Accept-XL Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is acnoa 100 mg/50 mg tablet used for?
This medicine is a combination of Aceclofenac and Diacerein used to treat pain and inflammation in osteoarthritis. It works by reducing pain and protecting cartilage. It is taken orally with food, usually twice daily, as prescribed by a doctor.
- Generic Name: Aceclofenac + Diacerein
- Manufacturer: MMC Healthcare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 acnoa 100 mg/50 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिफेनाक और डायसेरिन का संयोजन है, जिसका उपयोग ऑस्टियोआर्थराइटिस (जोड़ों की गठिया) में दर्द, सूजन और जकड़न को कम करने के लिए किया जाता है। यह जोड़ों की उपास्थि (कार्टिलेज) की रक्षा करने में भी मदद करती है। यह मुख्य रूप से घुटने, कूल्हे और हाथ के जोड़ों की गठिया के लिए दी जाती है। इसे भोजन के साथ लेना चाहिए। इस दवा को डॉक्टर की सलाह के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट दर्द, जलन, मतली, दस्त और सिरदर्द शामिल हैं। डायसेरिन के कारण शुरुआत में दस्त हो सकते हैं। गंभीर दुष्प्रभावों में पेट के अल्सर, रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति और एलर्जी प्रतिक्रिया शामिल हैं। यदि काले मल, उल्टी में खून, पेट में तेज दर्द, आंखों या त्वचा का पीलापन, पेशाब में कमी, या चेहरे, होंठ या गले में सूजन हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। गोली को चबाएं नहीं, पूरा निगलें। इस दवा के साथ शराब न लें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। डॉक्टर की सलाह के बिना अन्य दर्द निवारक दवाएं न लें। यदि आपको गुर्दे या यकृत की समस्या है, तो डॉक्टर को बताएं। बिना सलाह के लंबे समय तक इस दवा का उपयोग न करें। बच्चों की पहुंच से दूर रखें।
💊 acnoa 100 mg/50 mg tablet Uses & Benefits
[{"condition":"Osteoarthritis of the knee","description":"Reduces pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness, and improves joint mobility in knee osteoarthritis.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hip","description":"Helps alleviate pain and improve function in hip osteoarthritis.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hand","description":"May reduce pain and improve hand function in hand osteoarthritis.","evidence":"Moderate"},{"condition":"Rheumatoid arthritis","description":"Sometimes used for short-term symptom relief in rheumatoid arthritis, but not as a first-line disease-modifying drug.","evidence":"Limited"},{"condition":"Ankylosing spondylitis","description":"May be used to relieve pain and stiffness in ankylosing spondylitis.","evidence":"Limited"}]
Off-label uses: [{"condition":"Acute gouty arthritis","description":"Occasionally used for short-term pain relief in acute gout attacks, but not a standard treatment.","evidence":"Limited"},{"condition":"Post-operative pain","description":"May be used off-label for short-term management of mild to moderate post-operative pain.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis
Also treats: Rheumatoid arthritis, Ankylosing spondylitis, Chronic low back pain
📋 Drug Information
| Generic Name(s) | Aceclofenac + Diacerein |
| Brand Name | Accept-XL Tablet |
| Manufacturer | MMC Healthcare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Anthraquinone derivative |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Diacerein is an anthraquinone derivative that inhibits interleukin-1 beta (IL-1β), a key cytokine involved in cartilage degradation and joint inflammation. By inhibiting IL-1β, diacerein helps to reduce cartilage breakdown and may stimulate cartilage repair. Together, these actions provide both rapid symptomatic relief (from aceclofenac) and slower, disease-modifying effects on joint cartilage (from diacerein).
Mechanism Steps
💡 How to Take acnoa 100 mg/50 mg tablet
Strength: Tablet containing Aceclofenac 100 mg and Diacerein 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally twice daily, preferably with meals. However, the exact dose and duration of treatment must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, kidney function, and liver function. Do not self-adjust the dose. Take the tablet whole with a glass of water. Do not crush or chew. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. The dose may need to be adjusted by a clinician based on kidney and liver function. Use with caution and monitor closely. |
| Renal Impairment | Patients with mild to moderate kidney impairment may require dose adjustment. This medicine is contraindicated in severe kidney disease (creatinine clearance <30 mL/min). Consult a doctor for personalized dosing. |
| Hepatic Impairment | Patients with mild to moderate liver impairment should use this medicine with caution. It is contraindicated in severe liver disease. Dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet twice daily (total 200 mg aceclofenac and 100 mg diacerein). Do not exceed this dose unless directed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of acnoa 100 mg/50 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| SSRIs | Moderate | |
| Oral hypoglycemics | Moderate | |
| Cyclosporine | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- Antihypertensives (ACE inhibitors, ARBs, diuretics)
- SSRIs
- Oral hypoglycemics
- Cyclosporine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both aceclofenac and diacerein can irritate the stomach lining, and alcohol increases this risk, potentially leading to ulcers or bleeding. Alcohol can also increase the risk of liver damage. It is best to abstain from alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active or history of peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe kidney disease (e.g., creatinine clearance
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not take other NSAIDs or pain relievers without consulting your doctor.","Use with caution in elderly patients due to increased risk of side effects.","Monitor kidney and liver function during long-term use.","Stop the medicine and consult your doctor if you experience signs of gastrointestinal bleeding (black stools, vomiting blood).","Inform your doctor if you have a history of heart disease, kidney disease, or liver disease.","Do not use for more than the recommended duration without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether aceclofenac and diacerein pass into breast milk. Due to the lack of data, this medicine is not recommended during breastfeeding. Consult your doctor to discuss alternative options.
💊 Overdose Management
Overdose of this medicine may cause severe stomach pain, nausea, vomiting, headache, dizziness, and in severe cases, gastrointestinal bleeding, kidney failure, or liver damage. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be given if the patient presents early. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine with food or milk to reduce stomach upset. Do not crush or chew the tablet; swallow it whole with a glass of water. Avoid alcohol while taking this medicine because it can increase the risk of stomach bleeding. Do not take other pain relievers or NSAIDs without consulting your doctor. If you have kidney or liver problems, your doctor may need to adjust the dose or monitor you more closely. Do not use this medicine for more than the recommended duration without medical advice. Keep out of reach of children. Store at room temperature away from moisture and direct sunlight. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events with NSAIDs. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid concomitant use with other NSAIDs or blood thinners.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like aceclofenac may affect ovulation and are not recommended during pregnancy, especially in the third trimester. Diacerein is also not recommended. Discuss alternative pain management options.
🏥 Post-Surgery Considerations
After surgery, the use of this medicine should be discussed with your surgeon. NSAIDs may increase the risk of bleeding and can interfere with bone healing. Do not take this medicine post-surgery without medical advice.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. NSAIDs can increase bleeding risk during dental surgery. Your dentist may advise you to stop the medicine temporarily or take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While exercise is beneficial for osteoarthritis, avoid high-impact activities that can worsen joint pain. Consult a physiotherapist for a tailored exercise plan. If you experience increased pain or swelling after exercise, rest and apply ice. Do not overexert yourself.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Most people can continue their daily activities, but listen to your body and rest if needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as gastrointestinal bleeding, severe allergic reaction, or kidney problems, stop immediately and seek medical help. Your doctor will advise on the appropriate duration of treatment based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal ulcers, bleeding, kidney problems, and cardiovascular events. Regular monitoring of kidney and liver function is advised. Diacerein may have a protective effect on cartilage, potentially slowing disease progression. However, the combination should be used at the lowest effective dose for the shortest duration necessary. Periodic reassessment by a doctor is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Strengthening exercises and stretching can improve joint function and reduce pain.
Evidence: Well-establishedLosing excess weight reduces stress on weight-bearing joints like knees and hips.
Evidence: Well-establishedMay help reduce pain in some patients with osteoarthritis.
Evidence: ModerateSome evidence suggests they may help with joint health, but results are mixed.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription in case you need to show it at customs or to a local doctor. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking the medicine at the same intervals as prescribed; you may need to adjust the timing gradually. Always pack enough supply for your entire trip, plus extra in case of delays. Do not leave it in a hot car or checked luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Aceclofenac provides pain relief within 30-60 minutes, but diacerein takes 2-4 weeks to show full effects on joint function.
A: No, it should be taken with food or milk to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor for alternative options.
A: Do not stop without consulting your doctor. Some benefits, like cartilage protection, require continued use. Your doctor will advise on duration.
🤔 Common Patient Concerns
🔄 Substitutes for acnoa 100 mg/50 mg tablet
View AllAlternative brands with exact same active ingredient:
-
leecrina tabletLeeford Healthcare Ltd ₹33.05 56.8% CHEAPER
-
diatril ace 100mg/50mg tabletWerke Healthcare ₹73.13 4.4% CHEAPER
-
dica tabletLark Laboratories Ltd ₹88.39 15.5% COSTLIER
-
cartiflex 100 mg/50 mg tabletVilco Laboratories Pvt Ltd ₹89.06 16.4% COSTLIER
-
ortholix ac tabletStrides shasun Ltd ₹92.81 21.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure osteoarthritis completely.
Fact: This medicine helps manage symptoms and may slow cartilage damage, but it does not cure osteoarthritis. Lifestyle changes and other treatments are also important. - Myth: It is safe to take this medicine without a prescription.
Fact: This is a prescription medicine. It should only be taken under medical supervision due to potential serious side effects. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: Do not stop without consulting your doctor. Some effects, like cartilage protection, require continued use. Your doctor will advise on duration. - Myth: This medicine is safe to take with other painkillers.
Fact: Taking other NSAIDs or painkillers with this medicine can increase the risk of side effects. Always consult your doctor before combining.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac 100 mg + Diacerein 50 mg tablet (generic)
Brand Alternatives
- Accept-XL Tablet