Advadox 20mg Injection - Uses, Price, Side Effects
What is advadox 20mg injection used for?
Advadox 20mg Injection contains liposomal doxorubicin, a chemotherapy drug used to treat various cancers including ovarian cancer, multiple myeloma, and Kaposi's sarcoma. It works by inhibiting DNA replication in cancer cells, slowing tumor growth. Administered intravenously under medical supervision.
- Generic Name: Doxorubicin
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ advadox 20mg injection Uses & Benefits
Breast cancer, ovarian cancer, bladder cancer, thyroid cancer, gastric cancer, Hodgkin's lymphoma, non-Hodgkin's lymphoma, multiple myeloma, sarcoma, acute lymphoblastic leukemia, acute myeloid leukemia.
Off-label uses: Hepatocellular carcinoma, endometrial cancer, Wilms tumor, Ewing sarcoma.
๐ Drug Information
| Generic Name(s) | Doxorubicin |
| Brand Name | Adriamycin |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkaloids-cytotoxic agents |
| Route of Administration | Intravenous (IV) only; avoid intramuscular or subcutaneous. |
| Storage | Store at 2-8ยฐC. Protect from light. Reconstituted solution stable for 24 hours at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Intercalates between DNA base pairs, inhibits topoisomerase II, and generates free radicals leading to DNA damage and cell death.
Mechanism Steps
๐ก How to Take advadox 20mg injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of advadox 20mg injection
โ Common Side Effects
- Nausea
- vomiting
- alopecia
- myelosuppression
- mucositis
- stomatitis
- red urine
๐จ Serious Side Effects
- Cardiomyopathy
- congestive heart failure
- severe myelosuppression
- secondary leukemia
- tumor lysis syndrome
- extravasation necrosis
โ ๏ธ Rare Side Effects
- Hemolytic uremic syndrome
- pulmonary fibrosis
- hepatic veno-occlusive disease
- anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Cyclophosphamide | Moderate | Increased cardiotoxicity |
| Paclitaxel | Moderate | Increased myelosuppression |
๐จ Major Interactions
- Cyclophosphamide
- Trastuzumab
- Paclitaxel
- Radiation therapy
โก Moderate Interactions
- Verapamil
- Dexrazoxane
- Phenobarbital
โน๏ธ Minor Interactions
- Digoxin
- Heparin
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol due to potential hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Severe hepatic impairment, severe myelosuppression, pre-existing cardiomyopathy, hypersensitivity, pregnancy.
๐ Monitoring Parameters
CBC with differential, liver function tests, cardiac function (LVEF), renal function, uric acid levels.
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk.
๐ Overdose Management
Supportive care; severe myelosuppression may require G-CSF and antibiotics. Dexrazoxane may be used for extravasation or cardiotoxicity.
โฐ Missed Dose
Do not double dose. Contact physician for rescheduling.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for advadox 20mg injection
View AllAlternative brands with exact same active ingredient (Doxorubicin (Liposomal) (20mg)):
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pegadria 20mg injectionIntas Pharmaceuticals Ltd โน2,879.50 64.3% CHEAPER
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Natdox-LP InjectionNatco Pharma Ltd โน3,282.65 59.3% CHEAPER
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lipopeg 20mg injectionRPG Life Sciences Ltd โน3,395.00 57.9% CHEAPER
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nudoxa 20mg injectionZydus Cadila โน4,353.04 46% CHEAPER
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adrisome 20mg injectionAureate Healthcare Pvt Ltd โน4,780.00 40.7% CHEAPER
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lippod 20mg injectionCelon Laboratories Ltd โน6,547.62 18.8% CHEAPER
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lipeg 20mg injectionClaris Lifesciences Ltd โน6,614.28 18% CHEAPER
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lipisol 20mg injectionAlkem Laboratories Ltd โน7,600.00 5.8% CHEAPER
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oncodox 20mg injectionCipla Ltd โน8,500.00 5.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.