aclomex 100mg/2mg capsule
What is aclomex 100mg/2mg capsule used for?
Anal 100mg/2mg Tablet MR (Nimesulide + Tizanidine) is used to treat PAIN ANALGESICS. It contains Nimesulide (100mg) + Tizanidine (2mg), which Nimesulide: Selective COX-2 inhibition reducing prostaglandin synthesis; Tizanid. Always consult your doctor before use. Take as prescribed.
- Generic Name: Nimesulide + Tizanidine
- Manufacturer: Shiwalic Formulations Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ aclomex 100mg/2mg capsule Uses & Benefits
Acute musculoskeletal pain, Low back pain, Spasticity-associated pain
Off-label uses: Dysmenorrhea, Osteoarthritis pain
๐ Drug Information
| Generic Name(s) | Nimesulide + Tizanidine |
| Brand Name | Anal 100mg/2mg Tablet MR |
| Manufacturer | Shiwalic Formulations Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Muscle Relaxant |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Nimesulide: Selective COX-2 inhibition reducing prostaglandin synthesis; Tizanidine: Alpha-2 adrenergic agonist reducing spasticity
Mechanism Steps
๐ก How to Take aclomex 100mg/2mg capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of aclomex 100mg/2mg capsule
โ Common Side Effects
- Nausea
- Dizziness
- Drowsiness
- Dry mouth
- Heartburn
๐จ Serious Side Effects
- Hepatotoxicity
- GI bleeding
- Severe hypotension
- Bradycardia
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Aplastic anemia
- Hallucinations
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Fluvoxamine | Major | Increased tizanidine levels and hypotension |
| Other NSAIDs | Major | Additive GI toxicity |
| Antihypertensives | Major | Enhanced hypotensive effect |
| Lithium | Moderate | Increased lithium levels |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Diuretics | Moderate | Reduced diuretic efficacy |
| ACE inhibitors | Moderate | Increased risk of renal impairment |
| Antacids | Minor | Reduced nimesulide absorption |
| Corticosteroids | Minor | Additive GI irritation |
๐จ Major Interactions
- Warfarin
- CYP1A2 inhibitors (e.g., fluvoxamine)
- Other NSAIDs
- Antihypertensives
โก Moderate Interactions
- Lithium
- Methotrexate
- Diuretics
- ACE inhibitors
โน๏ธ Minor Interactions
- Antacids
- Corticosteroids
๐ฝ๏ธ Food Interactions
Food delays absorption of nimesulide, High-fat meal increases tizanidine absorption
๐ท Alcohol Interaction
Increased risk of hepatotoxicity and CNS depression
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, Active peptic ulcer, Severe hepatic impairment, Severe renal impairment, Pregnancy (third trimester), Concurrent use with CYP1A2 inhibitors
๐ Monitoring Parameters
Liver function tests, Renal function, Blood pressure, CNS depression
๐คฑ Lactation Safety
Not recommended; nimesulide excreted in milk, tizanidine unknown
๐ Overdose Management
Symptomatic and supportive; gastric lavage, activated charcoal; monitor liver function, BP, CNS
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Found this to be a helpful product. Good results.
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.
Found this to be a helpful product. Good results.
This medicine was effective for me. I followed the doctor's advice.