addurso 300 tablet - Ursodeoxycholic Acid (300mg) medicine

addurso 300 tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Addii Biotech Private Limited ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 28, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 28, 2026

What is addurso 300 tablet used for?

Actibile 300 Tablet (Ursodeoxycholic Acid) is used to treat GASTRO INTESTINAL. It contains Ursodeoxycholic Acid (300mg), which Reduces cholesterol saturation in bile and promotes dissolution of cholesterol g. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Ursodeoxycholic Acid
  • Manufacturer: Addii Biotech Private Limited
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š addurso 300 tablet Uses & Benefits

Dissolution of radiolucent cholesterol gallstones, primary biliary cholangitis, primary sclerosing cholangitis.

Off-label uses: Non-alcoholic fatty liver disease, cholestasis of pregnancy, cystic fibrosis liver disease.

๐Ÿ“‹ Drug Information

Generic Name(s)Ursodeoxycholic Acid
Brand NameActibile 300 Tablet
ManufacturerAddii Biotech Private Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassHepatoprotectives
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC) in a dry place.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed from the small intestine after oral administration.
DistributionDistributed into bile and enterohepatic circulation.
Protein Binding70-80%
MetabolismMetabolized in the liver to taurine and glycine conjugates.
Half-Life3.5-5.8 days
ExcretionPrimarily excreted in feces via bile; small amount in urine.
BioavailabilityApproximately 30-60%
Onset of Action1-2 weeks
Peak Plasma Time1-3 hours
Duration of ActionSeveral hours

How It Works

Reduces cholesterol saturation in bile and promotes dissolution of cholesterol gallstones.

Mechanism Steps

1Reduces cholesterol secretion into bile by inhibiting hepatic cholesterol synthesis.
2Decreases intestinal absorption of cholesterol.
3Increases bile flow and promotes dissolution of cholesterol gallstones.

๐Ÿ’ก How to Take addurso 300 tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of addurso 300 tablet

โœ… Common Side Effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Abdominal pain
  • Constipation

๐Ÿšจ Serious Side Effects

  • Severe diarrhea
  • Dehydration
  • Electrolyte imbalance
  • Worsening of liver function

โš ๏ธ Rare Side Effects

  • Allergic reactions
  • Rash
  • Urticaria
  • Biliary sludge
  • Pancreatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Cholestyramine Major Reduces absorption of ursodeoxycholic acid
Colestipol Major Reduces absorption of ursodeoxycholic acid
Aluminum-containing antacids Major Reduces absorption of ursodeoxycholic acid
Ciclosporin Moderate May decrease ciclosporin absorption
Ciprofloxacin Moderate May reduce absorption of ciprofloxacin
Dapsone Moderate May reduce absorption of dapsone
Nitrendipine Moderate May reduce absorption of nitrendipine
Oral contraceptives Minor May reduce efficacy of ursodeoxycholic acid
Clofibrate Minor May reduce efficacy of ursodeoxycholic acid

๐Ÿšจ Major Interactions

  • Cholestyramine
  • Colestipol
  • Aluminum-containing antacids

โšก Moderate Interactions

  • Ciclosporin
  • Ciprofloxacin
  • Dapsone
  • Nitrendipine

โ„น๏ธ Minor Interactions

  • Oral contraceptives
  • Clofibrate

๐Ÿฝ๏ธ Food Interactions

May be taken with food to reduce gastrointestinal discomfort.

๐Ÿท Alcohol Interaction

Avoid alcohol as it may worsen liver function.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to ursodeoxycholic acid, complete biliary obstruction, inflammatory bowel disease.

๐Ÿ“Š Monitoring Parameters

Liver function tests (ALT, AST, ALP, bilirubin), ultrasound for gallstone dissolution.

๐Ÿคฑ Lactation Safety

Excreted in breast milk in small amounts; use with caution.

๐Ÿ’Š Overdose Management

Induce vomiting or gastric lavage; symptomatic treatment.

โฐ Missed Dose

Take as soon as remembered unless almost time for next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 28, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for addurso 300 tablet

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Alternative brands with exact same active ingredient (Ursodeoxycholic Acid (300mg)):

Medical Note: Always consult your doctor before switching medications.

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