Acvom 10mg/20mg Tablet - Uses, Price, Side Effects
What is acvom 10mg/20mg tablet used for?
Acvom 10mg/20mg Tablet is a combination of Domperidone and Omeprazole used to treat gastroesophageal reflux disease (GERD), acidity, and heartburn. Domperidone helps control nausea and vomiting by increasing stomach motility, while Omeprazole reduces stomach acid production. This dual action provides relief from symptoms like burning sensation and regurgitation.
- Generic Name: Domperidone + Omeprazole
- Manufacturer: Pharma Plus
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ acvom 10mg/20mg tablet Uses & Benefits
Gastroesophageal reflux disease (GERD), dyspepsia, gastroparesis, peptic ulcer disease.
Off-label uses: Nausea and vomiting of various etiologies, migraine-associated gastroparesis.
๐ Drug Information
| Generic Name(s) | Domperidone + Omeprazole |
| Brand Name | Aciloc RD 20 Tablet |
| Manufacturer | Pharma Plus |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone is a dopamine D2 receptor antagonist that enhances gastrointestinal motility; Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by inhibiting H+/K+ ATPase in parietal cells.
Mechanism Steps
๐ก How to Take acvom 10mg/20mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of acvom 10mg/20mg tablet
โ Common Side Effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Flatulence
- Dry mouth
๐จ Serious Side Effects
- QT prolongation
- Torsades de pointes
- Extrapyramidal symptoms
- Gynecomastia
- Hyperprolactinemia
- Interstitial nephritis
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Anaphylaxis
- Agranulocytosis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Clopidogrel | Moderate | Reduced antiplatelet effect |
| Digoxin | Moderate | Increased digoxin levels |
| Methotrexate | Major | Increased methotrexate toxicity |
๐จ Major Interactions
- Ketoconazole
- Itraconazole
- Voriconazole
- Clarithromycin
- Erythromycin
- Ritonavir
- Saquinavir
- Telithromycin
- Nefazodone
- Cobicistat
โก Moderate Interactions
- Warfarin
- Cilostazol
- Methotrexate
- Tacrolimus
- Fluconazole
- Cimetidine
- Digoxin
- Iron salts
- Mycophenolate mofetil
โน๏ธ Minor Interactions
- Sucralfate
- Antacids
- Theophylline
- Caffeine
๐ฝ๏ธ Food Interactions
Omeprazole absorption may be delayed by food; Domperidone should be taken before meals.
๐ท Alcohol Interaction
Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to components, gastrointestinal hemorrhage, mechanical obstruction or perforation, prolactinoma, concurrent use with QT-prolonging drugs.
๐ Monitoring Parameters
ECG for QT interval, renal function, liver function, serum electrolytes, signs of extrapyramidal symptoms.
๐คฑ Lactation Safety
Domperidone is excreted in breast milk; omeprazole is likely excreted. Use with caution.
๐ Overdose Management
Supportive care; ECG monitoring for QT prolongation; activated charcoal if recent ingestion.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next scheduled dose.