cetafen 400mg/500mg tablet - Uses, Price, Side Effects & Substitutes
What is cetafen 400mg/500mg tablet used for?
Adiflam Plus 400 mg/500 mg Tablet (Ibuprofen + Paracetamol) is used to treat PAIN ANALGESICS. It contains Ibuprofen (400mg) + Paracetamol (500mg), which Ibuprofen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamo. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ibuprofen + Paracetamol
- Manufacturer: Waksman Selman Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cetafen 400mg/500mg tablet Uses & Benefits
Mild to moderate pain, fever, inflammation (e.g., headache, dental pain, dysmenorrhea, osteoarthritis).
Off-label uses: Patent ductus arteriosus closure (ibuprofen), migraine (paracetamol).
๐ Drug Information
| Generic Name(s) | Ibuprofen + Paracetamol |
| Brand Name | Adiflam Plus 400 mg/500 mg Tablet |
| Manufacturer | Waksman Selman Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ibuprofen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in CNS, reducing pain and fever.
Mechanism Steps
๐ก How to Take cetafen 400mg/500mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cetafen 400mg/500mg tablet
โ Common Side Effects
- Nausea
- Dyspepsia
- Headache
- Dizziness
- Rash
๐จ Serious Side Effects
- GI bleeding
- Renal failure
- Hepatotoxicity
- Cardiovascular events
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Aplastic anemia
- Agranulocytosis
- Pancreatitis
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels |
| Aspirin | Major | Increased GI bleeding risk |
| Other NSAIDs | Major | Additive GI and renal toxicity |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Diuretics | Moderate | Reduced diuretic effect |
| Anticoagulants | Moderate | Increased bleeding risk |
| Corticosteroids | Moderate | Increased GI ulcer risk |
| Antacids | Minor | Reduced absorption of ibuprofen |
| Caffeine | Minor | Additive analgesic effect |
| Cholestyramine | Minor | Reduced absorption of paracetamol |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
- Other NSAIDs
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- Corticosteroids
โน๏ธ Minor Interactions
- Antacids
- Caffeine
- Cholestyramine
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid high-fat meals.
๐ท Alcohol Interaction
Increased risk of GI bleeding and hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active GI bleeding, severe renal/hepatic impairment, third trimester pregnancy, history of asthma with NSAIDs.
๐ Monitoring Parameters
Renal function, hepatic function, blood pressure, signs of GI bleeding.
๐คฑ Lactation Safety
Ibuprofen: Safe in low doses; Paracetamol: Safe.
๐ Overdose Management
Activated charcoal, supportive care; for paracetamol overdose: N-acetylcysteine.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose.