acidmute-dsr capsule - Uses, Price, Side Effects & Substitutes
What is acidmute-dsr capsule used for?
Amrizol-DSR Capsule (Domperidone + Esomeprazole) is used to treat GASTRO INTESTINAL. It contains Domperidone (30mg) + Esomeprazole (40mg), which Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and . Always consult your doctor before use. Take as prescribed.
- Generic Name: Domperidone + Esomeprazole
- Manufacturer: Meditouch Wellness
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ acidmute-dsr capsule Uses & Benefits
๐ Drug Information
| Generic Name(s) | Domperidone + Esomeprazole |
| Brand Name | Amrizol-DSR Capsule |
| Manufacturer | Meditouch Wellness |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Esomeprazole: Irreversibly inhibits H+/K+ ATPase in gastric parietal cells, reducing gastric acid secretion.
Mechanism Steps
๐ก How to Take acidmute-dsr capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of acidmute-dsr capsule
โ Common Side Effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Dry mouth
๐จ Serious Side Effects
- QT prolongation
- Torsades de pointes
- Gynecomastia
- Hyperprolactinemia
- Clostridium difficile infection
โ ๏ธ Rare Side Effects
- Jaundice
- Interstitial nephritis
- Anaphylaxis
- Extrapyramidal symptoms
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased risk of QT prolongation |
| Erythromycin | Major | Increased risk of cardiac arrhythmias |
| Clarithromycin | Major | Increased domperidone levels and QT prolongation risk |
| Ritonavir | Major | Increased domperidone levels |
| Amiodarone | Major | Increased risk of QT prolongation |
| Cimetidine | Moderate | Increased esomeprazole levels |
| Fluconazole | Moderate | Increased esomeprazole levels |
| Voriconazole | Moderate | Increased esomeprazole levels |
| Diltiazem | Moderate | Increased domperidone levels |
| Verapamil | Moderate | Increased domperidone levels |
| Sucralfate | Minor | Reduced absorption of esomeprazole |
| Antacids | Minor | Reduced absorption of esomeprazole |
| Digoxin | Minor | Possible increased digoxin levels |
๐จ Major Interactions
- Ketoconazole
- Erythromycin
- Clarithromycin
- Ritonavir
- Amiodarone
โก Moderate Interactions
- Cimetidine
- Fluconazole
- Voriconazole
- Diltiazem
- Verapamil
โน๏ธ Minor Interactions
- Sucralfate
- Antacids
- Digoxin
๐ฝ๏ธ Food Interactions
Food may delay absorption of domperidone; esomeprazole should be taken before meals for optimal effect.
๐ท Alcohol Interaction
Alcohol may increase gastric irritation and reduce drug efficacy.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, gastrointestinal hemorrhage, mechanical obstruction, perforation, prolactinoma, concurrent use with QT-prolonging drugs.
๐ Monitoring Parameters
ECG for QT interval, renal function, hepatic function, serum electrolytes.
๐คฑ Lactation Safety
Domperidone is excreted in breast milk; esomeprazole is likely excreted. Use with caution.
๐ Overdose Management
Supportive care, ECG monitoring, activated charcoal if recent ingestion.
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose. Do not double dose.