Ambifast Syrup: Complete Guide to Uses, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or distension
- Chest pain, palpitations, or fainting
- Difficulty breathing or swelling of face, lips, or throat
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Uncontrollable muscle spasms or abnormal movements
- High fever with muscle rigidity and confusion
If experiencing severe symptoms, call emergency services immediately.
What is domar 10mg/480mg/20mg tablet used for?
This medicine is a combination of domperidone and magaldrate used to treat nausea, vomiting, heartburn, and bloating associated with delayed stomach emptying and excess acid. It works by improving stomach motility and neutralising acid. It is available as a syrup and is taken orally before meals.
- Generic Name: Domperidone (10mg) + Magaldrate (480mg)
- Manufacturer: Zaneka Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 domar 10mg/480mg/20mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और मैगल्ड्रेट का संयोजन है, जिसका उपयोग पेट की गड़बड़ी, मतली, उल्टी, सीने में जलन और पेट फूलने के इलाज के लिए किया जाता है। यह पेट को खाली करने में मदद करती है और पेट के एसिड को कम करती है। इसे खाने से 15-30 मिनट पहले लेना चाहिए। इसका उपयोग डॉक्टर की सलाह के बिना न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, पेट में ऐंठन, दस्त या कब्ज शामिल हैं। कभी-कभी स्तनों में दर्द या दूध का स्राव हो सकता है। दुर्लभ मामलों में दिल की धड़कन अनियमित हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न बढ़ाएँ। शराब न पिएँ। अन्य दवाओं के साथ लेने से पहले डॉक्टर से सलाह लें। गर्भवती या स्तनपान कराने वाली महिलाएँ बिना सलाह के इसका उपयोग न करें। बच्चों से दूर रखें। ठंडी और सूखी जगह पर रखें।
💊 domar 10mg/480mg/20mg tablet Uses & Benefits
[{"condition":"Functional dyspepsia","description":"Relieves upper abdominal discomfort, bloating, and early fullness by improving stomach emptying and reducing acid.","evidence":"Well-established"},{"condition":"Gastro-oesophageal reflux disease (GERD)","description":"Reduces heartburn and acid regurgitation by neutralising acid and speeding gastric emptying.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with delayed gastric emptying","description":"Domperidone helps control nausea and vomiting by blocking dopamine receptors in the brain and gut.","evidence":"Well-established"},{"condition":"Gastritis with dyspeptic symptoms","description":"Magaldrate neutralises acid while domperidone improves motility, easing gastritis-related pain.","evidence":"Limited"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes used to improve gastric emptying in diabetic patients, but evidence is limited and it is not a first-line treatment.","evidence":"Limited"},{"condition":"Prevention of nausea during migraine","description":"Domperidone may be used off-label to relieve nausea in migraine, but magaldrate component is not relevant.","evidence":"Limited"}]
Primary treatment for: Functional dyspepsia
Also treats: Gastro-oesophageal reflux disease (GERD), Gastritis, Nausea and vomiting, Diabetic gastroparesis
📋 Drug Information
| Generic Name(s) | Domperidone (10mg) + Magaldrate (480mg) |
| Brand Name | domar 10mg/480mg/20mg tablet |
| Manufacturer | Zaneka Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed. Shake well before each use. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract, which increases lower oesophageal sphincter pressure, enhances gastric and duodenal peristalsis, and accelerates gastric emptying without crossing the blood-brain barrier significantly. Magaldrate is a combination of aluminium and magnesium hydroxides that neutralises gastric acid, raising gastric pH and reducing pepsin activity, thereby relieving acid-related symptoms. The two ingredients together address both motility and acid components of dyspepsia.
Mechanism Steps
💡 How to Take domar 10mg/480mg/20mg tablet
Strength: Each 5 mL of syrup contains Domperidone 10 mg and Magaldrate 480 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mL (containing domperidone 10 mg and magaldrate 480 mg) taken orally three times daily, preferably 15-30 minutes before meals. However, the exact dose and duration depend on the indication, severity of symptoms, and individual patient factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the cardiac effects of domperidone. Use with caution and consider lower doses. Renal and hepatic function should be assessed before starting therapy. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe renal impairment, magaldrate may accumulate and cause toxicity. Domperidone metabolites are renally excreted. Dose reduction or avoidance may be necessary. Consult a nephrologist or clinician for individualized dosing. |
| Hepatic Impairment | Domperidone is extensively metabolised in the liver. In moderate to severe hepatic impairment, its clearance is reduced, increasing the risk of side effects. It is contraindicated in moderate to severe hepatic impairment. In mild impairment, use with caution and consider dose reduction. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose of domperidone is 30 mg (30 mL of this syrup) in adults. Higher doses increase the risk of cardiac arrhythmias. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of domar 10mg/480mg/20mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Amiodarone | Major | |
| Fluconazole | Major | |
| Levodopa | Moderate | |
| Opioids | Moderate | |
| Anticholinergics | Moderate | |
| Iron supplements | Minor | |
| Tetracyclines | Minor | |
| Fluoroquinolones | Minor |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin, ritonavir
- Amiodarone, sotalol, quinidine, haloperidol
- Fluconazole, miconazole (oral gel)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., dicyclomine, hyoscyamine)
- Opioid analgesics (e.g., morphine, codeine)
- Levodopa
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase stomach irritation, worsen acid-related symptoms, and may add to central nervous system effects such as drowsiness or dizziness. It can also delay gastric emptying, reducing the effectiveness of domperidone.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone, magaldrate, or any component of the formulation","Gastrointestinal obstruction, perforation, or active bleeding","Prolactin-releasing pituitary tumour (prolactinoma)","Moderate to severe hepatic impairment","Known QT prolongation or congenital long QT syndrome","Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)","Concomitant use with QT-prolonging drugs (e.g., amiodarone, sotalol)","Severe renal impairment (for magaldrate component)"]
⚠️ Warnings & Precautions
["Use with caution in elderly patients and those with heart disease due to risk of arrhythmias.","Avoid in patients with electrolyte disturbances such as hypokalaemia or hypomagnesaemia.","Do not use for prolonged periods without medical supervision; antacid use should not exceed 2 weeks.","May mask symptoms of gastric cancer; rule out malignancy if symptoms persist.","Avoid in patients with phenylketonuria if the formulation contains aspartame.","Use with caution in patients with diabetes as the syrup may contain sugar.","Do not exceed the recommended dose; higher doses increase risk of cardiac side effects.","Inform your doctor if you are taking any other medicines, especially antifungals, antibiotics, or heart medicines."]
🤱 Lactation Safety
Domperidone passes into breast milk in small amounts. It may increase milk production, but it is not recommended for breastfeeding mothers without medical advice due to potential infant exposure and cardiac risks. Consult your doctor for alternatives.
💊 Overdose Management
Overdose of this medicine may cause drowsiness, confusion, extrapyramidal symptoms, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be given if ingestion is recent. Monitor ECG and vital signs. There is no specific antidote for domperidone. For magaldrate overdose, monitor for diarrhoea and electrolyte imbalances. Contact a poison control centre or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is less than half the dosing interval away. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it for longer than recommended. Shake the bottle well before each use. Avoid alcohol while taking this medicine because it can worsen stomach irritation and increase drowsiness. Do not take antacids or other medicines within two hours of this medicine, as magaldrate can reduce their absorption. Inform your doctor if you have heart problems, kidney disease, liver disease, or low potassium levels. Do not use this medicine if you are pregnant or breastfeeding without medical advice. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of domperidone-induced QT prolongation and cardiac arrhythmias. Use the lowest effective dose and consider ECG monitoring, especially if there is a history of heart disease or concomitant use of QT-prolonging drugs. Renal and hepatic function should be assessed. Magaldrate may cause constipation or electrolyte disturbances in the elderly.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are of childbearing age, consult your doctor before using this medicine. Domperidone should be avoided during pregnancy unless clearly necessary. Magaldrate is generally considered safe but should be used only if needed. Discuss alternative treatments for nausea and heartburn during pregnancy.
🏥 Post-Surgery Considerations
After surgery, gastric motility may be altered. Use this medicine only if prescribed by your surgeon. It may be beneficial for post-operative nausea and vomiting, but domperidone's cardiac risks should be weighed. Magaldrate can be used for stress ulcer prophylaxis if indicated. Always inform your surgeon about all medicines you are taking.
🦷 Dental Procedures
This medicine does not directly affect dental procedures. However, if you are taking it for nausea, inform your dentist. Dry mouth is a common side effect and may increase the risk of dental caries; maintain good oral hygiene and stay hydrated. No need to stop the medicine before dental work unless advised by your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise is generally safe while taking this medicine. However, if you experience dizziness, palpitations, or unusual fatigue, avoid strenuous activities and consult your doctor. Avoid exercising immediately after meals to prevent reflux.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause dry mouth, so keep water handy. Generally, it does not significantly interfere with daily activities if taken as prescribed.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience palpitations, fainting, severe abdominal pain, or allergic reactions. Do not stop abruptly if you have been on long-term therapy without medical advice. Usually, it is prescribed for short-term use; if symptoms persist beyond 2 weeks, consult your doctor for reassessment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of cardiac arrhythmias due to domperidone and electrolyte imbalances or hypophosphataemia due to magaldrate. It should not be used for more than 2 weeks without medical supervision. Regular monitoring of heart rhythm, electrolytes, and renal function may be required. If symptoms persist, consult your doctor for alternative treatments.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Small, frequent, low-fat meals can reduce dyspepsia symptoms.
Evidence: Well-establishedWeight loss, avoiding late meals, and elevating the head of the bed can help GERD.
Evidence: Well-establishedYoga, meditation, and relaxation techniques may reduce functional dyspepsia symptoms.
Evidence: ModerateAlternative acid suppression therapy for GERD and dyspepsia.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. No specific timing adjustments are required.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Shake well before each use
❌ DON'T
Do not use if the suspension has changed colour or consistency
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or doctor's note, especially for international travel. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking doses at regular intervals as prescribed; consult your doctor for specific advice. Do not leave it in a hot car or checked luggage. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Domperidone starts working within 30-60 minutes, and magaldrate provides antacid relief within 5-10 minutes. You may feel improvement in symptoms after the first few doses.
A: It is best taken 15-30 minutes before meals. This timing enhances its prokinetic effect and acid neutralisation.
A: If you remember within half the dosing interval, take it. Otherwise, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Pediatric dosing is not established. Consult a pediatrician before giving this medicine to a child.
A: Consult your doctor. Domperidone is not recommended unless clearly necessary, and magaldrate should be used with medical advice.
🤔 Common Patient Concerns
🔄 Substitutes for domar 10mg/480mg/20mg tablet
View AllAlternative brands with exact same active ingredient:
-
duogel syrupZytras Life Sciences ₹37.73 325.8% COSTLIER
-
kedgel oral gelKedna Pharmaceuticals ₹39.38 344.5% COSTLIER
-
ofcid d suspensionSanjeevani Bio-Tech Pvt Ltd ₹43.00 385.3% COSTLIER
-
domar 10mg/480mg/20mg syrupZaneka Healthcare Pvt Ltd ₹44.48 402% COSTLIER
-
rate 3 syrupWens Drugs India Pvt Ltd ₹54.38 513.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any stomach pain.
Fact: It is specifically for nausea, vomiting, and acid-related dyspepsia. It is not effective for all types of abdominal pain and may be harmful in certain conditions like obstruction. - Myth: It is safe to take this medicine indefinitely.
Fact: Prolonged use of domperidone can increase the risk of heart rhythm problems, and long-term antacid use can cause electrolyte imbalances. It should be used only as prescribed for a limited duration. - Myth: This medicine is safe for children.
Fact: Pediatric dosing is not established. It should not be given to children without a pediatrician's advice.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Magaldrate oral suspension (generic)
Brand Alternatives
- Ambifast Syrup