aflar 500mg/250mg tablet - Paracetamol (500mg) + Chlorzoxazone (250mg) medicine

Myospaz Tablet: Complete Guide to Uses, Dosage, and Safety

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🏭 Digmedi Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for musculoskeletal pain; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Yellowing of skin or eyes
  • Dark urine
  • Unusual bleeding or bruising
  • Swelling of face, lips, or throat
  • Difficulty breathing

If experiencing severe symptoms, call emergency services immediately.

What is aflar 500mg/250mg tablet used for?

This medicine is a combination of Paracetamol and Chlorzoxazone used for short-term relief of muscle pain and spasm. It works by reducing pain and relaxing muscles. Take it exactly as prescribed and avoid alcohol.

  • Generic Name: Paracetamol (500mg) + Chlorzoxazone (250mg)
  • Manufacturer: Digmedi Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 aflar 500mg/250mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा मांसपेशियों के दर्द और ऐंठन के इलाज के लिए इस्तेमाल की जाती है। इसमें पैरासिटामोल और क्लोरज़ोक्साज़ोन होते हैं, जो दर्द कम करने और मांसपेशियों को आराम देने में मदद करते हैं। यह दवा अल्पकालिक उपयोग के लिए है और इसे डॉक्टर के निर्देशानुसार ही लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, जी मिचलाना, उल्टी, पेट में गड़बड़ी और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में लीवर की क्षति, त्वचा पर गंभीर प्रतिक्रियाएं और रक्त विकार हो सकते हैं। यदि आपको पीलिया, गहरे रंग का मूत्र, या असामान्य रक्तस्राव हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। शराब का सेवन न करें क्योंकि इससे लीवर की क्षति और नींद आने की समस्या बढ़ सकती है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 aflar 500mg/250mg tablet Uses & Benefits

[{"condition":"Musculoskeletal pain and muscle spasm","description":"Relieves pain and relaxes muscles in conditions such as strains, sprains, and other musculoskeletal injuries.","evidence":"Well-established"},{"condition":"Tension headache","description":"May help relieve tension-type headaches associated with muscle tightness.","evidence":"Limited"},{"condition":"Low back pain","description":"Used for short-term relief of acute low back pain accompanied by muscle spasm.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Fibromyalgia","description":"Sometimes prescribed off-label for muscle pain in fibromyalgia, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Musculoskeletal pain and muscle spasm

Also treats: Tension headache, Low back pain

📋 Drug Information

Generic Name(s)Paracetamol (500mg) + Chlorzoxazone (250mg)
Brand Nameaflar 500mg/250mg tablet
ManufacturerDigmedi Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Avoid alcohol completely while taking this medicine.
3
Do not drive or operate heavy machinery until you know how it affects you.
4
Do not exceed the prescribed dose; too much paracetamol can harm your liver.
5
Use this medicine for the shortest duration necessary.
6
Consult your doctor if pain persists beyond 7 days.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Muscle pain
This medicine is commonly prescribed for this.
Likely Use
✅
Muscle spasm
This medicine helps relax muscles.
Likely Use
❌
Fever
This medicine is not a primary fever reducer, though paracetamol has antipyretic effects.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Chlorzoxazone is also absorbed from the gastrointestinal tract. Food may delay absorption slightly.
DistributionParacetamol distributes widely into most body tissues. Chlorzoxazone distribution is not well characterized.
Protein BindingParacetamol is minimally bound to plasma proteins. Chlorzoxazone protein binding is not established from the available information.
MetabolismParacetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione. Chlorzoxazone is extensively metabolized in the liver, primarily by CYP2E1.
Half-LifeParacetamol elimination half-life is approximately 2-3 hours. Chlorzoxazone half-life is approximately 1-2 hours.
ExcretionParacetamol metabolites are excreted primarily in urine. Chlorzoxazone metabolites are excreted in urine.
BioavailabilityParacetamol oral bioavailability is high (about 80-100%). Chlorzoxazone bioavailability is not well established.
Onset of ActionParacetamol onset of analgesia is within 30-60 minutes. Chlorzoxazone onset of muscle relaxation is within 1 hour.
Peak Plasma TimeParacetamol peak plasma levels occur within 0.5-2 hours. Chlorzoxazone peak levels occur within 1-2 hours.
Duration of ActionParacetamol analgesia lasts 4-6 hours. Chlorzoxazone muscle relaxation lasts 4-6 hours.

How It Works

This medicine combines two active ingredients. Paracetamol reduces pain and fever by acting primarily in the central nervous system, though its exact mechanism is not fully understood. Chlorzoxazone is a centrally acting muscle relaxant that inhibits polysynaptic reflexes in the spinal cord and brain, reducing muscle spasm and associated pain.

Mechanism Steps

1
Paracetamol central analgesia: Paracetamol acts on the central nervous system to reduce pain perception and lower fever, possibly by inhibiting prostaglandin synthesis in the brain.
2
Chlorzoxazone muscle relaxation: Chlorzoxazone inhibits polysynaptic reflexes in the spinal cord and brain, leading to relaxation of skeletal muscles and relief of spasm.

💡 How to Take aflar 500mg/250mg tablet

Strength: Tablet containing Paracetamol 500 mg and Chlorzoxazone 250 mg.

1Take this medicine orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take it at the same times each day as prescribed.
5Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally two to three times a day, or as directed by your doctor. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the maximum recommended daily dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects, especially drowsiness and dizziness. Use with caution and adjust dose as needed under medical supervision.
Renal ImpairmentDose adjustment may be needed in patients with kidney disease. Consult your doctor.
Hepatic ImpairmentDose adjustment may be needed in patients with liver disease. Consult your doctor.
Maximum Daily DoseThe maximum daily dose of paracetamol should not exceed 4000 mg (8 tablets of 500 mg) from all sources. Chlorzoxazone maximum daily dose is not well established; follow your doctor's prescription.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of aflar 500mg/250mg tablet

✅ Common Side Effects

Drowsiness (Common (5-10%))
Avoid driving or operating machinery. Usually resolves with continued use.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Consult doctor if persistent.
Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset.
Stomach upset (Common (5-10%))
Take with meals. Consult doctor if severe.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.

🚨 Serious Side Effects

Liver damage (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Severe skin reactions (Rare (<0.1%))
Stop the medicine and seek immediate medical help if you develop rash, blistering, or peeling skin.
Blood disorders (Rare (<0.1%))
Report unusual bleeding, bruising, or signs of infection to your doctor immediately.

⚠️ Rare Side Effects

Anaphylaxis
Seek emergency medical help if you experience swelling of face, lips, throat, or difficulty breathing.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
CNS depressants Moderate
Isoniazid Moderate
Carbamazepine Minor

🚨 Major Interactions

  • Warfarin
  • Alcohol

⚡ Moderate Interactions

  • CNS depressants (e.g., benzodiazepines, opioids)
  • Isoniazid

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and enhances drowsiness caused by chlorzoxazone.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to paracetamol or chlorzoxazone","Severe liver disease","Severe kidney disease","Chronic alcohol use"]

⚠️ Warnings & Precautions

["Avoid alcohol while taking this medicine.","Do not exceed the recommended dose.","May cause drowsiness; avoid driving or operating machinery.","Use with caution in patients with liver or kidney disease.","Consult a doctor if symptoms persist beyond 7 days."]

🤱 Lactation Safety

Paracetamol is considered safe during breastfeeding. Chlorzoxazone may pass into breast milk; consult your doctor before use.

💊 Overdose Management

Overdose can cause severe liver damage, nausea, vomiting, and abdominal pain. Seek immediate medical attention. Treatment may include activated charcoal, acetylcysteine, and supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and drowsiness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have liver or kidney disease, or if you are pregnant or breastfeeding. Do not use this medicine for longer than recommended without medical advice. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Use with caution and adjust dose as needed under medical supervision.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The safety of this combination during pregnancy is not well established.

🏥 Post-Surgery Considerations

Consult your doctor before taking this medicine after surgery, as it may interact with other medications or affect recovery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may interact with anesthetics or other medications.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce strain on muscles and joints.
🥗
Regular low-impact exercise like swimming or walking can help prevent muscle spasms.
😴
Practice good posture to avoid muscle strain.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep to promote muscle recovery.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, as it may cause drowsiness and dizziness. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce processed food intake.
Stay well hydrated.
Eat plenty of fruits and vegetables.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness and dizziness, affecting your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also affect your ability to concentrate.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of paracetamol can increase the risk of liver and kidney damage. Chlorzoxazone may cause rare liver toxicity. Regular monitoring of liver function may be needed if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and muscle spasm.

Evidence: Well-established
Heat or cold therapy

May help relieve muscle pain and spasm.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for controlled substances.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute low back pain and muscle spasm
Started this medicine as prescribed for low back pain. Within a few days, noticed significant relief in muscle spasm and pain. Emphasized taking it with food to avoid stomach upset and avoiding alcohol.
💡 Lesson: Taking this medicine with food and avoiding alcohol improves tolerability and safety.
👤 A 60-year-old retiree with neck muscle spasm
Prescribed this medicine for neck spasm. Experienced drowsiness initially, so avoided driving. After a week, symptoms improved. Doctor advised physical therapy alongside.
💡 Lesson: Drowsiness is common; avoid driving until you know how the medicine affects you. Combining with physical therapy can enhance recovery.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food to reduce stomach upset.

Q: Is it safe to take with other painkillers?

A: Do not take additional paracetamol-containing products without consulting your doctor, as this can lead to overdose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for aflar 500mg/250mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken long-term without any risk.
    Fact: This medicine is for short-term use only. Prolonged use can increase the risk of liver and kidney problems.
  • Myth: It is safe to drink alcohol while taking this medicine.
    Fact: Alcohol increases the risk of liver damage and drowsiness. Avoid alcohol completely.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol + Chlorzoxazone generic tablets

Brand Alternatives

  • Myospaz Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Paracetamol + Chlorzoxazone","uses":"Muscle pain and spasm","side_effects":"Drowsiness, dizziness, nausea"},{"medicine":"Paracetamol + Aceclofenac","uses":"Pain and inflammation","side_effects":"Stomach upset, bleeding risk"}]

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