adiflam plus 400 mg/500 mg tablet
What is adiflam plus 400 mg/500 mg tablet used for?
Adiflam Plus 400 mg/500 mg Tablet (Ibuprofen + Paracetamol) is used to treat PAIN ANALGESICS. It contains Ibuprofen (400mg) + Paracetamol (500mg), which Ibuprofen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamo. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ibuprofen + Paracetamol
- Manufacturer: Leben Life Sciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ adiflam plus 400 mg/500 mg tablet Uses & Benefits
Mild to moderate pain, fever, inflammation (e.g., headache, dental pain, dysmenorrhea, osteoarthritis).
Off-label uses: Patent ductus arteriosus closure (ibuprofen), migraine (paracetamol).
๐ Drug Information
| Generic Name(s) | Ibuprofen + Paracetamol |
| Brand Name | Adiflam Plus 400 mg/500 mg Tablet |
| Manufacturer | Leben Life Sciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ibuprofen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in CNS, reducing pain and fever.
Mechanism Steps
๐ก How to Take adiflam plus 400 mg/500 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of adiflam plus 400 mg/500 mg tablet
โ Common Side Effects
- Nausea
- Dyspepsia
- Headache
- Dizziness
- Rash
๐จ Serious Side Effects
- GI bleeding
- Renal failure
- Hepatotoxicity
- Cardiovascular events
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Aplastic anemia
- Agranulocytosis
- Pancreatitis
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels |
| Aspirin | Major | Increased GI bleeding risk |
| Other NSAIDs | Major | Additive GI and renal toxicity |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Diuretics | Moderate | Reduced diuretic effect |
| Anticoagulants | Moderate | Increased bleeding risk |
| Corticosteroids | Moderate | Increased GI ulcer risk |
| Antacids | Minor | Reduced absorption of ibuprofen |
| Caffeine | Minor | Additive analgesic effect |
| Cholestyramine | Minor | Reduced absorption of paracetamol |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
- Other NSAIDs
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- Corticosteroids
โน๏ธ Minor Interactions
- Antacids
- Caffeine
- Cholestyramine
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid high-fat meals.
๐ท Alcohol Interaction
Increased risk of GI bleeding and hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active GI bleeding, severe renal/hepatic impairment, third trimester pregnancy, history of asthma with NSAIDs.
๐ Monitoring Parameters
Renal function, hepatic function, blood pressure, signs of GI bleeding.
๐คฑ Lactation Safety
Ibuprofen: Safe in low doses; Paracetamol: Safe.
๐ Overdose Management
Activated charcoal, supportive care; for paracetamol overdose: N-acetylcysteine.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Effective and reliable. Worked as expected.
Effective and reliable. Worked as expected.
Effective and reliable. Worked as expected.
This medicine was effective for me. I followed the doctor's advice.
Helpful and effective medicine as per my experience. Always consult a doctor.