Atcid DSR 20 mg/40 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular heartbeat or palpitations
- Severe dizziness or fainting
- Uncontrolled muscle spasms or tremors
- Swelling of face, lips, or throat
- Yellowing of skin or eyes
- Blood in vomit or black stools
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is acigrip 20 mg/40 mg tablet used for?
This medicine is a combination of Domperidone 20 mg and Pantoprazole 40 mg used to treat acid reflux and poor stomach emptying. It works by reducing stomach acid and improving gut motility. It is usually taken once daily before breakfast.
- Generic Name: Domperidone (20mg) + Pantoprazole (40mg)
- Manufacturer: Alchemist Life Science Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 acigrip 20 mg/40 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन 20 मिलीग्राम और पैंटोप्राजोल 40 मिलीग्राम का संयोजन है। इसका उपयोग एसिड रिफ्लक्स, गैस्ट्रिक एसिडिटी, पेट में जलन, और पेट खाली होने में देरी जैसी समस्याओं के इलाज के लिए किया जाता है। यह पेट में एसिड का उत्पादन कम करती है और पेट की गति को बढ़ाती है, जिससे जी मिचलाना और उल्टी में राहत मिलती है। यह दवा डॉक्टर की सलाह पर ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के कुछ सामान्य दुष्प्रभाव हो सकते हैं जैसे सूखा मुँह, सिरदर्द, दस्त, पेट दर्द और जी मिचलाना। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी दिल की धड़कन अनियमित हो सकती है, स्तनों में दर्द या सूजन हो सकती है, या मांसपेशियों में ऐंठन हो सकती है। अगर आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे न चबाएं और न ही तोड़ें, पूरी गोली पानी के साथ निगलें। इसे सुबह नाश्ते से 30 से 60 मिनट पहले खाली पेट लें। एंटासिड के साथ इस दवा को लेने से बचें, कम से कम 2 घंटे का अंतर रखें। शराब न पिएं क्योंकि इससे पेट में जलन और नींद आने की समस्या बढ़ सकती है। अगर आपको किडनी या लीवर की बीमारी है तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के इस दवा को लंबे समय तक न लें।
💊 acigrip 20 mg/40 mg tablet Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD) with delayed gastric emptying","description":"Reduces acid reflux and speeds up stomach emptying, relieving heartburn, regurgitation, and bloating.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps with symptoms like upper abdominal pain, early fullness, and nausea by improving gastric motility and reducing acid.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with acid-related disorders","description":"Domperidone component helps control nausea and vomiting while pantoprazole treats the underlying acid problem.","evidence":"Moderate"},{"condition":"Gastritis with delayed gastric emptying","description":"Provides relief from inflammation-related symptoms and improves stomach emptying.","evidence":"Limited"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed off-label to improve gastric emptying in diabetic patients, but evidence is limited and risks must be weighed.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD) with delayed gastric emptying
Also treats: Functional dyspepsia, Gastritis, Nausea and vomiting associated with acid-related disorders
📋 Drug Information
| Generic Name(s) | Domperidone (20mg) + Pantoprazole (40mg) |
| Brand Name | acigrip 20 mg/40 mg tablet |
| Manufacturer | Alchemist Life Science Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Pantoprazole is a proton pump inhibitor that binds irreversibly to the hydrogen-potassium ATPase enzyme in the stomach lining, blocking the final step of acid secretion. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract, enhancing gastric motility and accelerating stomach emptying without crossing the blood-brain barrier significantly.
Mechanism Steps
💡 How to Take acigrip 20 mg/40 mg tablet
Strength: Tablet containing Domperidone 20 mg and Pantoprazole 40 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once daily on an empty stomach, at least 30 to 60 minutes before breakfast. However, the dose and frequency may vary depending on the condition being treated and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac effects and movement disorders. Use with caution and lower doses may be considered. Regular monitoring is advised. |
| Renal Impairment | No specific dose adjustment is generally required for mild to moderate renal impairment. In severe renal impairment, use with caution and monitor closely. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment is required in patients with mild to moderate liver impairment. This medicine is contraindicated in severe liver impairment. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (Domperidone 20 mg + Pantoprazole 40 mg) per day. Do not exceed this dose without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of acigrip 20 mg/40 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Warfarin | Moderate | |
| Clopidogrel | Moderate | |
| Methotrexate | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor | |
| Ritonavir | Major | |
| Apomorphine | Major | |
| Atazanavir | Moderate | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin
- Ritonavir, saquinavir
- Apomorphine
⚡ Moderate Interactions
- Warfarin
- Methotrexate
- Atazanavir, nelfinavir
- Clopidogrel
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase stomach acid production, counteracting the effect of pantoprazole, and can worsen domperidone-related side effects such as drowsiness and dizziness. It also increases the risk of gastrointestinal bleeding.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone, pantoprazole, or any component of the formulation","Gastrointestinal bleeding, mechanical obstruction, or perforation","Moderate to severe liver impairment","Known QT prolongation or family history of long QT syndrome","Concurrent use with QT-prolonging drugs or potent CYP3A4 inhibitors","Prolactin-releasing pituitary tumor (prolactinoma)","Breastfeeding"]
⚠️ Warnings & Precautions
["Use with caution in patients with heart disease or electrolyte imbalances.","Avoid in patients with risk factors for QT prolongation.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Long-term use may lead to vitamin B12 deficiency and hypomagnesemia.","May increase the risk of bone fractures with long-term use.","Use with caution in the elderly due to increased risk of side effects.","Do not use for more than 12 weeks without medical review."]
🤱 Lactation Safety
Domperidone passes into breast milk and may cause side effects in the infant. Pantoprazole may also pass into breast milk. This medicine is not recommended during breastfeeding unless clearly needed and advised by a doctor.
💊 Overdose Management
Overdose may cause severe drowsiness, irregular heartbeat, and extrapyramidal symptoms. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if taken recently. Monitor ECG and vital signs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with water. It is best taken on an empty stomach, at least 30 to 60 minutes before breakfast, to allow pantoprazole to work effectively. Avoid taking antacids within two hours of this medicine, as they can reduce its absorption. Do not drink alcohol while taking this medicine, as it can worsen stomach irritation and increase drowsiness. If you have kidney or liver problems, your doctor may need to adjust your dose or monitor you more closely. Do not use this medicine for longer than recommended without consulting your doctor. Keep out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects such as cardiac arrhythmias, movement disorders, and electrolyte imbalances. Use with caution and lower doses may be considered. Regular monitoring of heart, kidney, and liver function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your doctor. It may affect gastric motility and acid secretion, which could impact recovery. Inform your surgeon about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with certain medications used during dental work, and you may need to adjust the timing of your dose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid vigorous exercise immediately after taking this medicine, especially if you experience dizziness or drowsiness. Light to moderate exercise like walking is generally safe. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated. Inform your employer if you need any accommodations.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like irregular heartbeat, severe dizziness, or allergic reactions, stop immediately and seek medical help. Your doctor will advise you on when and how to stop based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, hypomagnesemia, and an increased risk of bone fractures. Domperidone can cause cardiac arrhythmias with prolonged use. Regular monitoring of vitamin B12, magnesium, and cardiac function is advised. Do not use for more than 12 weeks without a medical review.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Dietary changes, weight loss, and elevating the head of the bed can reduce reflux symptoms.
Evidence: Well-establishedH2 blockers like ranitidine or famotidine may be used as alternatives, but they are less effective than proton pump inhibitors.
Evidence: Well-establishedDomperidone alone may be used if acid suppression is not needed, but it does not treat acid reflux.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your doctor about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust the timing of your dose to maintain a 24-hour interval, but consult your doctor for specific advice. Keep it in your carry-on luggage to avoid loss or temperature extremes.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pantoprazole starts reducing acid within 1 hour, but maximum effect may take 2 to 4 days. Domperidone improves motility within 30 to 60 minutes. Symptom relief may be noticed within a few days.
A: It is best taken on an empty stomach, at least 30 to 60 minutes before breakfast. Food may reduce the absorption of domperidone and delay pantoprazole's effect.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It is generally safe for short-term use (up to 12 weeks) under medical supervision. Long-term use requires monitoring for side effects like vitamin B12 deficiency and cardiac risks.
A: Do not stop suddenly without consulting your doctor, as it may cause rebound acid hypersecretion. Your doctor will advise you on tapering or stopping.
🤔 Common Patient Concerns
🔄 Substitutes for acigrip 20 mg/40 mg tablet
View AllAlternative brands with exact same active ingredient:
-
predom 20mg/40mg capsuleBestoChem Formulations India Ltd ₹36.06 55.1% CHEAPER
-
askapan-dm 20mg/40mg tabletAsklepios Remedies Pvt Ltd ₹45.00 44% CHEAPER
-
dunapan dsr 20mg/40mg tabletDunamed Pharmaceuticals (P) Ltd ₹50.00 37.8% CHEAPER
-
protopan-d tabletEast West Pharma ₹60.90 24.2% CHEAPER
-
pantozole dsr 20mg/40mg capsulePsycormedies ₹60.94 24.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any stomach pain.
Fact: It is specifically for acid reflux and motility disorders. It is not a general painkiller. - Myth: It is safe to take indefinitely.
Fact: Long-term use should be monitored by a doctor due to potential side effects like vitamin B12 deficiency and cardiac risks. - Myth: You can stop it abruptly without consulting a doctor.
Fact: Stopping suddenly may cause rebound acid hypersecretion. Always consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Pantoprazole combination generics available
Brand Alternatives
- Not applicable