Adipan D 20mg/40mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or cramping
- Chest pain, palpitations, or fainting
- Uncontrollable muscle spasms or tremors
- Swelling of face, lips, tongue, or throat
- Yellowing of skin or eyes
- Severe, persistent diarrhea with fever
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is acigrip dsr 20 mg/40 mg capsule used for?
This medicine is a combination of Domperidone and Pantoprazole used to treat acid reflux, gastritis, and related nausea. It works by reducing stomach acid and improving stomach emptying. It is usually taken once daily before breakfast.
- Generic Name: Domperidone + Pantoprazole
- Manufacturer: Alchemist Life Science Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 acigrip dsr 20 mg/40 mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और पैंटोप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, गैस्ट्र्रिटिस, और उससे जुड़ी मतली और उल्टी के इलाज के लिए किया जाता है। यह पेट में एसिड का उत्पादन कम करती है और पेट खाली होने की गति को बढ़ाती है, जिससे सीने में जलन, अपच, और पेट फूलने जैसे लक्षणों में राहत मिलती है। यह दवा आमतौर पर नाश्ते से 30-60 मिनट पहले खाली पेट ली जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, दस्त, मतली, पेट दर्द, मुंह सूखना और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें अनियमित दिल की धड़कन, मांसपेशियों में ऐंठन, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको कोई असामान्य लक्षण दिखे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे नाश्ते से 30-60 मिनट पहले खाली पेट लें। गोली को पानी के साथ निगलें, चबाएं नहीं। शराब का सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको हृदय, यकृत या गुर्दे की बीमारी है, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के दवा बंद न करें।
💊 acigrip dsr 20 mg/40 mg capsule Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Reduces stomach acid and helps relieve symptoms like heartburn, regurgitation, and difficulty swallowing.","evidence":"Well-established"},{"condition":"Peptic ulcer disease","description":"Helps heal ulcers in the stomach and duodenum by reducing acid production.","evidence":"Well-established"},{"condition":"Gastritis","description":"Reduces acid irritation of the stomach lining and relieves associated nausea and bloating.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps with symptoms like upper abdominal discomfort, early satiety, and post-meal fullness.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with acid-related disorders","description":"Domperidone component helps control nausea and vomiting by improving stomach emptying.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed to improve stomach emptying in people with diabetes, but evidence is limited.","evidence":"Limited"},{"condition":"Prevention of NSAID-induced ulcers","description":"May be used in patients on long-term NSAIDs who are at risk of ulcers, but not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD)
Also treats: Peptic ulcer disease, Gastritis, Functional dyspepsia, Nausea and vomiting
📋 Drug Information
| Generic Name(s) | Domperidone + Pantoprazole |
| Brand Name | Anleo-DSR Capsule |
| Manufacturer | Alchemist Life Science Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate or freeze. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Pantoprazole is a proton pump inhibitor that works by irreversibly binding to the hydrogen-potassium ATPase enzyme in the stomach's parietal cells, blocking the final step of acid secretion. This leads to a marked reduction in both basal and stimulated gastric acid production. Domperidone is a peripheral dopamine D2 receptor antagonist that acts on the chemoreceptor trigger zone and the gastrointestinal tract. By blocking dopamine receptors, it enhances gastric motility and accelerates gastric emptying, which helps reduce nausea, vomiting, and bloating. The combination provides both acid suppression and improved stomach emptying, addressing multiple aspects of acid-related disorders.
Mechanism Steps
💡 How to Take acigrip dsr 20 mg/40 mg capsule
Strength: Each tablet contains Domperidone 20 mg and Pantoprazole 40 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, preferably on an empty stomach 30 to 60 minutes before breakfast. However, the dose and frequency may vary depending on the specific condition being treated, its severity, and the patient's response. For some conditions, it may be taken twice daily. The maximum recommended dose should not be exceeded. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac effects and extrapyramidal symptoms. Use with caution and at the lowest effective dose. Regular monitoring is advised. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | No specific dose adjustment is typically required for mild to moderate renal impairment. However, in severe renal impairment, caution is advised, and the dose may need to be reduced. Consult your doctor for personalized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with moderate to severe hepatic impairment. In mild hepatic impairment, dose reduction may be considered. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of 20 mg domperidone and 40 mg pantoprazole. Do not exceed this dose unless specifically instructed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of acigrip dsr 20 mg/40 mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Ritonavir | Major | |
| Amiodarone | Major | |
| Warfarin | Moderate | |
| Clopidogrel | Moderate | |
| Atazanavir | Moderate | |
| Fluconazole | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor | |
| Vitamin B12 | Minor |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin
- Ritonavir, saquinavir
- Amiodarone, sotalol, quinidine, haloperidol
- Methotrexate
⚡ Moderate Interactions
- Warfarin
- Atazanavir, nelfinavir
- Clopidogrel
- Fluconazole
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase stomach acid production, which may counteract the effect of pantoprazole. It can also worsen side effects such as dizziness, drowsiness, and gastrointestinal irritation. Additionally, alcohol may increase the risk of liver problems when combined with pantoprazole.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone, pantoprazole, or any component of the formulation","Gastrointestinal obstruction, perforation, or bleeding","Prolactin-releasing pituitary tumor (prolactinoma)","Moderate to severe hepatic impairment","Concomitant use with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, ritonavir, or saquinavir","Known QT prolongation or congenital long QT syndrome","Concomitant use with QT-prolonging drugs such as amiodarone, sotalol, or quinidine"]
⚠️ Warnings & Precautions
["Use with caution in patients with cardiovascular disease or risk factors for QT prolongation.","Avoid use in patients with severe renal impairment unless benefits outweigh risks.","Long-term use may lead to vitamin B12 deficiency and hypomagnesemia; monitor levels.","May increase the risk of bone fractures with prolonged use.","Can mask symptoms of stomach cancer; rule out malignancy before starting treatment.","Use with caution in the elderly due to increased risk of side effects.","Do not use for longer than prescribed without medical supervision.","Inform your doctor if you have diabetes, as domperidone may affect blood sugar control.","Avoid driving or operating machinery if you experience dizziness or drowsiness."]
🤱 Lactation Safety
Domperidone is excreted in breast milk and may cause side effects in the nursing infant. Pantoprazole is also excreted in breast milk in small amounts. It is not recommended to use this medicine while breastfeeding unless specifically advised by your doctor. Consult your healthcare provider to discuss alternative options.
💊 Overdose Management
Overdose of this medicine may cause symptoms such as drowsiness, confusion, nausea, vomiting, and extrapyramidal reactions. In severe cases, cardiac arrhythmias may occur. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if the overdose is recent. Monitor vital signs and ECG closely. Contact a poison control center for guidance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water; do not crush or chew it. It is best taken on an empty stomach, at least 30 to 60 minutes before breakfast, because food can reduce the absorption of pantoprazole. However, if it upsets your stomach, you may take it with food after consulting your doctor. Do not take more than the recommended dose. Avoid alcohol while taking this medicine, as it can worsen stomach irritation and increase the risk of side effects. Inform your doctor if you have heart problems, liver disease, or kidney disease, as dose adjustments may be needed. Do not use this medicine for longer than prescribed without medical supervision. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before using this medicine. Keep this medicine out of the reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects such as cardiac arrhythmias, extrapyramidal symptoms, and falls due to dizziness. Use with caution and at the lowest effective dose. Regular monitoring of renal and hepatic function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. The safety of this combination during pregnancy is not well established. Your doctor may consider alternative treatments.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your doctor. It may affect gastric motility and acid secretion, which could impact post-operative recovery. Inform your surgeon about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may recommend precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid vigorous exercise immediately after meals as it may worsen reflux. Listen to your body and stop if you feel dizzy or experience palpitations.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue your daily activities, but take precautions if you feel unwell.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may advise tapering or stopping. Abrupt discontinuation can lead to rebound acid hypersecretion.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, hypomagnesemia, and an increased risk of bone fractures. It may also mask symptoms of stomach cancer. Regular monitoring of vitamin B12, magnesium, and bone health is advised. Periodic review with your doctor is necessary to assess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet changes, weight loss, and elevating the head of the bed can help manage acid reflux.
Evidence: Well-establishedH2 blockers like ranitidine or famotidine may be used as alternatives.
Evidence: Well-establishedOther prokinetics like metoclopramide may be used, but with different side effect profiles.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at the same local time as usual, but consult your doctor if you need specific adjustments. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling relief from nausea within 30-60 minutes, but full acid-suppressing effects may take 1-4 days of regular use.
A: It is best taken on an empty stomach 30-60 minutes before a meal. If it upsets your stomach, consult your doctor about taking it with food.
A: If you remember within 12 hours, take it as soon as possible. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Consult your doctor. The safety of this combination during pregnancy is not well established, and it should be used only if clearly needed.
A: Do not stop without consulting your doctor. Abrupt discontinuation may cause rebound acid hypersecretion.
🤔 Common Patient Concerns
🔄 Substitutes for acigrip dsr 20 mg/40 mg capsule
View AllAlternative brands with exact same active ingredient:
-
predom 20mg/40mg capsuleBestoChem Formulations India Ltd ₹36.06 51.3% CHEAPER
-
askapan-dm 20mg/40mg tabletAsklepios Remedies Pvt Ltd ₹45.00 39.2% CHEAPER
-
dunapan dsr 20mg/40mg tabletDunamed Pharmaceuticals (P) Ltd ₹50.00 32.5% CHEAPER
-
protopan-d tabletEast West Pharma ₹60.90 17.8% CHEAPER
-
pantozole dsr 20mg/40mg capsulePsycormedies ₹60.94 17.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken indefinitely without any risk.
Fact: Long-term use should be under medical supervision due to potential risks like vitamin B12 deficiency and bone fractures. - Myth: It is safe to take this medicine with any other medication.
Fact: It can interact with several drugs, including ketoconazole and warfarin, so always inform your doctor about all medicines you take. - Myth: This medicine provides instant relief from heartburn.
Fact: It may take a few days of regular use to achieve full effect, although some relief may be felt within hours.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Pantoprazole combination generics are available.
Brand Alternatives
- Dompan
- Pantop-D
- Domperidone + Pantoprazole brands