acorab dsr capsule - Uses, Price, Side Effects & Substitutes
What is acorab dsr capsule used for?
Acera-D Capsule SR (Domperidone + Rabeprazole) is used to treat GASTRO INTESTINAL. It contains Domperidone (30mg) + Rabeprazole (20mg), which Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and . Always consult your doctor before use. Take as prescribed.
- Generic Name: Domperidone + Rabeprazole
- Manufacturer: Astra Eureka Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ acorab dsr capsule Uses & Benefits
๐ Drug Information
| Generic Name(s) | Domperidone + Rabeprazole |
| Brand Name | Acera-D Capsule SR |
| Manufacturer | Astra Eureka Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Rabeprazole: Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells, reducing gastric acid secretion.
Mechanism Steps
๐ก How to Take acorab dsr capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of acorab dsr capsule
โ Common Side Effects
- Headache
- Diarrhea
- Constipation
- Abdominal pain
- Nausea
- Dry mouth
๐จ Serious Side Effects
- QT prolongation
- Ventricular arrhythmias
- Torsades de pointes
- Gynecomastia
- Galactorrhea
- Liver injury
โ ๏ธ Rare Side Effects
- Extrapyramidal symptoms
- Hyperprolactinemia
- Interstitial nephritis
- Clostridium difficile infection
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased risk of QT prolongation and arrhythmias |
| Warfarin | Moderate | Increased INR and bleeding risk |
| Digoxin | Moderate | Increased digoxin levels |
| Antacids | Minor | Reduced absorption of rabeprazole |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP2C19 inhibitors (e.g., fluconazole)
- QT-prolonging drugs (e.g., amiodarone, moxifloxacin)
โก Moderate Interactions
- Antacids
- Sucralfate
- Digoxin
- Methotrexate
โน๏ธ Minor Interactions
- Caffeine
- Theophylline
๐ฝ๏ธ Food Interactions
Food may delay absorption of domperidone; rabeprazole absorption unaffected by food.
๐ท Alcohol Interaction
Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to domperidone or rabeprazole; gastrointestinal hemorrhage, obstruction, or perforation; prolactinoma; concomitant use with QT-prolonging drugs or strong CYP3A4 inhibitors.
๐ Monitoring Parameters
ECG for QT interval; liver function tests; renal function; serum electrolytes.
๐คฑ Lactation Safety
Domperidone: Excreted in breast milk, may cause adverse effects; Rabeprazole: Excreted in breast mil
๐ Overdose Management
Symptomatic and supportive treatment; gastric lavage; monitoring of ECG for QT prolongation.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.