agroflox m oral suspension - Uses, Price, Side Effects & Substitutes
What is agroflox m oral suspension used for?
Averflox MS Syrup (Ofloxacin + Metronidazole) is used to treat GASTRO INTESTINAL. It contains Ofloxacin (50mg) + Metronidazole (120mg), which Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA rep. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ofloxacin + Metronidazole
- Manufacturer: Aggrowin Pharma
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ agroflox m oral suspension Uses & Benefits
Gastrointestinal infections including diarrhea, dysentery, and mixed infections caused by susceptible bacteria and protozoa
Off-label uses: Helicobacter pylori eradication, Pelvic inflammatory disease, Bacterial vaginosis
๐ Drug Information
| Generic Name(s) | Ofloxacin + Metronidazole |
| Brand Name | Averflox MS Syrup |
| Manufacturer | Aggrowin Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic + Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication. Metronidazole enters bacterial cells and forms toxic compounds that damage DNA.
Mechanism Steps
๐ก How to Take agroflox m oral suspension
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of agroflox m oral suspension
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Metallic taste
- Dizziness
๐จ Serious Side Effects
- Tendonitis/tendon rupture
- Peripheral neuropathy
- QT prolongation
- Seizures
- Pseudomembranous colitis
- Blood dyscrasias
โ ๏ธ Rare Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Hepatotoxicity
- Interstitial nephritis
- Photosensitivity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Disulfiram | Major | Psychotic reactions |
| Alcohol | Major | Disulfiram-like reaction |
| QT-prolonging agents | Major | Increased risk of arrhythmias |
| Antacids | Moderate | Reduced absorption of ofloxacin |
| Sucralfate | Moderate | Reduced absorption of ofloxacin |
| Iron supplements | Moderate | Reduced absorption of ofloxacin |
| Cimetidine | Moderate | Increased metronidazole levels |
| Caffeine | Minor | Reduced caffeine clearance |
| Theophylline | Minor | Increased theophylline levels |
| Cyclosporine | Minor | Increased cyclosporine levels |
๐จ Major Interactions
- Warfarin
- Disulfiram
- Alcohol
- QT-prolonging agents
โก Moderate Interactions
- Antacids
- Sucralfate
- Iron supplements
- Cimetidine
โน๏ธ Minor Interactions
- Caffeine
- Theophylline
- Cyclosporine
๐ฝ๏ธ Food Interactions
Avoid dairy products, antacids, and iron supplements within 2 hours of ofloxacin. Metronidazole may cause disulfiram-like reaction with alcohol.
๐ท Alcohol Interaction
Avoid alcohol during therapy and for 48 hours after last dose due to disulfiram-like reaction (nausea, vomiting, headache).
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to fluoroquinolones or metronidazole, history of tendon disorders with fluoroquinolones, epilepsy, myasthenia gravis, first trimester of pregnancy (metronidazole), concurrent disulfiram use
๐ Monitoring Parameters
Renal function, hepatic function, blood counts, signs of tendonitis, neurological symptoms, QT interval if risk factors
๐คฑ Lactation Safety
Caution: Ofloxacin excreted in breast milk; Metronidazole excreted in breast milk. Use only if clear
๐ Overdose Management
Supportive care; no specific antidote. Hemodialysis may remove ofloxacin and metronidazole.
โฐ Missed Dose
Take as soon as remembered unless almost time for next dose; do not double dose.