Adiflam Plus 400 mg/500 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is cetafen 400mg/500mg tablet used for?
This medicine is a combination of ibuprofen 400 mg and paracetamol 500 mg used for short-term relief of moderate to severe pain and fever. It works by reducing inflammation and pain through two different mechanisms. It is usually taken every 6 to 8 hours with food, not exceeding 3 tablets in 24 hours.
- Generic Name: Ibuprofen + Paracetamol
- Manufacturer: Waksman Selman Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cetafen 400mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन 400 मिलीग्राम और पैरासिटामोल 500 मिलीग्राम का संयोजन है। इसका उपयोग मध्यम से गंभीर दर्द और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, मासिक धर्म के दर्द, सर्जरी के बाद के दर्द, और गठिया के दर्द में प्रभावी है। यह सूजन को कम करने और दर्द को शांत करने में मदद करती है। इसे भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट में जलन, मतली, उल्टी, सिरदर्द, चक्कर आना और दस्त शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, और गंभीर एलर्जी प्रतिक्रिया शामिल हैं। यदि आपको काला मल, खून की उल्टी, तेज पेट दर्द, या आंखों का पीलापन दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन बिल्कुल न करें। पैरासिटामोल या अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको पेट अल्सर, गुर्दे या यकृत की बीमारी, हृदय रोग, या अस्थमा है तो डॉक्टर को बताएं। गर्भावस्था के अंतिम तीन महीनों में इसका उपयोग न करें।
💊 cetafen 400mg/500mg tablet Uses & Benefits
[{"condition":"Musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as back pain, muscle strains, and sprains.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides effective short-term relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for moderate pain after minor surgeries, often as part of multimodal analgesia.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Reduces menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Fever","description":"Paracetamol component helps reduce fever, while ibuprofen adds anti-inflammatory effect.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Short-term relief of pain and stiffness in osteoarthritis flare-ups.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Used for symptomatic relief of pain and swelling in rheumatoid arthritis.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not a first-line treatment.","evidence":"Limited"},{"condition":"Sore throat","description":"Can relieve pain and inflammation in pharyngitis, but usually short-term.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Fever, Dysmenorrhea, Osteoarthritis, Rheumatoid arthritis, Dental pain, Post-operative pain
📋 Drug Information
| Generic Name(s) | Ibuprofen + Paracetamol |
| Brand Name | Adiflam Plus 400 mg/500 mg Tablet |
| Manufacturer | Waksman Selman Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep away from moisture and direct sunlight. Store in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Ibuprofen is a non-selective non-steroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes COX-1 and COX-2, reducing the synthesis of prostaglandins, prostacyclin, and thromboxane. This leads to decreased inflammation, pain, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis with minimal anti-inflammatory effect. The combination provides additive pain relief through complementary pathways.
Mechanism Steps
💡 How to Take cetafen 400mg/500mg tablet
Strength: Tablet containing Ibuprofen 400 mg and Paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain or fever. Do not exceed 3 tablets in 24 hours. The maximum daily dose should not exceed 1200 mg of ibuprofen and 1500 mg of paracetamol from all sources. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Use the lowest effective dose for the shortest possible duration. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Consult a doctor before use. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | Maximum 3 tablets in 24 hours. Do not exceed 1200 mg ibuprofen and 1500 mg paracetamol from all sources per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cetafen 400mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics
- Lithium
- SSRIs
- Antihypertensives
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding caused by ibuprofen and enhances the potential for liver damage from paracetamol. Even moderate alcohol consumption can significantly increase these risks.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active or history of peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe kidney disease","Severe liver disease","Known allergy to ibuprofen, paracetamol, or other NSAIDs","History of asthma, urticaria, or allergic reaction after taking aspirin or other NSAIDs","Third trimester of pregnancy","Children under 12 years of age"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach irritation.","Do not exceed the recommended dose or duration without medical advice.","Avoid alcohol completely.","Do not take other paracetamol-containing products simultaneously.","Use with caution in the elderly due to increased risk of side effects.","Consult your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma.","Stop the medicine and seek medical help if you experience signs of bleeding, liver problems, or allergic reactions.","Do not use for more than 3 days for fever or 10 days for pain without consulting a doctor."]
🤱 Lactation Safety
Ibuprofen is considered compatible with breastfeeding as only small amounts pass into breast milk. Paracetamol is also considered safe during breastfeeding. However, consult your doctor before using this medicine while breastfeeding, especially for prolonged periods.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage from paracetamol and gastrointestinal bleeding, kidney injury, and central nervous system effects from ibuprofen. If you suspect an overdose, seek emergency medical care immediately, even if you feel well. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not wait for symptoms to appear.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or use it for longer than advised without medical supervision. Take it with food or milk to reduce stomach upset. Avoid alcohol completely while taking this medicine because it increases the risk of stomach bleeding and liver damage. Do not take other medicines containing paracetamol or other NSAIDs at the same time, as this can lead to overdose or increased side effects. If you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma, tell your doctor before taking this medicine. Do not use this medicine during the last three months of pregnancy. If you are breastfeeding, consult your doctor before use. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use it after the expiry date. If your pain does not improve after a few days or gets worse, stop the medicine and consult your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients above 65 years are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Consult a doctor before use and monitor for side effects closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like ibuprofen may interfere with ovulation and are generally avoided during pregnancy, especially in the third trimester. Paracetamol is considered safer but should be used at the lowest effective dose for the shortest time.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but it should be avoided in patients undergoing coronary artery bypass graft (CABG) surgery due to increased risk of cardiovascular events. Consult your surgeon before taking this medicine after any surgery.
🦷 Dental Procedures
This medicine can be effective for dental pain and pain after dental procedures. However, inform your dentist if you are taking this medicine, as it may increase bleeding risk during dental surgery. Do not take it without your dentist's advice if you have a bleeding disorder.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue light to moderate exercise as tolerated. However, if you experience dizziness or fatigue, avoid strenuous activities and driving. If you have muscle or joint pain, gentle stretching and low-impact exercises are recommended. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take regular breaks and maintain good posture. If your pain is well controlled, you can perform daily activities normally.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain or fever does not improve after 3 to 10 days, if you experience side effects such as stomach pain, black stools, or yellowing of eyes, or if you develop any signs of an allergic reaction. Do not stop suddenly if you have been taking it regularly for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney injury, liver damage, and cardiovascular events such as heart attack and stroke. Regular monitoring of kidney and liver function, blood pressure, and blood counts may be required if prolonged use is necessary. It is not recommended for long-term use without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce localized pain and inflammation.
Evidence: Well-establishedMay help with certain types of chronic pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before getting vaccinated. It is generally safe to take this medicine after vaccination for soreness or mild fever, but follow your doctor's advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or doctor's note, especially for international travel. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking the medicine as needed for pain or fever, but do not exceed the maximum daily dose. Check local customs regulations regarding carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It is best taken with food or milk to reduce the risk of stomach upset and bleeding.
A: Do not take more than 3 tablets in 24 hours unless your doctor advises otherwise.
A: It is not recommended during the third trimester. Consult your doctor before taking it during pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for cetafen 400mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
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multigon tabletSun Pharmaceutical Industries Ltd ₹5.33 18.8% CHEAPER
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ibuwin 400 mg/500 mg tabletWings Biotech Ltd ₹5.91 9.9% CHEAPER
-
aryagesic 400mg/500mg tabletAryan Biotech Pvt Ltd ₹6.50 0.9% CHEAPER
-
rumaflam 400mg/500mg tabletOsho Pharma Pvt Ltd ₹6.56 SAME PRICE
-
brugin tabletIatros Pharmaceuticals Pvt Ltd ₹6.57 0.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is completely safe for long-term use.
Fact: Long-term use can cause stomach bleeding, kidney problems, and heart issues. It should be used short-term unless advised by a doctor. - Myth: Taking two tablets at once gives faster relief.
Fact: Taking more than the recommended dose increases the risk of serious side effects without providing better relief. - Myth: It is safe to take with alcohol.
Fact: Alcohol increases the risk of stomach bleeding and liver damage. It should be avoided completely.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen + Paracetamol generic
Brand Alternatives
- Combiflam
- Brufen Plus
- Ibugesic Plus