Anal 100mg/2mg Tablet MR: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Fainting or severe dizziness
- Slow or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is aclomex 100mg/2mg capsule used for?
This medicine is a combination of nimesulide (an NSAID) and tizanidine (a muscle relaxant) used for short-term relief of acute musculoskeletal pain and muscle spasm. It is taken orally, usually two to three times daily with food, for a maximum of 5-7 days. It can cause drowsiness, dizziness, and stomach upset, and should be avoided in pregnancy, liver or kidney disease, and with alcohol.
- Generic Name: Nimesulide + Tizanidine
- Manufacturer: Shiwalic Formulations Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 aclomex 100mg/2mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और टिज़ानिडीन का संयोजन है, जिसका उपयोग मांसपेशियों में ऐंठन और दर्द के अल्पकालिक उपचार के लिए किया जाता है। यह पीठ दर्द, गर्दन में दर्द, और चोट के कारण होने वाली मांसपेशियों की ऐंठन में राहत देती है। यह दवा सूजन और दर्द को कम करने के साथ-साथ मांसपेशियों को आराम देती है। इसे डॉक्टर के निर्देशानुसार ही लें और 5-7 दिनों से अधिक न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, थकान, जी मिचलाना, पेट में परेशानी और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या, और गंभीर एलर्जी प्रतिक्रिया हो सकती है। यदि आपको काला मल, उल्टी में खून, त्वचा या आँखों का पीलापन, या साँस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन बिल्कुल न करें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएँ और मशीनरी न चलाएँ। बैठने या लेटने से उठते समय धीरे-धीरे उठें ताकि चक्कर न आए। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
💊 aclomex 100mg/2mg capsule Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"This medicine provides short-term relief of pain and spasm in conditions such as acute low back pain, neck pain, and myofascial pain syndrome.","evidence":"Well-established for short-term use"},{"condition":"Post-traumatic muscle spasm","description":"Used to relieve muscle spasm and pain following injuries such as strains, sprains, and contusions.","evidence":"Commonly used in clinical practice"},{"condition":"Post-operative muscle spasm","description":"May be prescribed for a short duration after surgery to reduce muscle spasm and associated pain.","evidence":"Limited to short-term use"},{"condition":"Tension headache with muscle spasm","description":"Sometimes used when tension headache is accompanied by significant neck and shoulder muscle spasm.","evidence":"Limited evidence"}]
Off-label uses: [{"condition":"Fibromyalgia pain","description":"Occasionally prescribed off-label for pain and muscle spasm in fibromyalgia, but evidence is limited and risks may outweigh benefits.","evidence":"Limited"},{"condition":"Temporomandibular joint disorder","description":"May be used off-label for short-term relief of jaw muscle spasm and pain, but not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Acute musculoskeletal pain with muscle spasm
Also treats: Low back pain, Neck pain, Myofascial pain syndrome, Post-traumatic muscle spasm, Post-operative muscle spasm
📋 Drug Information
| Generic Name(s) | Nimesulide + Tizanidine |
| Brand Name | Anal 100mg/2mg Tablet MR |
| Manufacturer | Shiwalic Formulations Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Muscle Relaxant |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container, tightly closed. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a nonsteroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins that mediate pain, inflammation, and fever. Tizanidine is a centrally acting alpha-2 adrenergic agonist that reduces the release of excitatory neurotransmitters from spinal interneurons, thereby decreasing muscle tone and spasm. Together, they address both the inflammatory pain component and the muscle spasm component of acute musculoskeletal conditions.
Mechanism Steps
💡 How to Take aclomex 100mg/2mg capsule
Strength: Each tablet contains nimesulide 100 mg and tizanidine 2 mg. It is an immediate-release tablet for oral administration.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, as prescribed by your doctor. The dose and duration depend on the condition being treated, your age, weight, kidney and liver function, and response to therapy. Do not exceed the recommended dose. This medicine is intended for short-term use only. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of this medicine, especially drowsiness, dizziness, and low blood pressure. The dose may need to be reduced, and kidney and liver function should be monitored. Use with caution and under medical supervision. |
| Renal Impairment | In patients with mild to moderate renal impairment, the dose may need to be reduced and kidney function monitored. This medicine is contraindicated in severe renal impairment (creatinine clearance <30 mL/min). Consult your doctor for dose adjustment. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, the dose may need to be reduced and liver function monitored. This medicine is contraindicated in severe hepatic impairment. Consult your doctor for dose adjustment. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (300 mg nimesulide and 6 mg tizanidine) per day, but the exact maximum should be determined by your doctor based on your condition and tolerance. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of aclomex 100mg/2mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Fluvoxamine | Major | |
| Ciprofloxacin | Major | |
| Warfarin | Major | |
| Antihypertensives | Major | |
| Other NSAIDs | Major | |
| CNS depressants | Major | |
| Diuretics | Moderate | |
| ACE inhibitors | Moderate | |
| Lithium | Moderate | |
| Methotrexate | Moderate |
🚨 Major Interactions
- CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- Antihypertensives
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
⚡ Moderate Interactions
- Diuretics
- ACE inhibitors and ARBs
- Lithium
- Methotrexate
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the sedative effects of tizanidine and the risk of gastrointestinal bleeding and liver toxicity from nimesulide. It can also cause severe drowsiness, dizziness, and impaired judgment, making driving or operating machinery dangerous.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, tizanidine, or any component of the formulation","Active peptic ulcer disease or history of recurrent ulcers","Severe liver impairment","Severe kidney impairment (creatinine clearance
⚠️ Warnings & Precautions
["This medicine should be used for the shortest duration possible to minimize the risk of serious side effects.","Do not exceed the recommended dose or duration of treatment.","Avoid alcohol and other CNS depressants while taking this medicine.","Do not drive or operate machinery until you know how this medicine affects you.","Rise slowly from sitting or lying positions to prevent dizziness or fainting.","Inform your doctor if you have a history of stomach ulcers, liver disease, kidney disease, high blood pressure, or heart problems.","Report any signs of gastrointestinal bleeding (black stools, vomiting blood) or liver injury (yellowing of skin or eyes) immediately.","Use with caution in elderly patients, who are more susceptible to side effects.","Do not use this medicine for fever or minor aches without consulting a doctor.","Keep out of reach of children."]
🤱 Lactation Safety
Not established from the available information. Nimesulide and tizanidine may pass into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, dizziness, nausea, vomiting, abdominal pain, slow heart rate, low blood pressure, and liver or kidney damage. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including gastric lavage if within 1-2 hours of ingestion, monitoring of vital signs, and liver and kidney function tests. There is no specific antidote. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take the tablet with food or milk to reduce the chance of stomach upset. Avoid alcohol completely while taking this medicine, as it can increase drowsiness and the risk of liver problems. Do not drive or operate heavy machinery until you know how this medicine affects you. Rise slowly from a sitting or lying position to prevent dizziness or fainting due to low blood pressure. Inform your doctor if you have a history of stomach ulcers, liver disease, kidney disease, high blood pressure, or heart problems. Do not use this medicine if you are pregnant, especially in the third trimester, or if you are breastfeeding without consulting your doctor. Keep all follow-up appointments and report any unusual symptoms such as black stools, vomiting blood, severe abdominal pain, yellowing of the skin or eyes, or decreased urine output. Store this medicine at room temperature, away from moisture and direct sunlight, and keep it out of reach of children. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of side effects from this medicine, including drowsiness, dizziness, hypotension, gastrointestinal bleeding, and kidney impairment. The dose should be started at the lowest effective level and adjusted carefully. Regular monitoring of blood pressure, kidney function, and liver function is recommended. Avoid long-term use and consider alternative treatments with a better safety profile.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for use during pregnancy or when planning pregnancy. Nimesulide may interfere with ovulation and increase the risk of miscarriage or fetal harm, especially in the third trimester. Tizanidine may also pose risks to the fetus. If you are planning pregnancy, consult your doctor to discuss safer alternatives for pain and muscle spasm. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
This medicine may be prescribed for short-term relief of post-operative muscle spasm and pain. However, it should be used with caution after surgery due to the risk of bleeding, kidney impairment, and interactions with other medications. Inform your surgeon and anesthesiologist that you are taking this medicine. Do not use it for prolonged periods after surgery without medical supervision.
🦷 Dental Procedures
If you are scheduled for dental procedures, inform your dentist that you are taking this medicine. Nimesulide can increase bleeding risk, and tizanidine can cause drowsiness and dry mouth. Your dentist may advise you to stop the medicine temporarily before the procedure or adjust your dose. Do not stop the medicine without consulting your prescribing doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience drowsiness and dizziness, which can affect your coordination and balance. Avoid high-impact or strenuous exercises until you know how the medicine affects you. Gentle stretching and low-impact activities may be beneficial, but consult your doctor or physiotherapist before starting any exercise program. Do not exercise if you feel dizzy or faint.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and low blood pressure, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid driving or operating heavy machinery until you know how the medicine affects you. Inform your employer if your job involves such activities. Take frequent breaks if you have a desk job, and practice good ergonomics to prevent muscle strain.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience any serious side effects such as black stools, vomiting blood, severe abdominal pain, yellowing of skin or eyes, decreased urine output, severe dizziness, fainting, or signs of an allergic reaction. Do not stop the medicine abruptly without consulting your doctor if you have been taking it for more than a few days, as rebound symptoms may occur. Generally, this medicine is prescribed for short-term use, and you should stop after the prescribed duration unless your doctor advises otherwise.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects. Prolonged use of nimesulide can lead to liver injury, kidney impairment, gastrointestinal ulcers, and bleeding. Tizanidine can cause tolerance, dependence, and persistent drowsiness. If long-term use is unavoidable, regular monitoring of liver and kidney function, blood pressure, and blood counts is essential. Consult your doctor regularly to reassess the need for continued treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and muscle spasm, improving strength and flexibility.
Evidence: Well-establishedApplying heat or cold packs can help relieve muscle spasm and pain.
Evidence: Commonly usedMay provide relief for some patients with musculoskeletal pain.
Evidence: LimitedRelaxation techniques, biofeedback, and meditation can help manage pain and stress.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are taking this medicine. It is generally safe to receive vaccines while on this medicine, but your doctor will advise based on your overall health.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture and direct sunlight. If crossing time zones, continue taking the medicine at the same intervals as prescribed, but consult your doctor for specific advice. Check the customs regulations of your destination country regarding prescription medicines. Do not share this medicine with others.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain and muscle spasm within 30 to 60 minutes after taking it, but the full effect may take a few hours. It is taken two to three times daily as prescribed.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset and gastrointestinal irritation.
A: Avoid alcohol, driving, and operating heavy machinery until you know how the medicine affects you. Also avoid taking other NSAIDs or CNS depressants without consulting your doctor.
A: This medicine is intended for short-term use only, usually not more than 5 to 7 days. Prolonged use increases the risk of liver, kidney, and gastrointestinal problems. Consult your doctor if symptoms persist.
A: Elderly patients are more sensitive to the side effects, especially drowsiness, dizziness, and low blood pressure. The dose may need to be reduced, and close monitoring is required.
🤔 Common Patient Concerns
🔄 Substitutes for aclomex 100mg/2mg capsule
View AllAlternative brands with exact same active ingredient:
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nisul mr tabletIntas Pharmaceuticals Ltd ₹5.63 88.9% CHEAPER
-
Tromazine 100 mg/2 mg TabletPsychotropics India Ltd ₹6.31 87.5% CHEAPER
-
neulab tz tabletLaborate Pharmaceuticals India Ltd ₹20.00 60.5% CHEAPER
-
Naba T TabletMonokem Labs ₹22.50 55.6% CHEAPER
-
nimeson tn 100 mg/2 mg tabletUnison Pharmaceuticals Pvt Ltd ₹24.19 52.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is intended for short-term use only. Prolonged use increases the risk of liver, kidney, and gastrointestinal problems. - Myth: It is okay to drink alcohol while taking this medicine.
Fact: Alcohol should be completely avoided as it increases drowsiness, liver toxicity, and bleeding risk. - Myth: This medicine can be taken for any type of pain.
Fact: It is specifically for musculoskeletal pain with muscle spasm. It is not a general painkiller for all conditions. - Myth: If I feel better, I can stop the medicine immediately.
Fact: You should follow your doctor's instructions. Stopping abruptly may cause rebound symptoms, but generally it is safe to stop after short-term use.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Tizanidine combination (generic)
Brand Alternatives
- Anal 100mg/2mg Tablet MR