Aceliv D 100mg/50mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
- Severe skin rash with blisters
If experiencing severe symptoms, call emergency services immediately.
What is diatril ace 100mg/50mg tablet used for?
This medicine is a combination of Aceclofenac and Diacerein used to treat pain and inflammation in osteoarthritis. It works by reducing pain and protecting cartilage. It is taken orally twice daily with food, as prescribed by a doctor.
- Generic Name: Aceclofenac (100mg) + Diacerein (50mg)
- Manufacturer: Werke Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 diatril ace 100mg/50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटोक्लोफेनाक और डायसेरिन का संयोजन है, जिसका उपयोग ऑस्टियोआर्थराइटिस (जोड़ों की गठिया) में दर्द, सूजन और अकड़न को कम करने के लिए किया जाता है। यह जोड़ों की उपास्थि (कार्टिलेज) को नुकसान से बचाने में भी मदद करती है। यह दवा दर्द निवारक और सूजन कम करने वाली श्रेणी में आती है। इसे डॉक्टर के परामर्श से ही लेना चाहिए। आमतौर पर इसे भोजन के साथ दिन में दो बार लिया जाता है। इस दवा को बिना डॉक्टर की सलाह के नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट दर्द, जी मिचलाना, अपच, दस्त, सिरदर्द और चक्कर आना शामिल हैं। कुछ लोगों को त्वचा पर चकत्ते या खुजली भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में रक्तस्राव, अल्सर, गुर्दे या यकृत की समस्या हो सकती है। यदि आपको काला मल, खून की उल्टी, तेज पेट दर्द, आंखों या त्वचा का पीलापन, या पेशाब कम आना जैसे लक्षण दिखें, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। निर्धारित खुराक से अधिक न लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ जाता है। बिना डॉक्टर की सलाह के अन्य दर्द निवारक दवाएं न लें। यदि आपको पेट के अल्सर, गुर्दे या यकृत की बीमारी, हृदय रोग या अस्थमा है, तो डॉक्टर को बताएं। गर्भावस्था और स्तनपान के दौरान इस दवा का सेवन न करें। यदि आपको चक्कर आते हैं तो वाहन चलाने या मशीन चलाने से बचें।
💊 diatril ace 100mg/50mg tablet Uses & Benefits
[{"condition":"Osteoarthritis of the knee","description":"Reduces pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness, and improves joint mobility in knee osteoarthritis.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hip","description":"Provides symptomatic relief and may slow cartilage degeneration in hip osteoarthritis.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hand","description":"Helps alleviate pain and improve hand function in patients with hand osteoarthritis.","evidence":"Moderate"},{"condition":"Rheumatoid arthritis","description":"May be used as an adjunct for pain relief, but not as a primary disease-modifying therapy.","evidence":"Limited"},{"condition":"Ankylosing spondylitis","description":"Provides symptomatic relief of pain and stiffness; not a first-line treatment.","evidence":"Limited"}]
Off-label uses: [{"condition":"Acute gouty arthritis","description":"Sometimes used for short-term pain relief in acute gout flares, but not a standard first-line option.","evidence":"Limited"},{"condition":"Post-operative pain","description":"Occasionally prescribed for short-term post-surgical pain management, but not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis
Also treats: Rheumatoid arthritis, Ankylosing spondylitis, Chronic joint pain
📋 Drug Information
| Generic Name(s) | Aceclofenac (100mg) + Diacerein (50mg) |
| Brand Name | diatril ace 100mg/50mg tablet |
| Manufacturer | Werke Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the production of prostaglandins which are mediators of pain and inflammation. Diacerein is an anthraquinone derivative that inhibits interleukin-1 beta (IL-1β) and other pro-inflammatory cytokines, and also stimulates the production of transforming growth factor-beta (TGF-β), which promotes cartilage matrix synthesis. Together, they provide rapid symptomatic relief and potentially slow structural progression of osteoarthritis.
Mechanism Steps
💡 How to Take diatril ace 100mg/50mg tablet
Strength: Each tablet contains Aceclofenac 100 mg and Diacerein 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally twice daily, preferably with meals. However, the exact dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to treatment. Do not self-adjust the dose. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more susceptible to the side effects of this medicine, especially gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution and lower doses may be considered. Regular monitoring of kidney and liver function is advised. Dose must be individualized by a qualified clinician. |
| Renal Impairment | This medicine should be used with caution in patients with kidney impairment. In severe kidney impairment (creatinine clearance <30 mL/min), it is contraindicated. For mild to moderate impairment, dose reduction or alternative therapy may be necessary. Consult a nephrologist or your doctor for individualized dosing. |
| Hepatic Impairment | This medicine should be used with caution in patients with liver impairment. In severe liver disease, it is contraindicated. For mild to moderate impairment, dose reduction may be required. Regular monitoring of liver function is advised. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet twice daily (Aceclofenac 200 mg and Diacerein 100 mg per day). Do not exceed this dose without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of diatril ace 100mg/50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| SSRIs | Moderate | |
| Corticosteroids | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs (e.g., ibuprofen, naproxen, aspirin)
- Corticosteroids
- Methotrexate
- Lithium
- ACE inhibitors and angiotensin receptor blockers (ARBs)
- Diuretics (e.g., furosemide, hydrochlorothiazide)
⚡ Moderate Interactions
- Antihypertensives (beta-blockers, calcium channel blockers)
- SSRIs (e.g., fluoxetine, sertraline)
- Oral hypoglycemics (e.g., metformin, sulfonylureas)
- Phenytoin
- Cyclosporine
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Concurrent use increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity. It may also enhance the central nervous system effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to Aceclofenac, Diacerein, or any component of the formulation","Active or history of recurrent peptic ulcer or gastrointestinal bleeding","Severe heart failure (NYHA class III-IV)","Severe kidney impairment (creatinine clearance
⚠️ Warnings & Precautions
["Take with food or milk to minimize gastrointestinal irritation.","Avoid alcohol consumption as it increases the risk of stomach bleeding and liver toxicity.","Do not use concurrently with other NSAIDs or salicylates.","Use with caution in elderly patients due to increased risk of side effects.","Monitor kidney and liver function regularly during long-term therapy.","May impair ability to drive or operate machinery if dizziness occurs.","Inform your doctor if you have a history of heart disease, hypertension, or diabetes.","Stop the medicine and consult your doctor if you experience signs of allergic reaction.","Do not use for more than the recommended duration without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding as both Aceclofenac and Diacerein may pass into breast milk and could harm the infant. Consult your doctor for alternative treatments if you are breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause severe gastrointestinal symptoms, kidney impairment, liver toxicity, and central nervous system effects. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs, kidney and liver function, and provide supportive care as needed.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine with food or milk to reduce stomach upset. Do not exceed the prescribed dose. Avoid alcohol while taking this medicine as it increases the risk of stomach bleeding. Do not take other painkillers or NSAIDs without consulting your doctor. If you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma, inform your doctor before starting this medicine. Use effective contraception during treatment and avoid pregnancy. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Keep all follow-up appointments and get regular blood tests if advised. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution, at the lowest effective dose, and monitor kidney and liver function regularly. Avoid in frail elderly patients unless clearly necessary.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. If you are trying to conceive, consult your doctor for alternative treatments. NSAIDs may interfere with ovulation and are associated with risks to the fetus.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain relief in some cases, but it can increase bleeding risk and impair bone healing. Consult your surgeon before taking it after surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. Your dentist may advise you to stop it temporarily before surgery.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can exercise, but avoid high-impact activities that may worsen joint pain. Consult your doctor or physiotherapist for a suitable exercise plan. If you experience dizziness, avoid activities that require balance.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating heavy machinery. Otherwise, it does not significantly impact daily activities. Take it with food to prevent stomach upset that could interfere with work.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like gastrointestinal bleeding, allergic reactions, or kidney problems, stop immediately and seek medical attention. Your doctor will decide when to stop based on your condition and response to treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of kidney and liver function, blood pressure, and complete blood count is advised. It should be used at the lowest effective dose for the shortest duration necessary. Consult your doctor for periodic reviews.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedReduces joint stress and improves symptoms in overweight patients with osteoarthritis.
Evidence: Well-establishedMay provide pain relief in some patients with osteoarthritis.
Evidence: ModerateSometimes used for osteoarthritis, but evidence is mixed.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue taking it as prescribed, but consult your doctor if you need to adjust the timing. Keep it in your carry-on luggage to avoid loss. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Aceclofenac provides pain relief within 30-60 minutes, while Diacerein's effects on cartilage may take several weeks to become noticeable.
A: No, it should be taken with food or milk to reduce the risk of stomach upset and ulcers.
A: No, alcohol should be strictly avoided as it increases the risk of gastrointestinal bleeding and liver toxicity.
A: Do not stop without consulting your doctor. Abrupt discontinuation may worsen symptoms. Your doctor will advise on the duration of treatment.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for diatril ace 100mg/50mg tablet
View AllAlternative brands with exact same active ingredient:
-
leecrina tabletLeeford Healthcare Ltd ₹33.05 54.8% CHEAPER
-
acnoa 100 mg/50 mg tabletMMC Healthcare Ltd ₹76.53 4.6% COSTLIER
-
dica tabletLark Laboratories Ltd ₹88.39 20.9% COSTLIER
-
cartiflex 100 mg/50 mg tabletVilco Laboratories Pvt Ltd ₹89.06 21.8% COSTLIER
-
ortholix ac tabletStrides shasun Ltd ₹92.81 26.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure osteoarthritis completely.
Fact: This medicine provides symptomatic relief and may slow cartilage damage, but it does not cure osteoarthritis. Lifestyle modifications and other treatments are also important. - Myth: It is safe to take this medicine without a prescription.
Fact: This is a prescription medicine. Self-medication can lead to serious side effects. Always consult a doctor before use. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce the risk of stomach upset and ulcers. - Myth: More tablets mean faster relief.
Fact: Taking more than the prescribed dose can cause serious harm. Always follow the prescribed dose.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac + Diacerein
Brand Alternatives
- Aceliv D 100mg/50mg Tablet