acistal 20mg tablet - Rabeprazole (20mg) medicine

acistal 20mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Torrent Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is acistal 20mg tablet used for?

Acera 20 Capsule (Rabeprazole) is used to treat GASTRO INTESTINAL. It contains Rabeprazole (20mg), which Suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system a. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Rabeprazole
  • Manufacturer: Torrent Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š acistal 20mg tablet Uses & Benefits

Gastroesophageal reflux disease (GERD), erosive esophagitis, Zollinger-Ellison syndrome, Helicobacter pylori eradication (combination therapy), duodenal ulcer, gastric ulcer.

Off-label uses: Stress ulcer prophylaxis, dyspepsia, prevention of NSAID-induced ulcers.

๐Ÿ“‹ Drug Information

Generic Name(s)Rabeprazole
Brand NameAcera 20 Capsule
ManufacturerTorrent Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProton pump inhibitors
Route of AdministrationOral.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from moisture and light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; peak plasma concentration achieved in 2-4 hours.
DistributionVolume of distribution approximately 0.35 L/kg; extensively distributed into tissues.
Protein BindingApproximately 96% bound to plasma proteins.
MetabolismExtensively metabolized in the liver via CYP2C19 and CYP3A4 isoenzymes.
Half-LifeApproximately 1-2 hours.
ExcretionApproximately 90% excreted in urine as metabolites, remainder in feces.
BioavailabilityApproximately 52% (oral).
Onset of ActionWithin 1 hour.
Peak Plasma Time2-4 hours.
Duration of ActionUp to 24 hours.

How It Works

Suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells.

Mechanism Steps

1Rabeprazole is a prodrug that accumulates in the acidic environment of parietal cell canaliculi.
2Protonation converts it to a sulfenamide active form.
3The active form binds covalently to cysteine residues of the H+/K+ ATPase enzyme.

๐Ÿ’ก How to Take acistal 20mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of acistal 20mg tablet

โœ… Common Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Constipation
  • Flatulence

๐Ÿšจ Serious Side Effects

  • Clostridium difficile-associated diarrhea
  • Fractures (hip, wrist, spine) with long-term use
  • Hypomagnesemia
  • Vitamin B12 deficiency
  • Acute interstitial nephritis

โš ๏ธ Rare Side Effects

  • Hepatic encephalopathy
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Agranulocytosis
  • Pancreatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Atazanavir Major Reduced absorption of atazanavir
Clopidogrel Moderate Reduced clopidogrel efficacy
Methotrexate Major Increased methotrexate toxicity
Digoxin Moderate Increased digoxin absorption
Ketoconazole Moderate Reduced ketoconazole absorption

๐Ÿšจ Major Interactions

  • Atazanavir
  • Rilpivirine
  • Nelfinavir
  • Methotrexate
  • Cilostazol

โšก Moderate Interactions

  • Clopidogrel
  • Digoxin
  • Ketoconazole
  • Itraconazole
  • Iron salts
  • Mycophenolate mofetil

โ„น๏ธ Minor Interactions

  • Sucralfate
  • Ampicillin
  • Tetracycline

๐Ÿฝ๏ธ Food Interactions

Food may delay absorption; best taken on an empty stomach.

๐Ÿท Alcohol Interaction

No direct interaction, but alcohol may exacerbate gastric irritation.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to rabeprazole or any component; concomitant use with rilpivirine.

๐Ÿ“Š Monitoring Parameters

Symptoms of acid-related disorders; liver function tests (if long-term); magnesium levels (prolonged use).

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution.

๐Ÿ’Š Overdose Management

Supportive care; no specific antidote; dialysis not effective.

โฐ Missed Dose

Take as soon as remembered unless near next dose; skip missed dose if close to next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for acistal 20mg tablet

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Alternative brands with exact same active ingredient (Rabeprazole (20mg)):

Medical Note: Always consult your doctor before switching medications.

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