adcospas tablet - Paracetamol (325mg) + Pamabrom (25mg) medicine

Adcospas Tablet: Complete Medicine Guide

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🏭 Oaknet Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 27, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term symptomatic relief of PMS symptoms.
Reviewed by
SaathiMed Expert Panel | Oct 27, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes (jaundice)
  • Severe abdominal pain or vomiting blood
  • Blood in stool or black tarry stools
  • Swelling of face, lips, or throat, or difficulty breathing
  • Decreased urine output or swelling in legs
  • Severe headache with vision changes
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is adcospas tablet used for?

This medicine is a combination of Paracetamol and Pamabrom used to relieve PMS symptoms such as bloating, headache, and cramping. It works by reducing pain and promoting mild diuresis.

  • Generic Name: Paracetamol + Pamabrom
  • Manufacturer: Oaknet Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 adcospas tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और पैमाब्रोम का संयोजन है, जिसका उपयोग पीएमएस (प्रीमेंस्ट्रुअल सिंड्रोम) के लक्षणों जैसे पेट फूलना, स्तन में कोमलता, सिरदर्द और मासिक धर्म में ऐंठन को कम करने के लिए किया जाता है। यह दर्द निवारक और हल्के मूत्रवर्धक के रूप में काम करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, पेट में असुविधा, चक्कर आना, नींद आना और बार-बार पेशाब आना शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यकृत की क्षति या एलर्जी प्रतिक्रिया हो सकती है। किसी भी असामान्य लक्षण पर डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें क्योंकि इससे यकृत को नुकसान हो सकता है। इस दवा के साथ शराब न पिएं। यदि आपको यकृत या गुर्दे की समस्या है या आप अन्य पैरासिटामोल युक्त दवाएं ले रहे हैं तो डॉक्टर को बताएं। बिना सलाह के कुछ दिनों से अधिक इसका उपयोग न करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 adcospas tablet Uses & Benefits

[{"condition":"Premenstrual syndrome (PMS) symptom relief","description":"This medicine helps reduce bloating, water retention, breast tenderness, headache, and mild abdominal cramping associated with PMS.","evidence":"Well-established for the combination in short-term symptomatic relief."},{"condition":"Mild to moderate pain","description":"Paracetamol component provides relief from mild to moderate pain such as headache, muscle aches, and menstrual cramps.","evidence":"Well-established for Paracetamol."},{"condition":"Fever","description":"Paracetamol component reduces fever by acting on the hypothalamus.","evidence":"Well-established for Paracetamol."}]

Off-label uses: [{"condition":"Menstrual edema","description":"Sometimes used to reduce fluid retention during menstruation.","evidence":"Limited, based on the diuretic effect of Pamabrom."}]

Primary treatment for: Premenstrual syndrome (PMS)

Also treats: Mild to moderate pain, Fever, Menstrual edema

📋 Drug Information

Generic Name(s)Paracetamol + Pamabrom
Brand NameAdcospas Tablet
ManufacturerOaknet Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassAnalgesic, Antipyretic, Diuretic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture, or as printed on the pack.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Do not exceed the recommended dose; too much Paracetamol can harm the liver.
3
Avoid alcohol completely while taking this medicine.
4
Stay well hydrated, especially because of the diuretic component.
5
Do not take other Paracetamol-containing products simultaneously.
6
Consult your doctor if symptoms persist beyond 7 days or worsen.
7
Report any unusual bleeding, bruising, or yellowing of eyes to your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Bloating and water retention
This medicine is commonly used for PMS-related bloating.
Likely Use
✅
Breast tenderness
This medicine may help relieve breast tenderness associated with PMS.
Likely Use
❌
Severe abdominal pain
This medicine is not for severe pain; seek medical attention.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Pamabrom is also absorbed orally. Food may delay the onset of Paracetamol absorption.
DistributionParacetamol distributes widely into most body tissues, with relatively low protein binding. Pamabrom distribution is not well characterized but is expected to distribute into extracellular fluid.
Protein BindingParacetamol: approximately 10-25% bound to plasma proteins. Pamabrom: Not established from the available information.
MetabolismParacetamol is primarily metabolized in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione. Pamabrom metabolism is not well established.
Half-LifeParacetamol: 2-3 hours in adults with normal liver function. Pamabrom: Not established from the available information.
ExcretionParacetamol metabolites are excreted primarily in urine. Pamabrom is excreted in urine as unchanged drug and metabolites.
BioavailabilityParacetamol: approximately 80-100% after oral administration. Pamabrom: Not established from the available information.
Onset of ActionParacetamol: 30-60 minutes for pain relief. Pamabrom: diuretic effect may begin within 1-2 hours.
Peak Plasma TimeParacetamol: 0.5-2 hours. Pamabrom: Not established from the available information.
Duration of ActionParacetamol: 4-6 hours. Pamabrom: diuretic effect may last 4-6 hours.

How It Works

Paracetamol reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system, primarily through COX enzymes, and possibly by activating descending serotonergic pathways. Pamabrom is a mild diuretic that increases urine output by inhibiting tubular reabsorption of sodium and water, helping to relieve bloating and water retention.

Mechanism Steps

1
Central prostaglandin inhibition: Paracetamol acts in the brain and spinal cord to reduce prostaglandin production, which lowers pain perception and fever.
2
Diuretic action: Pamabrom inhibits sodium and water reabsorption in the kidney tubules, increasing urine output and reducing bloating.
3
Symptom relief: Together, these actions relieve headache, cramping, breast tenderness, and fluid retention associated with PMS.

💡 How to Take adcospas tablet

Strength: Each tablet contains Paracetamol 325 mg and Pamabrom 25 mg.

1Take this medicine by mouth with a full glass of water.
2Take with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take only as needed for symptoms, not more often than every 4-6 hours.
5Do not exceed 6 tablets in 24 hours.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally every 4 to 6 hours as needed for symptoms, not to exceed 6 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the maximum daily dose of Paracetamol 2000 mg from all sources.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to side effects. Use with caution and individualize dose based on renal and hepatic function. Consult a doctor.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be required. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction or avoidance may be necessary. Consult a doctor.
Maximum Daily DoseMaximum 6 tablets in 24 hours, not exceeding Paracetamol 2000 mg per day from all sources.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals or milk
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of adcospas tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset. Consult doctor if persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.
Drowsiness (Uncommon (1-5%))
Rest if needed. Avoid alcohol and other sedatives.
Increased urination (Common (5-10%))
Stay hydrated. This is expected due to the diuretic component.

🚨 Serious Side Effects

Severe liver injury (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services if you experience swelling of face, lips, throat, difficulty breathing, or severe rash.
Blood disorders (e.g., thrombocytopenia) (Very rare (<0.01%))
Report unusual bleeding or bruising to your doctor immediately.

⚠️ Rare Side Effects

Severe skin reactions (e.g., Stevens-Johnson syndrome)
Stop the medicine and seek immediate medical help if you develop a painful rash with blisters or peeling skin.
Kidney problems
Report decreased urine output or swelling to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other Paracetamol products Major
Alcohol Moderate
Carbamazepine Moderate
Phenytoin Moderate
Rifampicin Moderate
Anticholinergics Minor

🚨 Major Interactions

  • Warfarin
  • Other Paracetamol-containing products

⚡ Moderate Interactions

  • Alcohol
  • Carbamazepine, phenytoin, rifampicin

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from Paracetamol and may worsen side effects such as dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Paracetamol, Pamabrom, or any component","Severe liver disease or active liver failure","Severe kidney disease","Patients taking other Paracetamol-containing products"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose of Paracetamol; high doses can cause liver damage.","Avoid alcohol while taking this medicine.","Use with caution in patients with liver or kidney disease.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Consult a doctor if symptoms persist beyond 7 days or worsen.","Not recommended for children under 12 years without medical advice."]

🤱 Lactation Safety

Paracetamol is considered compatible with breastfeeding. Pamabrom may pass into breast milk; consult your doctor before use while breastfeeding.

💊 Overdose Management

Overdose of Paracetamol can cause severe liver damage. Seek immediate medical attention even if you feel well. The antidote N-acetylcysteine may be administered by a healthcare professional. Pamabrom overdose may cause dehydration and electrolyte imbalance; supportive care is required.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as directed by your doctor. Do not exceed the recommended dose because too much Paracetamol can harm the liver. Avoid drinking alcohol while taking this medicine. Inform your doctor if you have liver or kidney problems, or if you are taking other medicines containing Paracetamol. Do not use this medicine for more than a few days without medical advice. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before use.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to side effects such as dizziness and drowsiness. Use with caution and individualize dose based on renal and hepatic function.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Paracetamol is generally considered safe, but Pamabrom safety is not well established.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, especially if you are taking other pain medications or have liver or kidney concerns.

🦷 Dental Procedures

This medicine may be used for mild pain after dental procedures, but consult your dentist or doctor for proper pain management.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce symptom severity.
🥗
Regular low-impact exercise like walking or swimming.
😴
Practice stress-reduction techniques such as yoga or meditation.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep and stay hydrated.

🏋️ Exercise Considerations

This medicine may cause dizziness or drowsiness. Avoid strenuous exercise or operating machinery until you know how it affects you.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce salt intake to minimize bloating.
Stay well hydrated with water.
Limit caffeine and alcohol.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe for office work.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if symptoms persist beyond 7 days, worsen, or if you experience any serious side effects. Do not stop prescribed treatment without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged high-dose Paracetamol can cause liver damage. Regular use of Pamabrom may lead to electrolyte imbalances. Monitor liver and kidney function if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Heat therapy

Applying a heating pad to the lower abdomen can help relieve menstrual cramps.

Evidence: Well-established
Dietary changes

Reducing salt and caffeine may help reduce bloating and breast tenderness.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, continue your regular dosing schedule as advised by your doctor. Check customs regulations for carrying medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 28-year-old woman with monthly PMS symptoms including bloating and headache.
She started taking this medicine as prescribed during her premenstrual phase. She noticed significant relief from bloating and headache within a few hours. She made sure to take it with food to avoid stomach upset and avoided alcohol.
💡 Lesson: Taking this medicine with food and as directed can effectively relieve PMS symptoms without stomach discomfort.
👤 A 35-year-old woman with mild menstrual cramps and water retention.
She used this medicine for a few days each month. She found that it reduced her cramps and bloating, but she experienced increased urination. Her doctor advised her to stay hydrated and not exceed the recommended dose.
💡 Lesson: Increased urination is expected due to the diuretic component; staying hydrated is important.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Paracetamol starts relieving pain within 30-60 minutes, while the diuretic effect of Pamabrom may begin within 1-2 hours.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: Is it safe during pregnancy?

A: Paracetamol is generally considered safe, but Pamabrom safety is not well established. Consult your doctor before use.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for adcospas tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of pain.
    Fact: It is specifically formulated for PMS symptoms and mild pain; it is not for severe pain or chronic conditions without medical advice.
  • Myth: It is safe to take with alcohol.
    Fact: Alcohol increases the risk of liver damage from Paracetamol and should be avoided.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol + Pamabrom combination products

Brand Alternatives

  • Adcospas Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Paracetamol 325 mg + Pamabrom 25 mg","primary_use":"PMS symptoms","route":"Oral"},{"medicine":"Paracetamol alone","composition":"Paracetamol 500 mg","primary_use":"Pain and fever","route":"Oral"},{"medicine":"Ibuprofen + Pamabrom","composition":"Ibuprofen 200 mg + Pamabrom 25 mg","primary_use":"PMS symptoms","route":"Oral"}]

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