aedicold np tablet - Caffeine (25mg) + Cetirizine (5mg) medicine

Aedicold NP Tablet - Uses, Price, Side Effects

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🏭 Aadi Health Care 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

What is aedicold np tablet used for?

Aedicold NP Tablet is a combination medicine containing Caffeine (25mg) and Cetirizine (5mg). It is used to relieve symptoms of the common cold and allergies, such as sneezing, runny nose, nasal congestion, and watery eyes. Caffeine acts as a mild stimulant to reduce fatigue, while Cetirizine is an antihistamine that blocks histamine to alleviate allergic reactions. It is typically taken twice daily, morning and evening, with or without food.

  • Generic Name: Caffeine + Cetirizine
  • Manufacturer: Aadi Health Care
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 aedicold np tablet Uses & Benefits

Symptomatic relief of allergic rhinitis, urticaria, and common cold symptoms.

Off-label uses: Motion sickness (cetirizine), adjunct in weight loss (caffeine).

📋 Drug Information

Generic Name(s)Caffeine + Cetirizine
Brand NameAzicold Plus Tablet
ManufacturerAadi Health Care
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + CNS Stimulant
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCetirizine is rapidly absorbed after oral administration; caffeine is well absorbed from the GI tract.
DistributionCetirizine is distributed throughout the body; caffeine crosses the blood-brain barrier and placenta.
Protein BindingCetirizine: ~93% bound to plasma proteins; Caffeine: ~35% bound.
MetabolismCetirizine undergoes minimal hepatic metabolism; caffeine is primarily metabolized by CYP1A2 in the liver.
Half-LifeCetirizine: ~8-11 hours; Caffeine: ~3-5 hours.
ExcretionCetirizine is primarily excreted unchanged in urine; caffeine metabolites are excreted in urine.
BioavailabilityCetirizine: ~70%; Caffeine: ~100%.
Onset of ActionCetirizine: 1 hour; Caffeine: 30-45 minutes.
Peak Plasma TimeCetirizine: 1 hour; Caffeine: 1-2 hours.
Duration of ActionCetirizine: 24 hours; Caffeine: 4-6 hours.

How It Works

Cetirizine selectively inhibits peripheral H1 receptors; caffeine antagonizes adenosine receptors and inhibits phosphodiesterase.

Mechanism Steps

1Cetirizine binds to H1 receptors on target cells, blocking histamine binding.
2Inhibition of histamine reduces vasodilation, vascular permeability, and pruritus.
3Caffeine antagonizes adenosine receptors, preventing adenosine-induced sedation and vasodilation.
4Caffeine inhibits phosphodiesterase, increasing cAMP levels, leading to CNS stimulation.
5Combined effects provide relief from allergy symptoms and fatigue.

💡 How to Take aedicold np tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of aedicold np tablet

✅ Common Side Effects

Drowsiness
Dry mouth
Headache
Nervousness
Insomnia

🚨 Serious Side Effects

Severe allergic reactions
Tachycardia
Seizures (caffeine overdose)

⚠️ Rare Side Effects

Hepatotoxicity
Thrombocytopenia
Angioedema

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Alcohol Moderate Increased drowsiness and dizziness
CNS Depressants Moderate Enhanced sedative effect
MAO Inhibitors Major Risk of hypertensive crisis

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • CYP1A2 inhibitors (e.g., ciprofloxacin)

⚡ Moderate Interactions

  • Alcohol
  • Sedatives
  • Anticholinergics

🍷 Alcohol Interaction

Increased sedation and impaired coordination; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cetirizine or caffeine, severe hypertension, arrhythmias, peptic ulcer.

🤱 Lactation Safety

Cetirizine and caffeine are excreted in breast milk; use with caution.

💊 Overdose Management

Supportive care; activated charcoal if recent ingestion; monitor for CNS stimulation and cardiac effects.

⏰ Missed Dose

Take as soon as remembered; skip if almost time for next dose; do not double dose.

🔄 Substitutes for aedicold np tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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