration.
Peak Plasma TimeNot applicable, as there is no significant systemic absorption.
Duration of ActionSymptomatic relief may last for approximately 1 to 2 hours, depending on the amount of food and acid in the stomach.

How It Works

This medicine combines two active ingredients. Magaldrate is a complex antacid that neutralizes gastric acid by chemical reaction, raising the pH of the stomach contents and reducing the irritant effect of acid on the esophageal and gastric mucosa. Simethicone is a surface-active agent that reduces the surface tension of gas bubbles, causing them to coalesce and break down, which allows for easier expulsion of gas through belching or passing flatus. Together, they provide symptomatic relief from acid-related discomfort and gas.

Mechanism Steps

1
Neutralization of gastric acid: Magaldrate reacts with hydrochloric acid in the stomach to form water and neutral salts, thereby reducing acidity.
2
Reduction of pepsin activity: By raising the pH, magaldrate indirectly reduces the activity of pepsin, an enzyme that can damage the stomach lining in an acidic environment.
3
Breakdown of gas bubbles: Simethicone lowers the surface tension of gas bubbles in the gastrointestinal tract, causing them to merge and break, which facilitates their elimination.
4
Relief of symptoms: The combined actions lead to a reduction in heartburn, acid indigestion, and bloating, providing symptomatic relief.

💡 How to Take aldrate 480mg/20mg tablet

Strength: Each 5 mL contains Magaldrate 480 mg and Simethicone 20 mg.

1Shake the bottle well before each use.
2Measure the dose using the provided measuring cup or spoon.
3Take orally, preferably 1 hour after meals and at bedtime.
4Do not take within 2 hours of other medications.
5Rinse mouth after taking to remove chalky taste.

Dosage Information

Adult DosageThe usual adult dose is 10-20 mL (approximately 480-960 mg magaldrate and 20-40 mg simethicone) taken orally between meals and at bedtime, or as directed by a physician. The dose may be repeated as needed, but do not exceed the recommended maximum daily dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of antacids, especially if they have renal impairment. Use with caution and consult a doctor for appropriate dosing.
Renal ImpairmentUse with caution in patients with renal impairment. Dose reduction or avoidance may be necessary. Consult a doctor.
Hepatic ImpairmentNo specific dosage adjustment is required for hepatic impairment, but consult a doctor.
Maximum Daily DoseDo not exceed 80 mL in 24 hours (approximately 3840 mg magaldrate and 160 mg simethicone) unless directed by a physician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Meals
Take 1 hour after meals
Food buffers the effect; taking after meals prolongs action.
Citrus fruits/juices
Avoid taking with this medicine
Acidic foods may reduce effectiveness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of aldrate 480mg/20mg tablet

✅ Common Side Effects

Constipation (Common (may occur in up to 10%))
Increase fluid and fiber intake. If it persists, consult your doctor.
Diarrhea (Common (may occur in up to 10%))
Stay hydrated. If diarrhea is severe or persistent, seek medical advice.
Nausea (Uncommon (1-5%))
Take with food or milk to reduce nausea. If it continues, consult your doctor.
Chalky taste (Common)
Rinse mouth after taking. This is harmless and temporary.

🚨 Serious Side Effects

Allergic reaction (rash, itching, swelling, difficulty breathing) (Rare (<0.1%))
Seek immediate medical attention if you experience any signs of a severe allergic reaction.
Electrolyte imbalance (e.g., hypermagnesemia) (Rare, mainly with prolonged high-dose use or kidney disease)
Consult a doctor if you experience muscle weakness, confusion, or irregular heartbeat.

⚠️ Rare Side Effects

Aluminum toxicity
Seek medical attention if you develop bone pain, confusion, or seizures.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Tetracycline Major
Fluoroquinolones Major
Iron supplements Moderate
Ketoconazole Moderate
Ampicillin Moderate
Digoxin Minor

🚨 Major Interactions

  • Tetracycline antibiotics
  • Fluoroquinolone antibiotics
  • Iron supplements

⚡ Moderate Interactions

  • Ketoconazole
  • Ampicillin

🍷 Alcohol Interaction

Alcohol can increase stomach acid production and may worsen the condition being treated. It is advisable to avoid or limit alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to magaldrate, simethicone, or any component of the formulation.","Severe renal impairment or renal failure.","Hypophosphatemia.","Bowel obstruction or ileus."]

⚠️ Warnings & Precautions

["Do not use for more than 2 weeks without consulting a doctor.","Use with caution in patients with renal impairment.","May interfere with the absorption of other medications; separate doses.","Not for use in children under 12 years without medical advice.","If symptoms persist or worsen, seek medical attention.","Avoid taking with acidic foods or drinks."]

🤱 Lactation Safety

It is not known whether magaldrate or simethicone pass into breast milk. However, systemic absorption is negligible, so risk to the infant is likely low. Consult your doctor before use while breastfeeding.

💊 Overdose Management

Overdose may cause gastrointestinal discomfort, diarrhea, or electrolyte imbalances. Treatment is symptomatic and supportive. In case of suspected overdose, contact a poison control center or seek immediate medical attention.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as directed by your doctor or as stated on the label. Do not exceed the recommended dose. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring device to get the correct dose. Avoid taking this medicine within two hours of other medications, as it can interfere with their absorption. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before use. Do not use this medicine for more than two weeks unless advised by a doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients, especially those with kidney impairment, should use this medicine with caution due to the risk of electrolyte imbalances. Consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. It is generally considered safe for short-term use, but medical advice is recommended.

🏥 Post-Surgery Considerations

After surgery, consult your doctor before using this medicine, as it may interact with other medications or affect recovery.

🦷 Dental Procedures

No specific precautions for dental procedures. Inform your dentist about all medications you are taking.

💚 Lifestyle Tips for Better Results

🏃
Eat smaller, more frequent meals to reduce acid production.
🥗
Avoid trigger foods like spicy, fatty, or acidic foods.
😴
Maintain a healthy weight to reduce pressure on the stomach.
💧
Avoid lying down immediately after eating.
🧘
Elevate the head of your bed if you have nighttime heartburn.
🌞
Quit smoking and limit alcohol, as both can worsen acidity.

🏋️ Exercise Considerations

Exercise is generally safe while taking this medicine. However, avoid vigorous exercise immediately after meals to prevent reflux. Listen to your body and stay hydrated.

🥗 Diet Recommendations

Include fiber-rich foods like fruits and vegetables.
Choose lean proteins.
Avoid spicy and greasy foods.
Limit caffeine and carbonated drinks.
Stay well hydrated with water.

💼 Impact on Daily Work & Life

This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or drowsiness (rare), avoid these activities until you know how it affects you.

🛑 When to Stop This Medicine

Stop taking this medicine and consult a doctor if your symptoms persist for more than 2 weeks, if they worsen, or if you experience any serious side effects. Do not stop prescribed medications without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine without medical supervision may lead to electrolyte imbalances, especially in patients with kidney disease. It can also mask more serious conditions. Regular monitoring of electrolytes may be needed if used for extended periods. Consult your doctor if you need to use it for more than 2 weeks.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary changes

Avoiding trigger foods can reduce acidity episodes.

Evidence: Well-established
Lifestyle modifications

Weight loss, smoking cessation, and elevating the head of the bed can help.

Evidence: Well-established
Stress reduction

Stress can worsen acid reflux; relaxation techniques may help.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. Continue routine vaccinations as scheduled.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Keep a copy of your prescription or doctor&#039;s note, especially for international travel. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue your regular dosing schedule as close as possible. Check customs regulations for carrying liquids.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 50-year-old man with diabetes and frequent heartburn
He was prescribed this sugar-free suspension for his acidity. He found relief within 10 minutes of taking it after meals. He appreciated that it didn't affect his blood sugar levels.
💡 Lesson: Sugar-free formulations are important for diabetic patients needing antacid therapy.
👤 A 35-year-old woman with bloating and gas after meals
She started taking this medicine after meals and at bedtime. Within a few days, her bloating reduced significantly. She noted that taking it with a measuring cup ensured she didn't overdose.
💡 Lesson: Proper dosing and timing enhance the effectiveness of antacids and anti-gas medicines.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within minutes after taking it.

Q: Can I take it with other medicines?

A: It can interact with several medicines. Separate this medicine from others by at least 2 hours.

Q: Is it safe for diabetics?

A: Yes, this sugar-free formulation is suitable for diabetics.

Q: How often can I take it?

A: Typically after meals and at bedtime, but follow your doctor's advice.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for aldrate 480mg/20mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure ulcers.
    Fact: This medicine only relieves symptoms; it does not treat the underlying cause of ulcers.
  • Myth: It is safe to take indefinitely.
    Fact: Prolonged use without medical supervision can lead to electrolyte imbalances and other issues.
  • Myth: It can be taken with any other medicine.
    Fact: It can interact with several medications, so separation of doses is often necessary.

🔄 Alternative Options

Generic Alternatives

  • Magaldrate and simethicone suspension (various manufacturers)

Brand Alternatives

  • Aciloc-S Suspension Sugar Free

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredients":"Magaldrate + Simethicone","key_feature":"Sugar-free, rapid relief"},{"medicine":"Aluminum/magnesium hydroxide + simethicone","active_ingredients":"Aluminum hydroxide + Magnesium hydroxide + Simethicone","key_feature":"Contains sugar, may cause constipation"},{"medicine":"Calcium carbonate + simethicone","active_ingredients":"Calcium carbonate + Simethicone","key_feature":"May cause acid rebound"}]

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