Arsufact 50mg Tablet (Artesunate): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe skin rash or itching
- Yellowing of the skin or eyes
- Dark urine or decreased urine output
- Unusual bleeding or bruising
- Severe abdominal pain or persistent vomiting
- Chest pain, palpitations, or fainting
- Confusion, seizures, or severe headache
- High fever that does not improve after 48 hours of treatment
If experiencing severe symptoms, call emergency services immediately.
What is afalsi 50mg tablet used for?
This medicine is an oral antimalarial containing artesunate 50 mg. It is used to treat malaria, especially severe cases, and works by killing the malaria parasite in the blood. It is always used as part of combination therapy and must be taken exactly as prescribed.
- Generic Name: Artesunate
- Manufacturer: Mediwin Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 afalsi 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मलेरिया के इलाज के लिए इस्तेमाल की जाती है, खासकर प्लास्मोडियम फाल्सीपेरम के कारण होने वाले गंभीर मलेरिया में। यह आर्टेसुनेट 50 मिलीग्राम की गोली है जो मलेरिया परजीवी को खून में मारती है। इसे हमेशा डॉक्टर की सलाह से और पूरे कोर्स के रूप में लेना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में सिरदर्द, चक्कर आना, जी मिचलाना, उल्टी, पेट दर्द और भूख न लगना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, खून की समस्या, लिवर की समस्या और दिल की धड़कन में बदलाव हो सकते हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुद से दवा न बंद करें, पूरा कोर्स पूरा करें। इसे भोजन के साथ लें। शराब न पिएं। अगर आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। दवा को ठंडी और सूखी जगह पर रखें। बच्चों की पहुंच से दूर रखें।
💊 afalsi 50mg tablet Uses & Benefits
[{"condition":"Plasmodium falciparum malaria","description":"This medicine is used to treat uncomplicated and severe malaria caused by Plasmodium falciparum, often as part of artemisinin-based combination therapy (ACT).","evidence":"Well-established"},{"condition":"Severe malaria (when oral therapy is appropriate)","description":"In cases where intravenous therapy is not feasible, oral artesunate may be used for severe malaria, but only under close medical supervision.","evidence":"Established"},{"condition":"Malaria due to other Plasmodium species","description":"This medicine may be used for malaria caused by Plasmodium vivax, ovale, or malariae, but usually in combination with other antimalarials to ensure radical cure.","evidence":"Limited"}]
Off-label uses: [{"condition":"Schistosomiasis","description":"Artesunate has shown activity against Schistosoma species in some studies, but it is not a standard treatment and should only be used under research settings.","evidence":"Limited"},{"condition":"Cancer (experimental)","description":"Preclinical studies suggest artesunate may have anticancer properties, but this is not an approved use and clinical trials are ongoing.","evidence":"Experimental"}]
Primary treatment for: Malaria
Also treats: Severe malaria, Cerebral malaria, Plasmodium vivax malaria (in combination)
📋 Drug Information
| Generic Name(s) | Artesunate |
| Brand Name | Azunate |
| Manufacturer | Mediwin Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial- Artemisinin and derivatives |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends artesunate as the first-line treatment for severe malaria in adults and children, including in pregnancy. For uncomplicated malaria, artesunate should be used as part of artemisinin-based combination therapy (ACT). |
| ICMR Guideline | The Indian Council of Medical Research recommends artesunate-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria in India, following national drug policy guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains artesunate, a derivative of artemisinin. Once inside the malaria parasite, artesunate is activated by iron, particularly heme iron released from hemoglobin digestion. The activated artesunate generates free radicals and alkylates multiple parasite proteins, including the sarco-endoplasmic reticulum calcium ATPase (SERCA) and the translationally controlled tumor protein (TCTP). This leads to disruption of parasite protein synthesis, membrane function, and mitochondrial electron transport, ultimately causing rapid parasite death. Artesunate is effective against both asexual and sexual blood stages of the parasite, including young ring stages, which helps prevent progression to severe disease.
Mechanism Steps
💡 How to Take afalsi 50mg tablet
Strength: Artesunate 50 mg immediate-release tablet for oral administration.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 4 mg per kilogram of body weight once daily for 3 days, but the exact dose and duration depend on the type and severity of malaria, patient weight, and whether it is used as part of combination therapy. For uncomplicated Plasmodium falciparum malaria, it is typically combined with a partner drug such as mefloquine or lumefantrine. For severe malaria, a higher initial dose may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In general, artesunate is used in children at doses based on body weight, but this must be determined by a qualified clinician. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects. Dose adjustment is not typically required based on age alone, but caution is advised, and monitoring for liver, kidney, and cardiac function is recommended. Consult a doctor for individualized dosing. |
| Renal Impairment | No specific dose adjustment is recommended for renal impairment, but caution is advised. Monitor renal function closely. Consult a doctor for individualized dosing. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is usually necessary. In severe hepatic impairment, use with caution and monitor liver function. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on body weight and clinical indication. It should not exceed the dose prescribed by a qualified clinician. Typically, doses up to 4 mg/kg/day are used, but higher doses may be given for severe malaria under medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of afalsi 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Mefloquine | Major | |
| Amiodarone | Major | |
| Warfarin | Moderate | |
| Ritonavir | Moderate | |
| Carbamazepine | Moderate | |
| Antacids | Minor | |
| Hormonal contraceptives | Moderate | |
| Phenytoin | Moderate | |
| Efavirenz | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Other antimalarials (e.g., mefloquine, lumefantrine)
- Drugs that prolong QT interval (e.g., amiodarone, sotalol, macrolides)
- Hormonal contraceptives
⚡ Moderate Interactions
- Warfarin
- Antiretroviral drugs (e.g., ritonavir, efavirenz)
- Anticonvulsants (e.g., carbamazepine, phenytoin)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol may worsen side effects such as dizziness, nausea, and abdominal pain, and can increase the risk of liver toxicity. It may also impair judgment and increase the risk of accidents.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to artesunate or other artemisinin derivatives","First trimester of pregnancy (unless life-threatening severe malaria and no safer alternative)","Severe hepatic impairment (relative contraindication; use with caution)","Concurrent use with drugs that strongly prolong QT interval (relative contraindication)"]
⚠️ Warnings & Precautions
["This medicine should only be used for confirmed or suspected malaria under medical supervision.","Do not use as monotherapy for uncomplicated malaria; always use in combination with a partner antimalarial drug to prevent resistance.","Complete the full prescribed course even if symptoms improve.","Avoid alcohol during treatment.","Use with caution in patients with liver or kidney disease.","Monitor for signs of allergic reactions.","Not recommended for self-medication.","Keep out of reach of children.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Do not share this medicine with others."]
🤱 Lactation Safety
Artesunate and its metabolite are excreted in small amounts in breast milk. It is generally considered safe during breastfeeding, but consult your doctor to weigh the benefits and risks. Monitor the infant for any unusual symptoms.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, dizziness, and potentially serious blood or liver abnormalities. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs, blood counts, and liver function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop treatment early, even if you feel better. Complete the full course to ensure the malaria parasite is fully cleared and to prevent resistance. Take this medicine with food to enhance absorption and reduce stomach upset. Avoid alcohol while taking this medicine, as it may worsen side effects and affect liver function. Inform your doctor if you have liver or kidney problems, heart conditions, or blood disorders before starting this medicine. Do not take this medicine if you are allergic to artesunate or other artemisinin derivatives. If you are pregnant or breastfeeding, consult your doctor before use; artesunate may be used in pregnancy for severe malaria but only under medical supervision. Keep this medicine out of reach of children. Store in a cool, dry place away from direct sunlight. Do not share this medicine with others, even if they have similar symptoms. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. If you experience any severe side effects, contact your doctor immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, particularly dizziness, nausea, and blood disorders. Use with caution and monitor liver, kidney, and cardiac function. Dose adjustment is not usually required based on age alone, but individualized dosing by a clinician is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Artesunate is generally avoided in the first trimester unless absolutely necessary. If you become pregnant while taking this medicine, inform your doctor immediately. Effective contraception is advised during treatment and for a short period after.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may affect blood clotting and liver function. Your doctor will decide whether to continue or temporarily stop the medicine based on your condition.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may increase the risk of bleeding, and your dentist may take precautions. Good oral hygiene is important, but avoid unnecessary dental work during acute malaria.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel weak or dizzy. Avoid strenuous exercise until you have fully recovered from malaria. Light activities like walking are fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and fatigue, which can affect your ability to drive or operate machinery. Avoid driving until you know how the medicine affects you. Take rest as needed. Most people can resume normal activities after completing treatment and recovering from malaria.
🛑 When to Stop This Medicine
Do not stop taking this medicine before completing the full prescribed course, even if you feel better. Stopping early can lead to relapse and drug resistance. If you experience severe side effects, contact your doctor immediately; they will advise whether to stop or adjust treatment.
📅 Long-Term Use Effects
Long-term use of artesunate is not typically recommended beyond the standard 3-day treatment course for malaria. Prolonged use may increase the risk of blood disorders, liver enzyme elevations, and neurological effects, though these are rare. If repeated courses are needed, monitoring of blood counts, liver function, and cardiac function is advised. Always consult a doctor before using this medicine for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another artemisinin-based combination therapy for uncomplicated malaria.
Evidence: Well-establishedAn alternative for malaria treatment when artemisinin-based therapies are not available or contraindicated.
Evidence: EstablishedFor travelers, preventive medicines like atovaquone-proguanil or doxycycline may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are acutely ill with malaria, it is best to postpone non-urgent vaccinations until you have recovered. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from light and moisture. If crossing time zones, consult your doctor about adjusting dosing times. Check customs regulations for carrying prescription medicines. Always carry enough for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 24 hours, with fever and other symptoms improving within 1-2 days. However, you must complete the full course to ensure all parasites are cleared.
A: Yes, it is best taken with food, especially a fatty meal, to improve absorption and reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Artesunate is considered safe in the second and third trimesters and is the treatment of choice for severe malaria in pregnancy. In the first trimester, it should be used only if clearly needed. Consult your doctor.
A: It is advisable to avoid alcohol as it may worsen side effects and increase the risk of liver toxicity.
A: Store at room temperature between 15°C and 30°C, away from light and moisture. Keep in the original container and out of reach of children.
🤔 Common Patient Concerns
🔄 Substitutes for afalsi 50mg tablet
View AllAlternative brands with exact same active ingredient:
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aarnet 50mg tabletAlpha Aromatic Pvt Ltd ₹40.00 78.7% CHEAPER
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bpther 50mg tabletBaltic Pharmaceuticals ₹40.00 78.7% CHEAPER
-
l sunate tabletLeben Laboratories Pvt Ltd ₹41.95 77.6% CHEAPER
-
tesunate 50mg tabletMcW Healthcare ₹46.32 75.3% CHEAPER
-
arteross tabletWockhardt Ltd ₹47.50 74.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Artesunate can be taken alone for malaria.
Fact: Artesunate should always be used in combination with another antimalarial to prevent resistance and ensure cure. - Myth: You can stop taking artesunate once fever subsides.
Fact: You must complete the full course even if symptoms improve, to clear all parasites and prevent relapse. - Myth: Artesunate is safe for everyone.
Fact: It is not safe for people with known allergies to artemisinin derivatives and should be used with caution in pregnancy and liver disease. - Myth: Artesunate can be used to prevent malaria.
Fact: Artesunate is for treatment, not prevention. Preventive measures include mosquito avoidance and prophylactic drugs.
🔄 Alternative Options
Generic Alternatives
- Artesunate 50 mg tablet (generic)
Brand Alternatives
- Arsufact 50mg Tablet