adaple 0.1% gel

4.6 (17 reviews)

Adapalene (0.1% w/w)

🏭 Wallace Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is adaple 0.1% gel used for?

Adaferin Gel (Adapalene) is used to treat DERMA. It contains Adapalene (0.1% w/w), which Binds to retinoic acid receptors (RARs), modulating gene expression to normalize. Always consult your doctor before use. Take as prescribed.

Generic Name: Adapalene
Manufacturer: Wallace Pharmaceuticals Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 adaple 0.1% gel Uses & Benefits

Acne vulgaris (comedonal, inflammatory, and mixed acne).

Off-label uses: Photoaging, Keratosis pilaris, Melasma

📋 Drug Information

Generic Name(s)	Adapalene
Brand Name	Adaferin Gel
Manufacturer	Wallace Pharmaceuticals Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Retinoids- Third generation
Route of Administration	Topical
Storage	Store at 20-25°C (68-77°F); protect from light and heat.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionApproximately 2.5% of topically applied adapalene is absorbed through the skin.

DistributionDistributed into skin layers; systemic distribution is minimal due to low absorption.

Protein Binding>99% bound to plasma proteins.

MetabolismMetabolized primarily by cytochrome P450 enzymes, mainly CYP2C9 and CYP3A4.

Half-LifeApproximately 7-10 hours (topical); systemic half-life not well defined.

ExcretionPrimarily excreted in feces (biliary) and to a lesser extent in urine.

BioavailabilityLow systemic bioavailability (<5%) due to minimal percutaneous absorption.

Onset of ActionClinical improvement may be seen within 2-4 weeks of regular use.

Peak Plasma TimeNot applicable for topical use; systemic levels are negligible.

Duration of ActionSustained effect with once-daily application; continuous use required for maintenance.

How It Works

Binds to retinoic acid receptors (RARs), modulating gene expression to normalize follicular keratinization and reduce inflammation.

Mechanism Steps

1Binds to retinoic acid receptors (RAR-β and RAR-γ) in keratinocytes

2Modulates gene expression involved in cell differentiation and proliferation

3Normalizes follicular keratinization, reducing microcomedone formation

💡 How to Take adaple 0.1% gel

Follow your doctor's prescription exactly.

⚠️ Side Effects of adaple 0.1% gel

✅ Common Side Effects

Skin dryness
Erythema
Peeling
Burning sensation
Pruritus

🚨 Serious Side Effects

Severe allergic reaction
Angioedema
Stevens-Johnson syndrome (rare)

⚠️ Rare Side Effects

Hyperpigmentation
Hypopigmentation
Photosensitivity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Other topical retinoids	Major	Increased risk of skin irritation and toxicity
Benzoyl peroxide	Major	Increased skin irritation; use at different times of day
Topical corticosteroids	Moderate	May reduce efficacy of adapalene
Topical antibiotics	Moderate	Possible additive irritation
Sunscreens	Minor	No significant interaction; use as directed
Cosmetics with drying agents	Minor	May increase skin dryness

🚨 Major Interactions

Other topical retinoids
Benzoyl peroxide (concomitant use may cause irritation)

⚡ Moderate Interactions

Topical corticosteroids
Topical antibiotics (e.g., clindamycin)

ℹ️ Minor Interactions

Sunscreens
Cosmetics with drying agents

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction; however, alcohol may increase skin dryness.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to adapalene or any component; pregnancy (category C); eczema; sunburn.

📊 Monitoring Parameters

Skin irritation, dryness, peeling; therapeutic response (reduction in acne lesions).

🤱 Lactation Safety

Not recommended; unknown if excreted in breast milk.

💊 Overdose Management

Topical overdose unlikely; if ingested, treat symptomatically.

⏰ Missed Dose

Apply as soon as remembered; if close to next dose, skip missed dose. Do not double.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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Alternative brands with exact same active ingredient (Adapalene (0.1% w/w)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026